Післяопераційне знеболення у травматологічних хворих з ендопротезуванням кульшового суглоба

Дослідження проводилися у двох групах хворих (n = 82), оперованих під спинномозковою анестезією (СА) в стандартному виконанні. Дизайн передбачав створення двох рандомізованих груп пацієнтів: досліджувана група складає 42 хворих з ендопротезуванням кульшового суглоба, що підлягали оперативному втручанню, яким у комплекс терапії було включено препарат декскетопрофен за схемою: 1­ше введення в дозі 50 мг декскетопрофен внутрішньом’язово за 40 хв до оперативного втручання; 2­ге введення в тій же дозі (50 мг в/м) через 8 год від 1­го введення і 3­тє – в тій же дозі (50 мг в/м) через 8 год від 2­го введення. Добова доза лікарського засобу не перевищувала 150 мг/добу згідно з інструкцією до лікарського засобу. Група порівняння (група “Контроль”) складала 40 пацієнтів з аналогічними нозологіями та оперативними втручаннями з боку опорно­рухової системи. Пацієнти отримували стандартну терапію без планового застосування препарату декскетопрофен. Виявлено, що застосування декскетопрофену в плановому порядку у складі мультимодальної аналгезії в післяопераційному періоді у травматологічних хворих дозволяє досягти більш якісного знеболювання порівняно з аналгезією “за потребою” опіатами чи іншими НПЗЗ

Anisotropic Magnetoconductance in Quench-Condensed Ultrathin Beryllium Films

Near the superconductor-insulator (S-I) transition, quench-condensed ultrathin Be films show a large magnetoconductance which is highly anisotropic in the direction of the applied field. Film conductance can drop as much as seven orders of magnitude in a weak perpendicular field (< 1 T), but is insensitive to a parallel field in the same field range. We believe that this negative magnetoconductance is due to the field de-phasing of the superconducting pair wavefunction. This idea enables us to extract the finite superconducting phase coherence length in nearly superconducting films. Our data indicate that this local phase coherence persists even in highly insulating films in the vicinity of the S-I transition.Comment: 4 pages, 4 figure RevTex, Typos Correcte

An Expanded Multi-scale Monte Carlo Simulation Method for Personalized Radiobiological Effect Estimation in Radiotherapy: a feasibility study

A novel and versatile “bottom-up� approach is developed to estimate the radiobiological effect of clinic radiotherapy. The model consists of multi-scale Monte Carlo simulations from organ to cell levels. At cellular level, accumulated damages are computed using a spectrum-based accumulation algorithm and predefined cellular damage database. The damage repair mechanism is modeled by an expanded reaction-rate two-lesion kinetic model, which were calibrated through replicating a radiobiological experiment. Multi-scale modeling is then performed on a lung cancer patient under conventional fractionated irradiation. The cell killing effects of two representative voxels (isocenter and peripheral voxel of the tumor) are computed and compared. At microscopic level, the nucleus dose and damage yields vary among all nucleuses within the voxels. Slightly larger percentage of cDSB yield is observed for the peripheral voxel (55.0%) compared to the isocenter one (52.5%). For isocenter voxel, survival fraction increase monotonically at reduced oxygen environment. Under an extreme anoxic condition (0.001%), survival fraction is calculated to be 80% and the hypoxia reduction factor reaches a maximum value of 2.24. In conclusion, with biological-related variations, the proposed multi-scale approach is more versatile than the existing approaches for evaluating personalized radiobiological effects in radiotherapy

Наружные формы рекомбинантного интерферона альфа-2b — мазь и гель в комплексной терапии ОРВИ и гриппа у детей

The review article presents the results of numerous studies on the effectiveness and safety of the newly developed forms of the human recombinant interferon alpha- 2b drug, ointment and gel, intended for the treatment and prevention of acute respiratory viral infections and influenza in children. Еxternal forms of the drug retain immunomodulatory, antiviral and antiproliferative effects. The dosage form of the preparation of interferon alpha-2b VIFERON® in the form of a gel or ointment allows to achieve a prolonged action due to good absorption, especially the gel, which increases its effectiveness, and also has a moisturizing effect and rarely causes allergies. All of the above properties justify the inclusion of the drug interferon alpha-2b VIFERON® in the form of a gel or ointment in the complex treatment of influenza and acute respiratory viral infections in children.В обзорной статье представлены результаты многочисленных исследований по изучению эффективности и безопасности новых разработанных форм препарата интерферона альфа-2b человеческого рекомбинантного — мази и геля, предназначенных для терапии и профилактики ОРВИ и гриппа у детей. Наружные формы лекарственного средства сохраняют иммуномодулирующий, противовирусный и антипролиферативный эффекты. Лекарственная форма препарата интерферона альфа-2b ВИФЕРОН® в виде геля или мази позволяет достичь пролонгированного действия за счет хорошего всасывания, особенно геля, что повышает его эффективность, а также оказывает увлажняющее действие и редко вызывает аллергию. Все вышеперечисленные свойства обосновывают включение препарата интерферона альфа-2b ВИФЕРОН® в форме геля или мази в комплексную терапию гриппа и ОРВИ у детей

ГЕПАТИТ Е: НОВАЯ ПРОБЛЕМА ТРАНСПЛАНТОЛОГИИ?

Hepatitis E is enterically transmitted infection and is the cause of outbreaks and sporadic cases. Disease was originally registered only in the developing subtropical and tropical countries and has been connected with I or II genotypes of hepatitis E virus (HEV). Later sporadic hepatitis E has been registered in a number of the deve- loped countries of Western Europe, North America, South East Asia and Ocenia. These cases have been caused, as a rule, by III or IV genotypes of HEV. Until recently it was considered, that the disease is usually self-limited except pregnant women in which HEV infection is more severe, often leading to fulminant liver failure and death in a significant proportion of patients. The current review represents the analysis of publications of the last years reflecting the facts that HEV infection may develop in immunosuppressed patients, in particular in liver transplant recipients, who may then serve as long-term carriers of the virus with progression to cirrhosis. The information on the first attempts of antiviral therapy in these patients is presented. Гепатит Е относится к группе энтеральных гепатитов и может иметь характер как эпидемической, так и спорадической инфекции. Заболевание первоначально регистрировалось только в развивающихся суб- тропических и тропических странах и было связано с заражением I или II генотипами вируса. Позже спо- радический гепатит Е был зарегистрирован в ряде развитых стран Западной Европы, Северной Америки, Юго-Восточной Азии и Океании. Эти случаи были обусловлены инфицированием, как правило, III или IV генотипами вируса гепатита Е (HEV). До недавнего времени считалось, что течение болезни имеет об- ратимый характер и обычно завершается выздоровлением за исключением случаев заражения женщин на поздних сроках беременности, у которых была описана возможность развития фульминантного гепатита. Настоящий обзор посвящен анализу публикаций последних лет, отражающих течение HEV-инфекции у больных с иммунодефицитом, в частности у реципиентов трансплантатов солидных органов, для кото- рых совсем недавно была показана возможность хронизации болезни и трансформации ее в цирроз пече- ни. Представлена информация о первых попытках противовирусной терапии у этих больных.

Reactive Molecular Dynamics study on the first steps of DNA-damage by free hydroxyl radicals

We employ a large scale molecular simulation based on bond-order ReaxFF to simulate the chemical reaction and study the damage to a large fragment of DNA-molecule in the solution by ionizing radiation. We illustrate that the randomly distributed clusters of diatomic OH-radicals that are primary products of megavoltage ionizing radiation in water-based systems are the main source of hydrogen-abstraction as well as formation of carbonyl- and hydroxyl-groups in the sugar-moiety that create holes in the sugar-rings. These holes grow up slowly between DNA-bases and DNA-backbone and the damage collectively propagate to DNA single and double strand break.Comment: 6 pages and 8 figures. movies and simulations are available at: http://qmsimulator.wordpress.com

Cervical Screening within HIV Care: Findings from an HIV-Positive Cohort in Ukraine

HIV-positive women have an increased risk of invasive cervical cancer but cytologic screening is effective in reducing incidence. Little is known about cervical screening coverage or the prevalence of abnormal cytology among HIV-positive women in Ukraine, which has the most severe HIV epidemic in Europe

Quantum semantics of text perception

International audienceThe paper presents quantum model of subjective text perception based on binary cognitive distinctions corresponding to words of natural language. The result of perception is quantum cognitive state represented by vector in the qubit Hilbert space. Complex-valued structure of the quantum state space extends the standard vector-based approach to semantics, allowing to account for subjective dimension of human perception in which the result is constrained, but not fully predetermined by input information. In the case of two distinctions, the perception model generates a two-qubit state, entanglement of which quantifies semantic connection between the corresponding words. This twodistinction perception case is realized in the algorithm for detection and measurement of semantic connectivity between pairs of words. The algorithm is experimentally tested with positive results. The developed approach to cognitive modeling unifies neurophysiological, linguistic, and psychological descriptions in a mathematical and conceptual structure of quantum theory, extending horizons of machine intelligence

Еxternal forms of recombinant interferon alfa-2b - ointment and gel in the treatment of acute respiratory viral infections and influenza in children

The review article presents the results of numerous studies on the effectiveness and safety of the newly developed forms of the human recombinant interferon alpha- 2b drug, ointment and gel, intended for the treatment and prevention of acute respiratory viral infections and influenza in children. Еxternal forms of the drug retain immunomodulatory, antiviral and antiproliferative effects. The dosage form of the preparation of interferon alpha-2b VIFERON® in the form of a gel or ointment allows to achieve a prolonged action due to good absorption, especially the gel, which increases its effectiveness, and also has a moisturizing effect and rarely causes allergies. All of the above properties justify the inclusion of the drug interferon alpha-2b VIFERON® in the form of a gel or ointment in the complex treatment of influenza and acute respiratory viral infections in children