Experiment K-6-23. Effect of spaceflight on levels and function of immune cells

Two different immunology experiments were performed on samples received from rats flown on Cosmos 1887. In the first experiment, rat bone marrow cells were examined in Moscow for their response to colony stimulating factor-M. In the second experiment, rat spleen and bone marrow cells were stained in Moscow with a variety of antibodies directed against cell surface antigenic markers. These cells were preserved and shipped to the United States where they were subjected to analysis on a flow cytometer. The results of the studies indicate that bone marrow cells from flown rats showed a decreased response to colony stimulating factor than did bone marrow cells from control rats. There was a higher percentage of spleen cells from flown rats staining positively for pan-T-cell, suppressor-T-cell and innate interleukin-2 receptor antigens than from control animals. In addition, a higher percentage of cells that appeared to be part of the myelogenous population of bone marrow cells from flown rats stained positively for surface immunoglobulin than did equivalent cells from control rats

Information technologies in arts and music: the possibilities of their implementation in professional activity

При финансовой поддержке Российского гуманитарного научного фонда, проект № 07-06-14162

High-Q trenched aluminum coplanar resonators with an ultrasonic edge microcutting for superconducting quantum devices

Dielectric losses are one of the key factors limiting the coherence of superconducting qubits. The impact of materials and fabrication steps on dielectric losses can be evaluated using coplanar waveguide (CPW) microwave resonators. Here, we report on superconducting CPW microwave resonators with internal quality factors systematically exceeding 5x106 at high powers and 2x106 (with the best value of 4.4x106) at low power. Such performance is demonstrated for 100-nm-thick aluminum resonators with 7-10.5 um center trace on high-resistivity silicon substrates commonly used in quantum Josephson junction circuits. We investigate internal quality factors of the resonators with both dry and wet aluminum etching, as well as deep and isotropic reactive ion etching of silicon substrate. Josephson junction compatible CPW resonators fabrication process with both airbridges and silicon substrate etching is proposed. Finally, we demonstrate the effect of airbridges positions and extra process steps on the overall dielectric losses. The best quality fa ctors are obtained for the wet etched aluminum resonators and isotropically removed substrate with the proposed ultrasonic metal edge microcutting.Comment: 6 pages, 2 figure

Биотехнологический способ синтеза новых аналогов рибавирина.

Modern effective biotechnological method of the synthesis of new analogues of 1-β-D-ribifuranozyl-1,2,4- triazole-3-carboxamide (ribavirin) from 3-amino-1,2,4-triazole was developed. Gene-engineering enzymes purine- and, thymidine phosphorylasis were used for biothecnological method of the synthesis ribavirin analogs.Разработан эффективный биотехнологический способ получения аналогов рибавирина из 3-амино-1,2,4-триазола по реакции трансгликозилирования, осуществляемой с помощью рекомбинантных ферментных препаратов нуклеозидфосфорилаз

Microsporia morbidity in the Sverdlovsk region: epidemiological aspects, current features of the course

Purpose of our work is to study the current epidemiological aspects of the incidence of microsporia in the Sverdlovsk region of the adult and child population in the period from 2017 to 2021.Цель исследования – изучение современных эпидемиологических аспектов заболеваемости микроспорией в Свердловской области взрослого и детского населения в период с 2017 по 2021 гг

Giant and tunable excitonic optical anisotropy in single-crystal CsPbX3_3 halide perovskites

During the last years, giant optical anisotropy demonstrated its paramount importance for light manipulation which resulted in numerous applications ranging from subdiffraction light guiding to switchable nanolasers. In spite of recent advances in the field, achieving continuous tunability of optical anisotropy remains an outstanding challenge. Here, we present a solution to the problem through chemical alteration of the ratio of halogen atoms (X = Br or Cl) in single-crystal CsPbX$_3$ halide perovskites. It turns out that the anisotropy originates from an excitonic resonance in the perovskite, which spectral position and strength are determined by the halogens composition. As a result, we manage to continually modify the optical anisotropy by 0.14. We also discover that the halide perovskite can demonstrate optical anisotropy up to 0.6 in the visible range -- the largest value among non-van der Waals materials. Moreover, our results reveal that this anisotropy could be in-plane and out-of-plane, depending on perovskite shape -- rectangular and square. Hence, it can serve as an additional degree of freedom for anisotropy manipulation. As a practical demonstration, we created perovskite anisotropic nanowaveguides and show a significant impact of anisotropy on high-order guiding modes. These findings pave the way for halide perovskites as a next-generation platform for tunable anisotropic photonics.Comment: 18 pages, 3 figure