The prediction of electric energy consumption using an artificial neural network

This paper presents the results of the studies on forecasting the electrical loads for a megapolis district with the use of artificial neural networks (ANN) as one of the most accomplished and promising solutions to this challenge. A theoretical approach to the issue is combined with the results of experimental studies using real schedules. © 2014 WIT Press.International Journal of Safety and Security Engineering;International Journal of Sustainable Development and Planning;WIT Transactions on Ecology and the Environmen

Optimal placement units of distributed generation

In this paper a new approach to solve the problem of optimal placement of distributed generation sources is proposed. The method is aimed at improving the reliability of electricity supply. The mathematical model of the optimal placement of distributed generation sources (DG) based on improving the reliability of power supply as the optimization algorithm used a genetic algorithm. The results of experimental calculations and comparative analysis of the algorithm is shown. © 2014 WIT Press.International Journal of Safety and Security Engineering;International Journal of Sustainable Development and Planning;WIT Transactions on Ecology and the Environmen

Multilevel Parallelization: Grid Methods for Solving Direct and Inverse Problems

In this paper we present grid methods which we have developed for solving direct and inverse problems, and their realization with different levels of optimization. We have focused on solving systems of hyperbolic equations using finite difference and finite volume numerical methods on multicore architectures. Several levels of parallelism have been applied: geometric decomposition of the calculative domain, workload distribution over threads within OpenMP directives, and vectorization. The run-time efficiency of these methods has been investigated. These developments have been tested using the astrophysics code AstroPhi on a hybrid cluster Polytechnic RSC PetaStream (consisting of Intel Xeon Phi accelerators) and a geophysics (seismic wave) code on an Intel Core i7-3930K multicore processor. We present the results of the calculations and study MPI run-time energy efficiency

Використання аліфатичних альдегідів у синтезі нових 1H-2,1-бензотіазин-4-он 2,2-діоксидів, конденсованих з пірановим ядром за допомогою доміно-взаємодій. Антимікробна активність синтезованих сполук

Domino-type Knoevenagel-Michael-hetero-Thorpe-Ziegler and Knoevenagel-hetero-Diels-Alder interactions using 1-ethyl-1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide and aliphatic aldehydes as initial compounds have been studied. These reactions have led to 2-amino-3-cyano-4H-pyran and 2H-3,4-dihydropyran derivatives, respectively. It has been shown that the three-component one-pot interaction of 1-ethyl-1H-2,1-benzothiazin-4(3H)one 2,2-dioxide with saturated aliphatic aldehydes and malononitrile proceeds under rather mild conditions and results in formation of 2-amino-6-ethyl-4-alkyl-4,6-dihydropyrano[3,2-c][2,1]benzothiazin-3-carbonitrile 5,5-dioxides with moderate and high yields. At the same time, the yields of target products decrease with the increase of the length of the aliphatic aldehyde carbon chain. In this regard, the use of citronellal allowed us to obtain the product of the three-component interaction with a low yield. To date, there is no information in the literature about the possible application of aliphatic dialdehydes in such three-component interactions. It has been found that the use of glutaric aldehyde results in the synthesis of a new class of bis-derivatives of 2-amino-4H-pyran, in which two fragments are linked by the polymethylene bridge. The use of α,β-unsaturated aldehydes in the three-component interaction with 1-ethyl-1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide and malononitrile was accompanied by decrease in the process efficiency compared to saturated aliphatic aldehydes. The target fused 2-amino-3-cyano-4H-pyran was obtained only when α-methylcinnamic aldehyde was used in the reaction. A two-component interaction of 1-ethyl-1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide with citronellal has been also studied. It has been shown that this reaction is stereospecific. It proceeds through domino Knoevenagel-heteroDiels-Alder sequence resulting in a new heterocyclic system – 2,2a,3,4,5,6,6a,8-octahydroisochromeno[4,3-c] [2,1]benzothiazine 7,7-dioxide. The study of the antimicrobial activity of the compounds synthesized has allowed finding compounds with a moderate activity against P. aeruginosa і C. albicans.Изучены домино-взаимодействия Кневенагеля-Михаэля-гетеро-Торпа-Циглера и Кневенагеля-гетеро-Дильса-Альдера с участием 1-этил-2,1-бензотиазин-4(3Н)-он 2,2-диоксида и алифатических альдегидов, приводящих соответственно к образованию производных 2-амино-3-циано-4Н-пирана и 2Н-3,4-дигидропирана. Показано, что трехкомпонентное одностадийное взаимодействие 1-этил-2,1-бензотиазин-4(3Н)-он 2,2-диоксида с насыщенными алифатическими альдегидами и малонодинитрилом протекает в очень мягких условиях и приводит к образованию 2-амино-6-этил-4-алкил-4,6-дигидропирано[3,2-c][2,1]бензотиазин-3-карбонитрил 5,5-диоксидов с высокими и умеренными выходами. В то же время увеличение длины углеродной цепи алифатических альдегидов приводит к уменьшению выхода целевых продуктов. Так, при использовании цитронеллаля продукт трехкомпонентного взаимодействия удалось получить только с невысоким выходом. Алифатические диальдегиды не были ранее использованы в данных взаимодействиях; показано, что применение глутарового альдегида приводит к новому классу бис-производных 2-амино-4Н-пирана, в котором фрагменты соединены полиметиленовым мостиком. Использование α,β-ненасыщенных альдегидов в трехкомпонентном взаимодействии с 1-этил-2,1-бензотиазин-4(3Н)-он 2,2-диоксидом и малонодинитрилом сопровождалось уменьшением эффективности процесса по сравнению с насыщенными алифатическими альдегидами. Целевой продукт взаимодействия конденсированный 2-амино-3-циано-4Н-пиран был получен только в случае применения α-метилкоричного альдегида. Изучено взаимодействие между 1-этил-2,1-бензотиазин-4(3Н)-он 2,2-диоксидом и цитронеллалем; показано, что данная реакция протекает исключительно как стерео-специфичное домино-взаимодействие Кневенагеля-гетеро-Дильса-Альдера и приводит к образованию новой гетероциклической системы – 2,2a,3,4,5,6,6a,8-октагидроизохромено[4,3-c][2,1]бензотиазин 7,7-диоксида. Изучение антимикробной активности синтезированных соединений позволило обнаружить производные, проявляющие умеренную активность против P. aeruginosa и C. albicansВивчені доміно-взаємодії Кньовенагеля-Міхаеля-гетеро-Торпа-Ціглера та Кньовенагеля-гетеро-Дільса-Альдера за участю 1-етил-1Н-2,1-бензотіазин-4(3Н)-ону 2,2-діоксиду та аліфатичних альдегідів, що приводять до утворення відповідно похідних 2-аміно-3-ціано-4Н-пірану та 2Н-3,4-дигідропірану. Показано, що трикомпонентна одностадійна взаємодія 1-етил-1Н-2,1-бензотіазин-4(3Н)-ону 2,2-діоксиду з насиченими аліфатичними альдегідами і малонодинітрилом перебігає у дуже м’яких умовах і приводить до утворення 2-аміно-6-етил-4-алкіл-4,6-дигідропірано[3,2 c][2,1]бензотіазин-3-карбонітрил 5,5-діоксидів з високими та помірними виходами. У той же час збільшення довжини вуглецевого ланцюга аліфатичного альдегіду приводить до зменшення виходу цільових продуктів. Так, при використанні цитронелалю продукт трикомпонентної взаємодії вдалося одержати тільки з невисоким виходом. Аліфатичні діальдегіди не були раніше використані у даних взаємодіях; показано, що використання глутарового альдегіду дозволяє отримати новий клас біс-похідних 2-аміно-4Н-пірану, в якому фрагменти з’єднані поліметиленовим містком. Використання α,β-ненасичених альдегідів у трикомпонентній взаємодії з 1-етил-1Н-2,1-бензотіазин-4(3Н)-ону 2,2-діоксидом і малонодинітрилом супроводжувалося зменшенням ефективності процесу в порівнянні з насиченими аліфатичними альдегідами. Цільовий продукт взаємодії конденсований 2-аміно-3-ціано-4Н-піран був отриманий тільки у випадку застосування α-метилкоричного альдегіду. Вивчена взаємодія між 1-етил-1Н-2,1-бензотіазин-4(3Н)-ону 2,2-діоксидом і цитронелалем; показано, що така реакція перебігає винятково як стереоспецифічна доміно-взаємодія Кньовенагеля-гетеро-Дільса-Альдера і приводить до утворення нової гетероциклічної системи – 2,2a,3,4,5,6,6a,8-октагідроізохромено[4,3-c][2,1]бензотіазин 7,7-діоксиду. Вивчення антимікробної активності синтезованих сполук дозволило виявити похідні, що проявляють помірну активність проти P. aeruginosa і C. albicans

Consistent alpha-cluster description of the 12C (0^+_2) resonance

The near-threshold 12C (0^+_2) resonance provides unique possibility for fast helium burning in stars, as predicted by Hoyle to explain the observed abundance of elements in the Universe. Properties of this resonance are calculated within the framework of the alpha-cluster model whose two-body and three-body effective potentials are tuned to describe the alpha - alpha scattering data, the energies of the 0^+_1 and 0^+_2 states, and the 0^+_1-state root-mean-square radius. The extremely small width of the 0^+_2 state, the 0_2^+ to 0_1^+ monopole transition matrix element, and transition radius are found in remarkable agreement with the experimental data. The 0^+_2-state structure is described as a system of three alpha-particles oscillating between the ground-state-like configuration and the elongated chain configuration whose probability exceeds 0.9

Oxidative protein modification of the temporal bone tissue in chronic otitis media

Aim. To study the role of oxidative protein modification of bone tissue proteins in the formation of destruction of temporal bone structures in chronic otitis media. Methods. The study included 139 patients aged 16-75 years with a verified diagnosis of chronic otitis media, who are candidates for surgical treatment. Depending on the method of surgical treatment, patients are divided into four groups (by nosology and complications and reoperations): patients with tubotympanic otitis media and epitympanic antral otitis, without complications and with local or intracranial complications, after reconstructive sanitizing ear surgery. The state of the processes of oxidative modification of proteins was evaluated in the bone tissue of the middle ear cavities, obtained intraoperatively, by the content of carbonyl products with the use of spectrophotometry. The data were processed by descriptive statistics and were presented in the form of a median and a range between quartiles with an estimate of the reliability of the intergroup differences by the Mann-Whitney U-criterion. Results. A comparison of the indicators characterizing the oxidative modification of bone tissue proteins of the temporal bone in patients with complicated and recurrent forms of chronic otitis media demonstrates a greater degree of free radical destruction of proteins, primarily markers of early stages of protein damage and an increase of aldehyde products, both at the basal level and in response to induction in a complicated course of the disease. Conclusion. The obtained data allow drawing a conclusion about a high level of oxidative stress in bone tissue in destructive forms of chronic otitis media accompanied by relapses and complications, and about the perspectives of antioxidant pre-operative use taking into account the features of oxidative stress in bone tissue in patients with chronic otitis media

The peculiarities of oral cavity and its subjective estimation of women with PCOS

The article presents the results of research the aim of which was describing of the peculiarities of oral cavity and its subjective estimation by women with PCOS. On the sample of 50 subjects with PCOS (diagnosed in accordance with Rotterdam consensus] we used the following: oral cavity examination: Gingeval Index, CPITN calculations and WHO questionnaires on oral cavity health for adults. As a result of oral cavity examination we have not found any serious pathology, but 20 % of patients demonstrated gingival bleeding. At the same time, the self-estimation of oral cavity conditions by women with PCOS was "satisfactory" in 34 %, "good" - in 44 % and "excellent" in 22 %. The indices recommended by WHO for estimation of oral cavity conditions (CPITN and GI] were generally within the normal ranges and characterized oral cavity status of the women with PCOS as good. However, in PCOS patients with high degree of gum bleeding the CPITN and GI indexes were increased, and these patients reported that they visited а dentist more frequently. Changes in the condition of the oral cavity in PCOS were not associated with any specific behavior of women in the care of teeth and oral cavity. The authors suggest that additional investigation of microbiome should be done for further more comprehensive analysis of oral cavit

Clinical and diagnostic evaluation of the effectiveness of treatment of optic neuropathy in patients with edematous endocrine ophthalmopathy

The aim: to conduct a clinical and diagnostic evaluation of the effectiveness of the administration of a complex of drugs in the region of hemolymphocirculation in optical neuropathy in patients with edematous form of endocrine ophthalmopathy.Materials and methods. The results of diagnosis and treatment of 31 patients (61 eyes) with optical neuropathy on the background of edematous exophthalmos in endocrine ophthalmopathy were analyzed. To identify hidden forms of optical neuropathy, such studies were prescribed as computer microperimetry on a confocal infrared ophthalmoscope, a complex of electroretinographic studies: registration of maximum ERG, oscillatory potentials. Latent forms of optical neuropathy were detected in 22 cases. In 9 cases, there were obvious forms of optical neuropathy. All patients underwent a 10-day course of intensive complex treatment, consisting of injections into the region of hemolymphocirculation (projection of the pterygoid fossa) No. 6–8 (No. 3–4 on each side) with an interval of 24 hours of a drug mixture, the formulation of which included Lidocaine 20 mg, Dexazone 4 mg, Hemase 3000 UNITS, Dalargin 1 mg.Results. In all patients, there was a pronounced positive dynamics in the form of a significant (from 0.6 to 1.0) increase in visual acuity, a decrease in exophthalmos from (2.0 to 3.0 mm), an increase in color and contrast sensitivity.Conclusions. Due to the violation of venous and lymphatic outflow due to thickening of extraocular muscles and retrobulbar fiber, injections into the hemolymphocirculation region (projection of the pterygoid fossa) of drugs with a wide range of decongestant and metabolic effects are justified, effective and safe

Giant Coulomb broadening and Raman lasing on ionic transitions

CW generation of anti-Stokes Raman laser on a number of blue-green argon-ion lines (4p-4s, 4p-3d) has been demonstrated with optical pumping from metastable levels 3d'^2G, 3d^4F. It is found, that the population transfer rate is increased by a factor of 3-5 (and hence, the output power of such Raman laser) owing to Coulomb diffusion in the velocity space. Measured are the excitation and relaxation rates for the metastable level. The Bennett hole on the metastable level has been recorded using the probe field technique. It has been shown that the Coulomb diffusion changes shape of the contour to exponential cusp profile while its width becomes 100 times the Lorentzian one and reaches values close to the Doppler width. Such a giant broadening is also confirmed by the shape of the absorption saturation curve.Comment: RevTex 18 pages, 5 figure

POLYMORPHISMS OF EXTRACELLULAR CONNECTIVE TISSUE REMODELING PROTEINASES AND <i>MMP2, MMP3, MMP9</i> GENES, AND NEOANGIGENESIS <i>VEGF</i> GENE IN RETINAL MICROANGIOPATHY IN THE PATIENTS WITH TYPE 2 DIABETES MELLITUS

The aim of our study was to perform an association analysis between MMP2, MMP3, MMP9, VEGF gene polymorphisms and development of non-proliferative diabetic retinopathy (DR) in the type 2 diabetic patients (DM).201 DM patients: 90 cases of DR and 111 subjects without DR features were included into the study. Polymorphic variants of MMP2 (rs2438650), MMP3 (rs3025058), MMP9 (rs3918242), and VEGF (rs699947 and rs3025039) genes were assayed. The genetic typing was carried out by restriction fragment length polymorphism and TaqMan methods.The analysis of complex genotypes at the five polymorphic positions has revealed some significant findings in positive and negatively incorporated complexes. Increased frequencies of MMP2-1306 CC genotype in the group of patients with “early” development of complication, and more frequent combination of high-level HbA1c with MMP2-1306CC and MMP9-1562CT genotypes were shown in DR patients. Computerassisted modelling with visual reconstruction of network interactions between the genotypes involved into the destruction events and angiogenesis, as well as altered HbA1с levels (an integral parameter of glycemia), has revealed some differences in structural and functional organization of gene-gene and gene- protein interactions between the groups of patients with DR versus those without this disorder. Сonclusion. A design of interactome biological networks based on transcription regulation and metabolic pathways, as well as their topological analysis allows to build and study interactions of genes and proteins, with reference to pathogenetic studies of DM2 complications aiming for development of approaches to personalized prevention and therapy in future times