The North Italian innovative project for common psychiatric disorders: Evaluating the output of a treatment model of an outpatient clinic for anxiety and depression

Depressive disorders were considered the first causes of disability worldwide as early as 2018. The outpatient clinic for anxiety and depression at the University Hospital of Varese represents a service that fully responds to the growing number of requests. Approximately 1,350 medical records have been opened from 2010 to December 2021. The most frequent presenting diagnoses included anxiety disorders (36.8%), severe stress and maladaptation syndromes (35.5%), and depressive episodes (18%). The outpatient clinic has proved to be a model with great impact on users offering a range of diagnostic and therapeutic offers responding to the requests of the community

Energetics and Possible Formation and Decay Mechanisms of Vortices in Helium Nanodroplets

The energy and angular momentum of both straight and curved vortex states of a helium nanodroplet are examined as a function of droplet size. For droplets in the size range of many experiments, it is found that during the pickup of heavy solutes, a significant fraction of events deposit sufficient energy and angular momentum to form a straight vortex line. Curved vortex lines exist down to nearly zero angular momentum and energy, and thus could in principle form in almost any collision. Further, the coalescence of smaller droplets during the cooling by expansion could also deposit sufficient angular momentum to form vortex lines. Despite their high energy, most vortices are predicted to be stable at the final temperature (0.38 K) of helium nanodroplets due to lack of decay channels that conserve both energy and angular momentum.Comment: 10 pages, 8 figures, RevTex 4, submitted to Phys. Rev.

Forming and preserving aragonite in shear zones: First report of blueschist facies metamorphism in the Jabal Akhdar Dome, Oman Mountains

We report the first occurrence of high-pressure metamorphic aragonite in Precambrian carbonates of the Jabal Akhdar Dome in the Oman Mountains (northern Oman). We propose a model for both its formation at blueschist facies conditions and its subsequent preservation to the surface within the tectonic framework of the Late Cretaceous obduction of the Semail Ophiolite. Aragonite formed at temperature ∼350 °C and pressure ≥0.9 GPa and is preserved within mylonitic shear zones and in stretched-fiber dilational veins where the necessary conditions for its formation and preservation, such as plastic strain accommodation, fluid-enhanced mineralogical reactions, and an anisotropic permeability structure, were preferentially met with respect to the surrounding rock. High-strain structural domains are ideal sites to look for and study prograde and retrograde high-pressure metamorphic histories in deeply subducted and exhumed terrains

A new FSA approach for in situ γ\gamma-ray spectroscopy

An increasing demand of environmental radioactivity monitoring comes both from the scientific community and from the society. This requires accurate, reliable and fast response preferably from portable radiation detectors. Thanks to recent improvements in the technology, $\gamma$-spectroscopy with sodium iodide scintillators has been proved to be an excellent tool for in-situ measurements for the identification and quantitative determination of $\gamma$-ray emitting radioisotopes, reducing time and costs. Both for geological and civil purposes not only $^{40}$K, $^{238}$U, and $^{232}$Th have to be measured, but there is also a growing interest to determine the abundances of anthropic elements, like $^{137}$Cs and $^{131}$I, which are used to monitor the effect of nuclear accidents or other human activities. The Full Spectrum Analysis (FSA) approach has been chosen to analyze the $\gamma$-spectra. The Non Negative Least Square (NNLS) and the energy calibration adjustment have been implemented in this method for the first time in order to correct the intrinsic problem related with the $\chi ^2$ minimization which could lead to artifacts and non physical results in the analysis. A new calibration procedure has been developed for the FSA method by using in situ $\gamma$-spectra instead of calibration pad spectra. Finally, the new method has been validated by acquiring $\gamma$-spectra with a 10.16 cm x 10.16 cm sodium iodide detector in 80 different sites in the Ombrone basin, in Tuscany. The results from the FSA method have been compared with the laboratory measurements by using HPGe detectors on soil samples collected in the different sites, showing a satisfactory agreement between them. In particular, the $^{137}$Cs isotopes has been implemented in the analysis since it has been found not negligible during the in-situ measurements.Comment: accepted by Science of Total Environment: 8 pages, 10 figures, 3 table

Ordering of binary colloidal crystals by random potentials

Structural defects are ubiquitous in condensed matter, and not always a nuisance. For example, they underlie phenomena such as Anderson localization and hyperuniformity, and they are now being exploited to engineer novel materials. Here, we show experimentally that the density of structural defects in a 2D binary colloidal crystal can be engineered with a random potential. We generate the random potential using an optical speckle pattern, whose induced forces act strongly on one species of particles (strong particles) and weakly on the other (weak particles). Thus, the strong particles are more attracted to the randomly distributed local minima of the optical potential, leaving a trail of defects in the crystalline structure of the colloidal crystal. While, as expected, the crystalline ordering initially decreases with an increasing fraction of strong particles, the crystalline order is surprisingly recovered for sufficiently large fractions. We confirm our experimental results with particle-based simulations, which permit us to elucidate how this non-monotonic behavior results from the competition between the particle-potential and particle-particle interactions

Defining the Substrate Spectrum of the TIM22 Complex Identifies Pyruvate Carrier Subunits as Unconventional Cargos

Mitochondria carrier proteins, which possess six transmembrane spans (TM), are transported by the TIM22 complex. By using a quantitative proteomic approach, Gomkale and Cruz-Zaragoza et al. reveal subunits of the mitochondrial pyruvate carrier (MPC) that possess two or three TMs as unexpected substrates of the carrier pathway

Studio della quota di volo mediante GNSS, altimetro radar e barometro per rilievi di spettroscopia gamma da velivolo

Lo studio della distribuzione dei radionuclidi terrestri (238U, 232Th e 40K) realizzato mediante tecniche di spettroscopia gamma da velivolo è influenzato dalla quota a cui il rivelatore si trova rispetto al suolo. Un'incertezza del 10% a 100 m di altezza origina un errore nella stima del segnale gamma del 208Tl, appartenente alla catena di decadimenti del 232Th, dell’ordine del 7%. L'impiego di una nuova classe di spettrometri montati a bordo di UAV (Unmanned Aerial Vehicle) per raffinate misure in contesti ostili o remoti rende necessaria un'accurata stima in real time della quota di volo. Il Radgyro è un velivolo dedicato a survey multiparametrici, capace di trasportare strumentazione pari ad un payload massimo di 120 kg, tra cui quattro spettrometri gamma NaI(Tl). Una stazione inerziale con ricevitore integrato GNSS (Global Navigation Satellite System) restituisce l'assetto del velivolo con una frequenza massima di 400 Hz. Il velivolo è dotato di un network di tre ricevitori GNSS posizionati alle estremità della carena del velivolo. Un altimetro radar a 24 GHz rileva la quota con una frequenza di 60 Hz. La misura di pressione e temperatura consente di ricavare la quota barometrica a 2 Hz. Con l'obiettivo di studiare le incertezze associate alle misure della quota di volo acquisite dagli altimetri in relazione ai dati GNSS, sono stati realizzati tre voli sul mare in un range di altezze comprese tra 31 m e 249 m, per un totale di 4702 secondi di volo effettivo. Al termine dello studio è possibile concludere che l'errore complessivo delle abbondanze di K, U e Th aumenta di 7.7%, 0.5% e 2.7% rispettivamente, a causa delle incertezze della quota di volo