A convergence on Boolean algebras generalizing the convergence on the Aleksandrov cube

We compare the forcing related properties of a complete Boolean algebra B with the properties of the convergences $\lambda_s$ (the algebraic convergence) and $\lambda_{ls}$ on B generalizing the convergence on the Cantor and Aleksandrov cube respectively. In particular we show that $\lambda_{ls}$ is a topological convergence iff forcing by B does not produce new reals and that $\lambda_{ls}$ is weakly topological if B satisfies condition $(\hbar)$ (implied by the ${\mathfrak t}$-cc). On the other hand, if $\lambda_{ls}$ is a weakly topological convergence, then B is a $2^{\mathfrak h}$-cc algebra or in some generic extension the distributivity number of the ground model is greater than or equal to the tower number of the extension. So, the statement "The convergence $\lambda_{ls}$ on the collapsing algebra B=\ro ((\omega_2)^{<\omega}) is weakly topological" is independent of ZFC

Measurable Consequences of the Local Breakdown of the Concept of Temperature

Local temperature defined by a local canonical state of the respective subsystem, does not always exist in quantum many body systems. Here, we give some examples of how this breakdown of the temperature concept on small length scales might be observed in experiments: Measurements of magnetic properties of an anti-ferromagnetic spin-1 chain. We show that those magnetic properties are in fact strictly local. As a consequence their measurement reveals whether the local (reduced) state can be thermal. If it is, a temperature may be associated to the measurement results, while this would lead to inconsistencies otherwise.Comment: some comments added, results remain unchange

Early Antibiotic Exposure Is Not Detrimental to Therapeutic Effect from Immunotherapy in Hepatocellular Carcinoma

BACKGROUND AND RATIONALE: Immune checkpoint inhibitor (ICI) therapy is an expanding therapeutic option for hepatocellular carcinoma (HCC). Antibiotics (ATB) taken prior to or early during ICI therapy can impact immunotherapy efficacy across indications; however, the effect of ATB is undefined in HCC. METHODS: In a large international cohort of 450 ICI recipients from Europe, North America, and Asia, we categorized patients according to timing of ATB focusing on exposure within −30 to +30 days from ICI (early immunotherapy period [EIOP]). EIOP was evaluated in association with overall survival (OS), progression-free survival (PFS), and best radiologic response using RECIST 1.1 criteria. RESULTS: Our study comprised mostly cirrhotic (329, 73.3%) males (355, 79.1%) with a Child-Turcotte Pugh class of A (332, 73.9%), receiving ICI after 1 therapy line (251, 55.9%) for HCC of Barcelona clinic liver cancer stage C (325, 72.4%). EIOP (n = 170, 37.9%) was independent of baseline clinicopathologic features of HCC and correlated with longer PFS (6.1 vs. 3.7 months, log-rank p = 0.0135). EIOP+ patients had similar OS, overall response, and disease control rates (DCRs) compared to EIOP. The effect of EIOP persisted in landmark time analyses and in multivariable models, confirming the independent predictive role of EIOP in influencing PFS following adjustment for covariates reflective of tumor burden, liver function, and ICI regimen administered. In patients receiving programmed cell death-1 receptor/ligand inhibitors monotherapy, EIOP was also associated with higher DCRs (61.4% vs. 50.9%, p = 0.0494). CONCLUSIONS: Unlike other oncological indications, ATB in the 30 days before or after ICI initiation is associated with improved benefit from immunotherapy, independent of disease and treatment-related features. Evaluation of the immune microbiologic determinants of response to ICI in HCC warrants further investigation

Estas son algunas de las habilidades blandas demandadas en Colombia

Este producto forma parte de una serie de infografías de divulgación científica que buscan reseñar algunas de las investigaciones más importantes en las que ha tenido participación la Universidad EAFIT, publicadas en las revistas especializadas más prestigiosas del mund

Effect of soil liming on European beech (Fagus sylvatica L.) and sycamore maple (Acer pseudoplatanus L.) plantations

Support of European beech (Fagus sylvatica L.) and sycamore maple (Acer pseudoplatanus L.) plantations by amelioration has been tested in air-polluted sites in the mountains since 1993. The research locality is a site with humic podzol soils at an altitude of 960 m a.s.l. Dolomitic limestone (1 kg per tree) was mixed with soil used for planting tree seedlings. According to the results of a 15-year investigation (1993– 2008), liming had a positive effect on beech tree growth, while the positive effect of liming on tree growth was temporary in the case of sycamores. Ca content was higher in the limed beech plantations throughout the observation period. Soil analyses (sampled in 2002) showed that the application of dolomitic limestone influenced soil conditions markedly in terms of increased pH. The pH values measured in H2O increased from 4.9 to 6.2 for beeches and from 4.3 to 6.1 for sycamores