Birth size and breast cancer risk: Re-analysis of individual participant data from 32 studied

Background Birth size, perhaps a proxy for prenatal environment, might be a correlate of subsequent breast cancer risk, but findings from epidemiological studies have been inconsistent. We re-analysed individual participant data from published and unpublished studies to obtain more precise estimates of the magnitude and shape of the birth size–breast cancer association. Methods and Findings Studies were identified through computer-assisted and manual searches, and personal communication with investigators. Individual participant data from 32 studies, comprising 22,058 breast cancer cases, were obtained. Random effect models were used, if appropriate, to combine study-specific estimates of effect. Birth weight was positively associated with breast cancer risk in studies based on birth records (pooled relative risk [RR] per one standard deviation [SD] [= 0.5 kg] increment in birth weight: 1.06; 95% confidence interval [CI] 1.02–1.09) and parental recall when the participants were children (1.02; 95% CI 0.99–1.05), but not in those based on adult self-reports, or maternal recall during the woman's adulthood (0.98; 95% CI 0.95–1.01) (p for heterogeneity between data sources = 0.003). Relative to women who weighed 3.000–3.499 kg, the risk was 0.96 (CI 0.80–1.16) in those who weighed < 2.500 kg, and 1.12 (95% CI 1.00–1.25) in those who weighed ≥ 4.000 kg (p for linear trend = 0.001) in birth record data. Birth length and head circumference from birth records were also positively associated with breast cancer risk (pooled RR per one SD increment: 1.06 [95% CI 1.03–1.10] and 1.09 [95% CI 1.03–1.15], respectively). Simultaneous adjustment for these three birth size variables showed that length was the strongest independent predictor of risk. The birth size effects did not appear to be confounded or mediated by established breast cancer risk factors and were not modified by age or menopausal status. The cumulative incidence of breast cancer per 100 women by age 80 y in the study populations was estimated to be 10.0, 10.0, 10.4, and 11.5 in those who were, respectively, in the bottom, second, third, and top fourths of the birth length distribution. Conclusions This pooled analysis of individual participant data is consistent with birth size, and in particular birth length, being an independent correlate of breast cancer risk in adulthood

Interplay between disorder, quantum and thermal fluctuations in ferromagnetic alloys: The case of UCu2Si(2-x)Ge(x)

We consider, theoretically and experimentally, the effects of structural disorder, quantum and thermal fluctuations in the magnetic and transport properties of certain ferromagnetic alloys.We study the particular case of UCu2Si(2-x)Ge(x). The low temperature resistivity, rho(T,x), exhibits Fermi liquid (FL) behavior as a function of temperature T for all values of x, which can be interpreted as a result of the magnetic scattering of the conduction electrons from the localized U spins. The residual resistivity, rho(0,x), follows the behavior of a disordered binary alloy. The observed non-monotonic dependence of the Curie temperature, Tc(x), with x can be explained within a model of localized spins interacting with an electronic bath whose transport properties cross-over from ballistic to diffusive regimes. Our results clearly show that the Curie temperature of certain alloys can be enhanced due to the interplay between quantum and thermal fluctuations with disorder.Comment: 4 pages, 3 figures, to appear in Phys. Rev. Let

Skyrmions in a Doped Antiferromagnet

Magnetization and magnetoresistance have been measured in insulating antiferromagnetic La_{2}Cu_{0.97}Li_{0.03}O_{4} over a wide range of temperatures, magnetic fields, and field orientations. The magnetoresistance step associated with a weak ferromagnetic transition exhibits a striking nonmonotonic temperature dependence, consistent with the presence of skyrmions.Comment: 4+ pages, 3 figures (some low resolution), supplementary material (3 pages); discussion expanded, references added; as publishe

Extraordinary magnetoresistance in graphite: experimental evidence for the time-reversal symmetry breaking

The ordinary magnetoresistance (MR) of doped semiconductors is positive and quadratic in a low magnetic field, B, as it should be in the framework of the Boltzmann kinetic theory or in the conventional hopping regime. We observe an unusual highly-anisotropic in-plane MR in graphite, which is neither quadratic nor always positive. In a certain current direction MR is negative and linear in B in fields below a few tens of mT with a crossover to a positive MR at higher fields, while in a perpendicular current direction we observe a giant super-linear and positive MR. These extraordinary MRs are respectively explained by a hopping magneto-conductance via non-zero angular momentum orbitals, and by the magneto-conductance of inhomogeneous media. The linear orbital NMR is a unique signature of the broken time-reversal symmetry (TRS) in graphite. While some local paramagnetic centers could be responsible for the broken TRS, the observed large diamagnetism suggests a more intriguing mechanism of this breaking, involving superconducting clusters with unconventional (chiral) order parameters and spontaneously generated normal-state current loops in graphite.Comment: 4 pages, 5 figure

Logarithmic behavior of degradation dynamics in metal--oxide semiconductor devices

In this paper the authors describe a theoretical simple statistical modelling of relaxation process in metal-oxide semiconductor devices that governs its degradation. Basically, starting from an initial state where a given number of traps are occupied, the dynamics of the relaxation process is measured calculating the density of occupied traps and its fluctuations (second moment) as function of time. Our theoretical results show a universal logarithmic law for the density of occupied traps $\bar{} \sim \phi (T,E_{F}) (A+B \ln t)$, i.e., the degradation is logarithmic and its amplitude depends on the temperature and Fermi Level of device. Our approach reduces the work to the averages determined by simple binomial sums that are corroborated by our Monte Carlo simulations and by experimental results from literature, which bear in mind enlightening elucidations about the physics of degradation of semiconductor devices of our modern life

Bounds on gamma from CP violation measurements in B -> pi+ pi- and B -> psi K_S

We study the determination of gamma from CP-violating observables in B -> pi+ pi- and B -> psi K_S. This determination requires theoretical input to one combination of hadronic parameters. We show that a mild assumption about this quantity may allow bounds to be placed on gamma, but we stress the pernicious effects that an eightfold discrete ambiguity has on such an analysis. The bounds are discussed as a function of the direct (C) and interference (S) CP-violating observables obtained from time-dependent B -> pi+ pi- decays, and their behavior in the presence of new physics effects in B-Bbar mixing is studied. (V2: Misprints corrected. Slightly improved discussion.)Comment: 11 pages, RevTex 4, 5 eps figures include

Growth of seven perennial plant species adapted to the Brazilian Semi-Arid.

Growth of seven perennial plant species adapted to the Brazilian Semi-Arid. Abstract - Measuring plant height (y) and canopy diameter (x) in trees may not be an easy task, but stem diameter (z) can be more easily evaluated. This work's objective was two-fold: evaluate the growth of species adapted to the Brazilian Semi-Arid Region in the first two years of age, and obtain linear equations to estimate y and x from z, in those species. A random block design with four replications was employed. The values for x, z, and y were measured biannually from October/2003 to March/2005. Prosopis juliflora and Mimosa caesalpiniaefolia showed the highest stem diameter and plant height values, respectively, and both showed the highest canopy diameter. In the equations to estimate plant height from the stem diameter the value of the coefficient of determination (R2) ranged from 0.76 (Tamarindus indica and Leucaena leucocephala) to 0.92 (Prosopis juliflora and Azadirachta indica). In the equations that allowed to estimate the crown diameter from the stem diameter the R2 value ranged from 0.70 (Leucaena leucocephala) to 0.92 (Azadirachta indica). Crescimento de sete espécies vegetais perenes adaptadas ao Semi-Árido brasileiro. Resumo - A mensuração da altura da planta (y) e do diâmetro da copa (x) em árvores pode não ser tarefa fácil, mas o diâmetro do caule (z) pode ser avaliado mais facilmente. Este trabalho teve por objetivos avaliar o crescimento de espécies adaptadas ao Semi-Árido brasileiro, nos primeiros dois anos de idade, e obter equações lineares para estimar y e x a partir de z, nessas espécies. Utilizou-se o delineamento de blocos ao acaso com quatro repetições. Os valores de x, z e y foram medidos semestralmente de outubro/2003 a março/2005. Prosopis juliflora e Mimosa caesalpiniaefolia apresentaram os maiores diâmetros do caule e altura da planta, respectivamente, e ambas apresentaram o maior diâmetro da copa. Nas equações para estimar a altura da planta a partir do diâmetro do caule, o valor do coeficiente de determinação (R2) variou de 0,76 (Tamarindus indica and Leucaena leucocephala) a 0,92 (Prosopis juliflora and Azadirachta indica). Nas equações que permitiram estimar o diâmetro da copa a partir do diâmetro do caule, o valor de R2 variou de 0,70 (Leucaena leucocephala) a 0,92 (Azadirachta indica)

Notes on the Two-brane Model with Variable Tension

Motivated by possible extensions of the braneworld models with two branes, we investigate some consequences of a variable brane tension using the well established results on consistency conditions. By a slight modification of the usual stress-tensor used in order to derive the braneworld sum rules, we find out some important constraints obeyed by time dependent brane tensions. In particular it is shown that the tensions of two Randall-Sundrum like branes obeying, at the same time, an Eotvos law, aggravate the fine tuning problem. Also, it is shown that if the hidden brane tension obeys an Eotvos law, then the visible brane has a mixed behavior allowing a bouncing-like period at early times while it is dominated by an Eotvos law nowadays. To finalize, we discuss some qualitative characteristics which may arise in the scope of dynamical brane tensions, as anisotropic background and branons production.Comment: 7 pages, 1 figure, accepted for publication in Physical Review