Towards the electron EDM search. Theoretical study of PbF

We report ab initio relativistic correlation calculations of potential curves and spectroscopic constants for four lowest-lying electronic states of the lead monofluoride. We also calculated parameters of the spin-rotational Hamiltonian for the ground and the first excited states including P,T-odd and P-odd terms. In particular, we have obtained hyperfine constants of the $^{207}$Pb nucleus. For the $^2\Pi_{1/2}$ state $A_\perp=-6859.6$ MHz, $A_\|=9726.9$ MHz and for the A$^2\Sigma^+_{1/2}$ $A_\perp=1720.8$ MHz, $A_\|=3073.3$ MHz. Our values of the ground state hyperfine constants are in good agreement with the previous theoretical studies. We discuss and explain seeming disagreement in the sign of the constant $A_\perp$ with the recent experimental data. The effective electric field on the electron $E_{eff}$, which is important for the planned experiment to search for the electric dipole moment of the electron, is found to be 3.3 * 10^{10} V/cm

On Nonperturbative Calculations in Quantum Electrodynamics

A new approach to nonperturbative calculations in quantum electrodynamics is proposed. The approach is based on a regular iteration scheme for solution of Schwinger-Dyson equations for generating functional of Green functions. The approach allows one to take into account the gauge invariance conditions (Ward identities) and to perform the renormalization program. The iteration scheme can be realized in two versions. The first one ("perturbative vacuum") corresponds to chain summation in the diagram language. In this version in four-dimensional theory the non-physical singularity (Landau pole) arises which leads to the triviality of the renormalized theory. The second version ("nonperturbative vacuum") corresponds to ladder summation and permits one to make non-perturbative calculations of physical quantities in spite of the triviality problem. For chiral-symmetrical leading approximation two terms of the expansion of the first-step vertex function over photon momentum are calculated. A formula for anomalous magnetic moment is obtained. A problem of dynamical chiral symmetry breaking (DCSB) is considered, the calculations are performed for renormalized theory in Minkowsky space. In the strong coupling region DCSB-solutions arise. For the renormalized theory a DCSB-solution is also possible in the weak coupling region but with a subsidiary condition on the value of $\alpha$.Comment: 31 pages, Plain LaTex, no figures. Journal version: some discussion and refs. are adde

Лимфаденэктомия у больных раком почки

Sixty hundred and twenty-six case histories of patients with renal-cell carcinoma, who underwent nephrectomy at the Department of Oncourology, P.A. Herzen Moscow Research Oncological Institute, in November 1992 to November 2005, have been restrospectively analyzed.Results. Metastatic lymph nodal lesion was identified in 23 (6.49%) patients of 354 patients with renal-cell carcinoma without distant metastasis, who had undergone regional lymphadenectomy. Metastatic regional lymph nodal lesions were found in 9 (2.54%) patients on preoperative examination (as verified by ultrasound study and computed tomography). Metastatic lymph nodal lesion was intraoperatively suspected in 3 (0.85%) patients. This was revealed in 11 (3.11%) patients after planned histological study.Conclusion. The frequency of metastatic regional lymph nodal lesions is 3.11% in patients with early renal-cell carcinoma with unaltered regional lymph nodes, as shown by preoperative and operative examinations. In renal-cell carcinoma, the probability of metastasis into the regional lymph nodes increases in patients with a more 5-cm renal tumor, in those with non-clear or mixed carcinoma, and or those with a locally advanced tumorous process.

A Unifying Model of Genome Evolution Under Parsimony

We present a data structure called a history graph that offers a practical basis for the analysis of genome evolution. It conceptually simplifies the study of parsimonious evolutionary histories by representing both substitutions and double cut and join (DCJ) rearrangements in the presence of duplications. The problem of constructing parsimonious history graphs thus subsumes related maximum parsimony problems in the fields of phylogenetic reconstruction and genome rearrangement. We show that tractable functions can be used to define upper and lower bounds on the minimum number of substitutions and DCJ rearrangements needed to explain any history graph. These bounds become tight for a special type of unambiguous history graph called an ancestral variation graph (AVG), which constrains in its combinatorial structure the number of operations required. We finally demonstrate that for a given history graph $G$, a finite set of AVGs describe all parsimonious interpretations of $G$, and this set can be explored with a few sampling moves.Comment: 52 pages, 24 figure

ГОРМОНАЛЬНАЯ ТЕРАПИЯ ПРЕПАРАТОМ ЛЕЙПРОРЕЛИН (ЛЮКРИН-ДЕПО®) У БОЛЬНЫХ РАКОМ ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ

Leuproprelin acetate (Lucrin-depot) is an efficacious and safe luteinizing hormone-releasing hormone analogue, the efficiency of which has been proven in a number of large clinical studies. The agent exhibits a sustained release, is easy-to-use and well-tolerated, and causes minimal side effects. Lucrin-depot may be recommended for use as alone and in combination with other hormonal agents in patients with prostate cancer if androgenic deprivation is indicated.Лейпропрелина ацетат (Люкрин-депо) — результативный и безопасный аналог лютеинизирующего гормона рилизинггормона, эффективность которого доказана в ряде крупных клинических исследований. Препарат оказывает пролонгированное действие, удобен в использовании, дает минимальные побочные эффекты и хорошо переносится больными. Люкрин-депо может быть рекомендован для применения в качестве самостоятельной терапии или в комбинации с другими гормональными препаратами у пациентов с раком предстательной железы при наличии показаний к проведению андрогенной депривации

Sampling and counting genome rearrangement scenarios

Even for moderate size inputs, there are a tremendous number of optimal rearrangement scenarios, regardless what the model is and which specific question is to be answered. Therefore giving one optimal solution might be misleading and cannot be used for statistical inferring. Statistically well funded methods are necessary to sample uniformly from the solution space and then a small number of samples are sufficient for statistical inferring

Ударные волны в релятивистском газе

The problem of shock waves propagation in ultra-relativistic media is considered. A system of transport equations for shock waves is obtained on the basis of the non-local relativistic hydrodynamic theory. Numerical solution of these equations is applied for analyzing the structure of the transition layer using different boundary conditions.Рассматривается задача о распространении ударных волн в ультрарелятивистской среде. На основе нелокальной релятивистской гидродинамической теории получена система уравнений для ударных волн. Численное решение этих уравнений позволило проанализировать структуру переходного слоя ударных волн при различных условиях

ПЕРВИЧНО-МНОЖЕСТВЕННЫЕ ЗЛОКАЧЕСТВЕННЫЕ НОВООБРАЗОВАНИЯ С ПОРАЖЕНИЕМ МОЧЕПОЛОВЫХ ОРГАНОВ

The incidence of polyneoplasia was studied among the urban and rural populations of the Omsk Region. Urinary tract neoplasms constitute 10% of the total structure of cancer morbidity, these occurring twice more frequently in the urban population than in the rural one. Polyneoplasias involving the urinary tract are metachronous in 62.8%, synchronous in 35.2%, metachronous-and-synchronous in 1.2%, and synchronous-and-metachronous in 0.8%. Out of 253 patients with polyneoplasia involving the urinary tract, 176 (69.6%) died and 77 (30.4%) survived during 8 years.Изучена частота первично-множественного рака среди городского и сельского населения Омской области. Новообразования мочеполовых органов в общей структуре онкологической заболеваемости составляют 10%, причем среди городского населения они встречаются в 2 раза чаще, чем среди сельского. Первично-множественные злокачественные опухоли с поражением мочеполовых органов в 62,8% случаев являются метахронными, в 35,2% - синхронными, в 1,2% - метахронно-синхронными и в 0,8% - синхронно-метахронными. В течение 8 лет из 253 пациентов с первично-множественным раком с поражением мочеполовых органов умерло 176 человек (69,6%), живы 77 человек (30,4%)

Таксотер® — новый стандарт лечения гормонорефрактерного рака предстательной железы

One of the options in the treatment of hormone-refractory prostate cancer is the administration of cytostatic agents. This article addresses the Taxoter — one of the cytostatic agents. Clinical studies discussed in the article have demonstrated the high activity and efficacy of the agent which allows using it in the treatment of hormone-refractory prostate cancer.