Application of the resonant recognition model to analysis of interaction between viral and tumor suppressor proteins

Recent findings in cancer research has established a connection between a T-antigen - common virus - and a brain tumor in children. The studies suggested the T-antigen, the viral component of a specific virus, called the JC virus, plays a significant role in the development of the most frequent type of malignant brain tumors by blocking the functionality of tumor suppressor proteins such as p53 and pRb. Here we have investigated the structure and function relationships of T-antigen, p53 and pRb proteins using the Resonant Recognition Model (RRM), a physico-mathematical approach based on digital signal processing methods

Investigation of the structural and functional relationships of oneogene proteins

Proteins are the biomolecular workhorses driving the most biological processes in any living organism. These processes are based on selective interactions between particular proteins. So far, the rules governing the coding of the protein's biological function, i.e. its ability to selectively interact with other biomolecules, have not been elucidated. The resonant recognition model (RRM) is a novel physicomathematical approach established to analyze the interaction between a protein and its target. The RRM assumes that the specificities of protein interactions are based on the resonant electromagnetic energy transfer at the specific frequency for each interaction. One of the main applications of this model is to predict the location of a protein's biological active site(s) using digital signal processing. This paper incorporates the continuous wavelet transform (CWT) into the RRM to predict the active sites, for a chosen protein example. We have investigated the oncogene functional group using digital signal analysis methods, in particular Fourier transform and CWT; determined oncogenes' characteristic frequency and functional active sites; and performed the design of the peptide analogous. The results obtained provide new insights into the structure-function relationships of the analyzed oncogene protein family

Evaluasi Perhitungan Angsuran Pajak Penghasilan Pasal 25 dan Penerapan Akuntansi Pada PT. Jobroindo Makmur

Pajak Penghasilan Pasal 25 merupakan salah satu jenis pajak yang bersifat angsuran yang dimana bertujuan untuk meringankan beban pajak perusahaan. Tujuan dari penelitian ini adalah untuk mengevaluasi perhitungan angsuran pajak penghasilan pasal 25 dan penerapan akuntansinya yang ada pada PT. Jobroindo Makmur. Metode penelitian yang digunakan dalam penelitian ini yaitu metode kualitatif deskriptif, sedangkan metode pengumpulan data dilakukan dengan wawancara dan dokumentasi. Hasil dari penelitian ini adalah PT. Jobroindo Makmur telah melakukan perhitungan angsuran pajak penghasilan pasal 25 dengan benar dan melakukan penerapan akuntansinya dengan benar, serta dalam penelitian ini ditemukan bahwa PT. Jobroindo Makmur telah menerapkan fasilitas angsuran pajak penghasilan pasal 25 sebesar 22% yang dimana telah dilakukan dengan benar

Energy sinks: vibration absorption by an optimal set of undamped oscillators

This paper describes a new concept referred to here as “energy sinks” as an alternative to conventional methods of vibration absorption and damping. A prototypical energy sink envisioned here consists of a set of oscillators attached to, or an integral part of, a vibrating structure. The oscillators that make up an energy sink absorb vibratory energy from a structure and retain it in their phase space. In principle, energy sinks do not dissipate vibratory energy as heat in the classical sense. The absorbed energy remains in an energy sink permanently (or for sufficiently long durations) so that the flow of energy from the primary structure appears to it as damping. This paper demonstrates that a set of linear oscillators can collectively absorb and retain vibratory energy with near irreversibility when they have a particular distribution of natural frequencies. The approach to obtain such a frequency distribution is based on an optimization that minimizes the energy retained by the structure as a function of frequency distribution of the oscillators in the set. The paper offers verification of such optimal frequency spectra with numerical simulations and physical demonstrations

Experiments on vibration absorption using energy sinks

This paper presents experiments that demonstrate the concept of energy sinks, which when attached to a vibrating structure can absorb most of its energy. Energy sinks consist of a set of undamped linear oscillators and, in principle, do not require presence of damping in the classical sense. The set of undamped oscillators that make up an energy sink collectively absorb the vibratory energy and retain it in their phase space. Earlier optimization studies by the authors have shown the feasibility of vibration absorption and energy retention by energy sinks if the set of oscillators have a particular frequency distribution. Experimental results presented in this paper support the concept of energy sinks. Different physical realizations of energy sinks demonstrate the significance of frequency distributions and the ability of energy sinks to reduce vibration amplitude of a primary structure to which they are attache

Review of Linac-Ring Type Collider Proposals

There are three possibly types of particle colliders schemes: familiar (well known) ring-ring colliders, less familiar however sufficiently advanced linear colliders and less familiar and less advanced linac-ring type colliders. The aim of this paper is two-fold: to present possibly complete list of papers on linac-ring type collider proposals and to emphasize the role of linac-ring type machines for future HEP research.Comment: quality of figures is improved, some misprints are correcte

Sex Stereotypes of Adolescents in Traffic: The Role of Sex and Family Relationships (Trafikte Ergenlerin Cinsiyet Kalıp Yargıları: Cinsiyet ve Aile İlişkilerinin Rolü)

Studies have shown a number of differences between male and female drivers, such as male drivers committing more offenses and female drivers making more errors. Related to this persistent sex difference, relatively little research has been conducted to examine the presence of gender stereotypes and determinants in the context of driving. This study examined the perceptions of female and male drivers among adolescents in Türkiye and how sex differences and relationships with parents contributed to the endorsement of sex stereotypes. The study was conducted with 128 high school adolescents aged 15-20 years (M = 16.25, SD = 1.32) who completed a questionnaire package consisting of the Sex Stereotypes Associated with Driving (SSAD) and a demographic information form. In terms of sex stereotype endorsement indices, female adolescents reported female drivers as more polite and risk-averse, whereas male adolescents reported male drivers as more skilled. While a positive relationship with fathers reduced the endorsement of courtesy and risk-avoidance stereotypes, a better relationship with mothers resulted in a lower endorsement of the driving skills stereotype. The results provide evidence for the existence of sex stereotypes among adolescents and for the importance of family relationships in relation to sex stereotype endorsement. The findings can be used to design training and education that focuses on stereotypes at an early age. (Araştırmalar, erkek ve kadın sürücüler arasında, erkek sürücülerin daha fazla trafik cezası alması ve kadın sürücülerin daha fazla hata yapması gibi bir dizi farklılık olduğunu göstermektedir. Gözlemlenen bu cinsiyet farklılığına bağlı olarak, sürüş bağlamında toplumsal cinsiyet kalıp yargılarının ve belirleyicilerinin varlığını inceleyen nispeten az sayıda araştırma yapılmıştır. Bu çalışma, Türkiye'deki ergenlerin kadın ve erkek sürücü algılarını ve cinsiyet farklılıklarının ve ebeveynlerle ilişkilerin cinsiyet kalıp yargılarının onaylanmasına nasıl katkıda bulunduğunu incelemiştir. Çalışma, Sürücülükle İlişkili Cinsiyet Kalıp Yargıları (SSAD) ve demografik bilgi formundan oluşan bir anket paketini dolduran 15-20 yaş arası 128 lise çağındaki ergen (M = 16.25, SD = 1.32) ile yürütülmüştür. Cinsiyet stereotipi onay endeksleri açısından, kız ergenler kadın sürücüleri daha kibar ve riskten kaçınan olarak bildirirken, erkek ergenler erkek sürücüleri daha becerikli olarak bildirmiştir. Babalarla olumlu bir ilişki nezaket ve riskten kaçınma kalıp yargılarının onaylanmasını azaltırken, annelerle daha iyi bir ilişki sürüş becerileri kalıp yargısının daha az onaylanmasıyla sonuçlanmıştır. Sonuçlar, ergenler arasında cinsiyet kalıp yargılarının varlığına ve aile ilişkilerinin cinsiyet kalıp yargılarının onaylanması açısından önemine dair kanıtlar sunmaktadır. Bulgular, erken yaşta kalıp yargılara odaklanan eğitim ve müdahale çalışmalarının tasarlanmasında kullanılabilir.

Behavioural intention of e-scooter use: A comparison of users and non-users

In the present study, the behavioural intention and factors affecting the use of e-scooters were examined among young people in Turkey. Previous users and non-users of e-scooters were compared in relation to the various variables. The relationships of attitudes, subjective norms, perceived behavioural control, and perceived usefulness were investigated regarding the intention to use e-scooters. While users reported positive socio-psychological factors related to e-scooter use, all different factors were positively related to behavioural intention. The results highlighted the importance of socio-psychological factors in predicting behavioural intention, as well as differences between e-scooter users and non-users in these factors

DETERMINING THE LOCATIONS OF POTENTIAL FIREFIGHTING TEAMS BY USING GIS TECHNIQUES

Wild forest fires are one of the most important disasters that affect the forest ecosystem especially in the regions with arid climate conditions. Besides, forest fires threats human life and results in seriously property loss. In order to fight forest fires effectively, it is crucial that firefighting team should reach fire location and start fire extinguishing activities within the critical response time. Since firefighting teams are transported to fire locations by fire-trucks, the optimum route with minimum travel time should be determined by considering available road network. “New Service Area” tool under “Network Analyst” extension of ArcGIS can be used to determine a region that can be reached from a point within a specified time period. In this study, it was aimed to evaluate the locations of current firefighting teams and investigate locations of potential firefighting teams using “New Service Area” tool. The study area is located in Mustafakemalpaşa in Bursa where forest lands are sensitive to forest fires at the second degree and there is currently one firefighting team in the area. The results indicated that 31.28% of forest land can be reached by current firefighting team within the critical response time. When including new firefighting teams, it was found that accessible forest lands increased to 71.55%. It can be concluded that locating new firefighting teams should be established in the study area to increase the accessible forested areas on time and GIS-based decision support systems can be effectively used to fight forest fires regarding with disaster management

ROAD EXTRACTION TECHNIQUES FROM REMOTE SENSING IMAGES: A REVIEW

The importance of analysis high resolution satellite imagery plays an important research topic for geographical information analysis of cities. Geospatial data plays an important role in important issues such as governmental, industrial, research topics on traffic management, road monitoring, GNSS navigation, and map updating. In this study, road detection from satellite imagery methods are classified as classification-based, knowledge-based, mathematical morphology and dynamic programming. In the beginning, the road structures including feature and model are analyzed. Then, the advantages and disadvantages of road detection methods are evaluated and summarizes their accuracy and performance based on road detection principles. Therefore, in order to obtain remarkable results for road detection, it is better to use more than one method. In after days, performing a complex road extraction from a satellite image is still a necessary and important research topic