Современные возможности лапароскопической пластики мочепузырно-прямокишечного свища

Современные возможности лапароскопической пластики мочепузырно-прямокишечного свищ

Revisiting the Incorporation of Ti(IV) in UiO-type Metal–Organic Frameworks: Metal Exchange versus Grafting and Their Implications on Photocatalysis

Revisiting the Incorporation of Ti(IV) in UiO-type Metal–Organic Frameworks: Metal Exchange versus Grafting and Their Implications on Photocatalysi

Cyclic Nucleotide Phosphodiesterases and Compartmentation in Normal and Diseased Heart

International audienceCyclic nucleotide phosphodiesterases (PDEs) degrade the second messengers cAMP and cGMP, thereby regulating multiple aspects of cardiac function. This highly diverse class of enzymes encoded by 21 genes encompasses 11 families which are not only responsible for the termination of cyclic nucleotide signalling, but are also involved in the generation of dynamic microdomains of cAMP and cGMP controlling specific cell functions in response to various neurohormonal stimuli. In myocardium, the PDE3 and PDE4 families are predominant to degrade cAMP and thereby regulate cardiac excitation-contraction coupling. PDE3 inhibitors are positive inotropes and vasodilators in human, but their use is limited to acute heart failure and intermittent claudication. PDE5 is particularly important to degrade cGMP in vascular smooth muscle, and PDE5 inhibitors are used to treat erectile dysfunction and pulmonary hypertension. However, these drugs do not seem efficient in heart failure with preserved ejection fraction. There is experimental evidence that these PDEs as well as other PDE families including PDE1, PDE2 and PDE9 may play important roles in cardiac diseases such as hypertrophy and heart failure. After a brief presentation of the cyclic nucleotide pathways in cardiac cells and the major characteristics of the PDE superfamily, this chapter will present their role in cyclic nucleotide compartmentation and the current use of PDE inhibitors in cardiac diseases together with the recent research progresses that could lead to a better exploitation of the therapeutic potential of these enzymes in the future

The Se<inf>2</inf> (Gas) Fugacity in Systems with Noble Metals: Chrisstanleyite Ag<inf>2</inf>Pd<inf>3</inf>Se<inf>4</inf> – Naumannite Ag<inf>2</inf>Se–β-PdSe<inf>2</inf> and Luberoite Pt<inf>5</inf>Se<inf>4</inf>–Sudovikovite PtSe<inf>2</inf>

© 2019, Pleiades Publishing, Ltd. Abstract: The reactions of 6Ag(cr) + 3PdSe2(cr) = 2Ag2Se(cr) + Ag2Pd3Se4(cr) and 12Ag(cr) + 5PtSe2(cr) = 6Ag2Se(cr) + Pt5Se4(cr) were studied with the EMF method in a completely solid-state galvanic cell with an Ag ion-conducting solid electrolyte with overall gas space (argon under atmospheric pressure). The EMF vs. temperature dependencies were obtained in the temperature ranges of Т = 425–648 K and 501–713 K, respectively. Then, they were recalculated for gaseous Se fugacity in dependence on the temperature for nonvariant equilibriums of Ag2Pd3Se4 (chrisstanleyite)–β-PdSe2 (the phase, which transforms into verbeekite under low temperatures)–Ag2Se (naumannite) and Pt5Se4 (luberoite)–PtSe2 (sudovikovite): logf Se2(gas) (Ag2Pd3Se4/Ag2Se/PdSe2) = 7.710 ± 0.050 – 8.524 ± 0.026(1000/T), logfSe2(gas) (Pt5Se4/PtSe2) = 7.135 ± 0.027 – 12.274 ± 0.016(1000/T)

The Se<inf>2</inf> (Gas) Fugacity in Systems with Noble Metals: Chrisstanleyite Ag<inf>2</inf>Pd<inf>3</inf>Se<inf>4</inf> – Naumannite Ag<inf>2</inf>Se–β-PdSe<inf>2</inf> and Luberoite Pt<inf>5</inf>Se<inf>4</inf>–Sudovikovite PtSe<inf>2</inf>

© 2019, Pleiades Publishing, Ltd. Abstract: The reactions of 6Ag(cr) + 3PdSe2(cr) = 2Ag2Se(cr) + Ag2Pd3Se4(cr) and 12Ag(cr) + 5PtSe2(cr) = 6Ag2Se(cr) + Pt5Se4(cr) were studied with the EMF method in a completely solid-state galvanic cell with an Ag ion-conducting solid electrolyte with overall gas space (argon under atmospheric pressure). The EMF vs. temperature dependencies were obtained in the temperature ranges of Т = 425–648 K and 501–713 K, respectively. Then, they were recalculated for gaseous Se fugacity in dependence on the temperature for nonvariant equilibriums of Ag2Pd3Se4 (chrisstanleyite)–β-PdSe2 (the phase, which transforms into verbeekite under low temperatures)–Ag2Se (naumannite) and Pt5Se4 (luberoite)–PtSe2 (sudovikovite): logf Se2(gas) (Ag2Pd3Se4/Ag2Se/PdSe2) = 7.710 ± 0.050 – 8.524 ± 0.026(1000/T), logfSe2(gas) (Pt5Se4/PtSe2) = 7.135 ± 0.027 – 12.274 ± 0.016(1000/T)