Complex of Chemical-technological and Sanitary-hygienic Quality Indicators of the New Pastry Products of Special Nutrition

The complex of chemical-technological and sanitary-hygienic quality indicators of new pastry products of special nutrition was studied. The original recipes of meat pastries for special nutrition, enriched with biologically active components at the expanse of vitaminized blended vegetable oils (VBVO) and protein-fatty emulsions (PFE) on their base, were elaborated. There were elaborated four recipes of pastries of chicken and Turkey with PFE, included in recipes in the amount 15…20 % and with vitaminized blended vegetable oils of two-component and three-component composition in the amount 10 %. Pastry samples, prepared according to SSTC 4432:2005 were used as a control.VBVO composition and fat-soluble vitamins content in them was determined by the gasochromatographic method.Molecular-genetic methods were used for the accelerated diagnostics of pastries safety by agents of food intoxications– Clostridium perfringens and Bacillus cereus, number of mesophyl aerobic and facultative-anaerobic microorganisms (NMAFAnM), classic ones – colon bacillus group bacteria (CBGB), sulphite reductive clostridia, Staphylococcus aureus, L.monocytogenes, Salmonella. The storage term of products was prolonged in 2 times (48 against 24 hours) according to SSTC). The expedience of their introduction in production was proved

МЕТОДИКА МОДЕЛЮВАННЯ ІНДИВІДУАЛЬНОГО ЖИТЛОВОГО БУДИНКУ ТА СТВОРЕННЯ АНІМАЦІЙНИХ ПОСЛІДОВНОСТЕЙ ДЛЯ ПРЕЗЕНТАЦІЙ В СИСТЕМІ ОРГАНІЗАЦІЇ НАВЧАЛЬНОГО ПРОЦЕСУ У ВИЩІЙ ШКОЛІ ДЛЯ СТУДЕНТІВ АРХІТЕКТУРНО–БУДІВЕЛЬНОГО НАПРЯМКУ

In the article the expansion of technologically advanced training in the modern development of computer science and information technology. The current level of development and preparation of engineering and design documentation involves the use of computer graphics systems, which can significantly increase the efficiency, quality and speed of creation and implementation of civil and industrial projects. Learning and mastering graphic system AutoCAD, which is one of the most common computer systems engineering level is based in particular on methodical maintenance of laboratory and practical training in engineering and computer graphics. Therefore, the work presented, which provides training material for filling methodical course of computer graphics has relevance in the learning process.  В статье рассматривается расширение практики с использованием новейших технологий обучения в условиях современного развития информатики и информационных технологий. Современный уровень разработки и подготовки инженерно–конструкторской документации предполагает использование компьютерных графических систем, которые существенно повышают эффективность, качество, скорость разработки строительных и промышленных проэктов. Изучение и применение студентами графической системы AutoCAD базируется на методическом обеспечении лабораторных и практических занятий по инженерной и компьютерной графике. Поэтому, представленная работа – подготовка материала для методического наполнения курса компьютерной графики, актуальна в учебном процессе.В статті розглядається розширення практики з використанням новітніх технологій навчання в умовах сучасного розвитку інформатики та інформаційних технологій. Сучасний рівень розробки та підготовки інженерно–конструкторської документації передбачає застосування комп’ютерних графічних систем, які дозволяють суттєво підвищити ефективність, якість та швидкість створення та впровадження будівельних та промислових проектів. Вивчення та засвоєння студентами графічної системи AutoCAD, яка являється однією з найпоширеніших комп’ютерних систем інженерного рівня, базується, зокрема, на методичному забезпеченні лабораторних та практичних занять з інженерної та комп’ютерної графіки. Тому, представлена робота, яка передбачає підготовку матеріалу для методичного наповнення курсу комп’ютерної графіки, має актуальність у навчальному процесі. &nbsp

PECULIARITIES OF NEPHROPROTECTIVE EFFECT OF SULODEXIDE IN PATIENTS WITH DIABETIC NEPHROPATHY

Introduction. Monocyte chemoattractant protein type 1 (MCP-1) and plasminogen activator inhibitor type 1 (PAI-1) play a key role in inflammation, fibrosis and progression of renal dysfunction. Sulodexide advantages in vascular pathology treatment were proved by clinical trials, however, its efficiency in diabetic nephropathy (DN) was investigated insufficiently. The aim of the present work – to study the influence of sulodexide on clinical and laboratory parametres, MCP-1 and PAI-1 levels in blood plasma of patients with DN. Materials and methods. 76 type 2 diabetic patients with different stages of DN were observed. 44 patients received basic therapy with anti-diabetic drugs and ACE- inhibitors, 32 patients in addition to basic therapy were treated with sulodexide in a daily dose 600 LU. Concentrations of MCP-1 and PAI-1 in blood plasma were determined using immunoassay kits. Results. In patients with DN when compared with healthy controls MCP-1 and RAI-1 levels in blood plasma significantly increased already at initial stages of the disease. Such changes may promote a development of inflammatory and fibrotic processes in kidneys. Progression of the disease was accompanied by more essential growth of MCP-1 and RAI-1 in DN patients with expressed clinical manifestations of kidney injury. Sulodexide treatment in patients with DN resulted in essential decrease of inflammatory and fibrotic markers and had positive effect on urinary protein excretion. Conclusions. Glicosaminoglycans, in particular, sulodexide, is effective in complex treatment of patients with DN

ПЕРСПЕКТИВИ ВИКОРИСТАННЯ КЛІТКОВИНИ У ВИРОБНИЦТВІ М'ЯСНИХ ПРОДУКТІВ

Balanced diet is an essential factor in maintaining the normal life of a healthy body. The importance of nutrition in preventive and reducing major risk factors of disease is provided by the specialized functionality. The range of functional foods is limited. Moreover, the majority accounts for products is enriched preparations of pharmacological action and imported supplements. Thus, the task of creating a new functional products with the aim of improving the structure of power is becoming extremely urgent. In particular, those products are supposed to be based on meat. In the article the possibility of using different types of fiber in the manufacture of chopped semi-finished products was grounded. Functional and technological properties of the selected components were investigated. It was found that in the formulation is chopped to include semi rational fiber from millet and barley bran in an amount of up to 3% and the degree of hydration of 1: 6 and 1: 4.5 respectively.  Сбалансированное питание является необходимым фактором поддержания нормальной жизнедеятельности здорового организма.Важное значение в профилактическом питании и снижении основных факторов риска возникновения болезней предоставляется специализированным функциональным продуктам.Ассортимент функциональных продуктов ограничен, причем основная часть приходится на продукты, обогащенные препаратами фармакологического действия и импортные пищевые добавки. В связи с этим чрезвычайно актуальной становится задача по созданию новых функциональных продуктов с целью улучшения структуры питания, в частности, продуктов на основе мяса.В статье обоснована возможность использования различных видов клетчатки при производстве рубленых полуфабрикатов. Исследованы функционально-технологические свойства выбранных компонентов и установлено, что рациональнее в рецептуры рубленых полуфабрикатов включать клетчатку из отрубей проса и ячменя в количестве до 3% и степенью гидратации 1: 6 и 1: 4,5 соответственно.Збалансоване харчування є необхідним чинником підтримання нормальної життєдіяльності здорового організму. Важливе значення в профілактичному харчуванні та зниженні основних факторів ризику виникнення хвороб надається спеціалізованим функціональним продуктам. Асортимент функціональних продуктів обмежений, причому основна частка припадає на продукти, збагачені препаратами фармакологічної дії та імпортні харчові добавки. У  зв'язку з цим надзвичайно актуальним стає завдання по створенню нових функціональних продуктів з метою поліпшення структури харчування, зокрема, продуктів на основі м'яса. У статті обґрунтовано  можливість  використання різних видів клітковини  при виробництві січених напівфабрикатів. Досліджено функціонально-технологічні властивості обраних компонентів та встановлено, що раціональніше у рецептури січених напівфабрикатів включати клітковину з відрубів проса та ячменю в кількості до 3% та  ступенем гідратації  1:6 та 1:4,5 відповідно. &nbsp

Информация о смерти клеток необходима для жизни всего организма

In present paper we give the review of own experimental and literary data, devoted to programmed cells destruction— apoptosis in animal and plants. We show, that the inheritable information about cell death is necessary for life and evolutionary prosperity of multicellular organisms.В настоящей статье мы даем обзор собственных экспериментальных и литературных данных, посвященных запрограммированной гибели клеток — апоптозу у животных и растений, показываем, что наследственная информация о смерти необходима для жизни и эволюционного процветания многоклеточных организмов. За эти работы группе американских и английских учёных в 2002 г. была присуждена Нобелевская премия по физиологии и медицине. Апоптоз — центральная проблема современного комплекса наук о жизни

Cyanothioacetamides as a synthetic platform for the synthesis of aminopyrazole derivatives

It was shown that the reaction of 2-cyanothioacetamides with hydrazine involves both cyano- and thioamide groups, and 3,5-diaminopyrazoles are formed. In the reaction of 2-cyano-3-(dimethylamino)-N,N-dimethylprop-2-enethioamides with hydrazine and its derivatives, the interaction proceeds with the participation of cyano- and enamine groups, not affecting the thiocarbamoyl group, and leads to the formation of 4-thiocarbamoylpyrazoles. A synthesis method has been developed and a series of 1-substituted-4-thiocarbamoyl pyrazoles has been thus synthesized. The structure of the reaction products was studied using NMR spectroscopy and mass spectrometry and confirmed by X-ray diffraction analysis

Проблеми та перспективи розвитку ЖКГ в Україні: фінансовий аспект

Іртищева, І. О. Проблеми та перспективи розвитку ЖКГ в Україні: фінансовий аспект = Problems and prospects of housing and communal services development in Ukraine: financial aspects / І. О. Іртищева, М. І. Стегней, О. О. Топчій // Вісник ХНАУ. Сер. Економічні науки. – 2019. – № 2. – С. 353–365.У статті досліджено фінансовий стан підприємств ЖКГ, систематизовано основні проблеми галузі на сучасному етапі її реформування. Проведено аналіз основних джерел фінансування комунальних підприємств та ефективності бюджетних витрат на розвиток ЖКГ в Україні. Окреслено основні напрямки удосконалення механізму фінансового та інвестиційного забезпечення розвитку сфери житлово-комунальних послуг, визначено додаткові джерела та пріоритетні напрямки фінансування галузі.In the context of the transformation of the socio-economic sphere in Ukraine, the problems of effective implementation of reforms in the housing and communal services sector remain one of the most debatable and require a comprehensive strategic approach to solving them. The article investigates the financial state of utilities, systematizes the main problems of the industry at the current stage of its reform. It has been determined that the financial state of housing and communal services enterprises is unsatisfactory, which limits the ability of enterprises to modernize, restore and build housing and communal services facilities and reduces the quality of services to the population. Solving the problems of financial support for utilities requires additional analysis of their financial status and the search for additional sources of financing. The main reasons for the loss of the industry are the increase in the debt of the population for the payment of utilities and the increase in costs of enterprises due to the use of outdated systems and equipment. The analysis of the main sources of financing of public utilities and the efficiency of budget expenditures for the development of housing and communal services in Ukraine was made. It has been determined that the structure of budget expenditures for housing development is inefficient and is worsening in dynamics. Much of the state's resources are spent on financing public expenditures on housing and communal services, rather than capital investment and modernization of housing and utilities facilities and infrastructure. Due to the high level of deterioration of these objects, permanent underfunding of the industry can lead to dangerous and emergency situations, increase the level of social tension in society, and environmental degradation in cities. At the same time, the transition to market economy conditions in the sector, provided that the appropriate institutional environment is created, creates the preconditions for attracting additional sources of financing for the industry, including: private and foreign investment, loans, mutual funds and more. The solution to the problems of housing and utilities financing lies in the support the form of decentralized approaches aimed at increasing the investment attractiveness of the industry for both internal and external investors, developing forms of public-private and municipal-private partnerships, forming a network of utility banks, intensifying cooperation with international financial institutions, аattraction of funds in priority directions of housing and utilities development

Development of Sanitary-safe Poultry Paste Products with Balanced Fatty Acid and Vitamin Composition

Development of original recipes of meat pastes enriched with biologically active components due to the use of vitaminized blended vegetable oils (VBVO) and protein-fat emulsions (PFE) on their basis for general and special nutrition was considered. In the process of this work, eight recipes of chicken and Turkey meat paste were developed using PFEs which were included in the recipe in an amount of 15...20 % and two recipes with vitaminized blended vegetable oils of two-component and three-component compositions in an amount of 10 %. Samples of the pastes prepared according to DStU 4432:2005, which contained 10 % of slab bacon were taken as reference samples.A complex of organoleptic, physico-chemical, biochemical, functional-technological, structural-mechanical, sanitary-hygienic and medico-biological studies of the new meat paste recipes has been carried out. By way of mathematical modeling, yield of products with a balanced composition was optimized depending on the amount of protein-fat emulsion and vitaminized blended vegetable oil and the type of protein in minced meat. Composition of vegetable oils has been developed and their fatty acid composition and content of fat-soluble vitamins in them were determined by gas chromatographic methodModern molecular genetic methods have been applied for an accelerated diagnosis of paste safety concerning the regulated spore-forming food poisoning agents such as Clostridium perfringens and Bacillus cereus, the quantity of mesophilic aerobic and facultative anaerobic microorganisms (QMAFAnM), Coliform bacteria or Bacteria of Group of Escherichia Coli (BGEC) bacteria of intestinal stem group (BISG), sulfite-reducing clostridia, Staphylococcus aureus, L. monocytogenes and Salmonella. Shelf life of meat pastes was doubled (up 48 hours) while DStU 4432:2005 specifies 24 hours. Expediency of their introduction in production was prove