Mechanical properties and biocompatibility of the sputtered Ti doped hydroxyapatite

The hydroxyapatite enriched with Ti were prepared as possible candidates for biomedical applications especially for implantable devices that are in direct contact to the bone. The hydroxyapatites with different Ti content were prepared by RF magnetron sputtering on Ti-6Al-4V alloy using pure hydroxyapatite and TiO2 targets. The content of Ti was modified by changing the RF power fed on TiO2 target. The XPS and FTIR analyses revealed the presence of hydroxyapatite structure. The hardness and elastic modulus of the hydroxyapatite were increased by Ti addition. After 5 days of culture, the cell viability of the Ti-6Al-4V was enhanced by depositing with undoped or doped hydroxyapatite. The Ti additions led to an increase in cell viability of hydroxyapatite, after 5 days of culture. The electron microscopy showed the presence of more cells on the surface of Ti-enriched hydroxyapatite than those observed on the surface of the uncoated alloys or undoped hydroxyapatite. (C) 2016 Elsevier Ltd. All rights reserved

Effect of the deposition temperature on corrosion resistance and biocompatibility of the hydroxyapatite coatings

Hydroxyapatite (HAP) ceramics belong to a class of calcium phosphate-based materials, which have been widely used as coatings on titanium medical implants in order to improve bone fixation and thus to increase the lifetime of the implant. In this study, HAP coatings were deposited from pure HAP targets on Ti6Al4V substrates using the radio-frequency magnetron sputtering technique at substrate temperatures ranging from 400 to 800 degrees C. The surface morphology and the crystallographic structure of the films were investigated by atomic force microscopy (AFM), scanning electron microscopy (SEM) and X-ray diffraction (XRD). The corrosion resistance of the coatings in saliva solution at 37 degrees C was evaluated by potentiodynamic polarization. Additionally, the human osteosarcoma cell line (MG-63) was used to test the biocompatibility of the coatings. The results showed that all of the coatings grown uniformly and that the increasing substrate temperature induced an increase in their crystallinity. Corrosion performance of the coatings was improved with the increase of the substrate temperature from 400 degrees C to 800 degrees C. Furthermore, all the coatings support the attachment and growth of the osteosarcoma cells with regard to the in vitro test findings. (C) 2015 Elsevier B.V. All rights reserved

Mechanical, In Vitro Corrosion Resistance and Biological Compatibility of Cast and Annealed Ti25Nb10Zr Alloy

Compared to other alloys, Ti6Al4V is the most used in medicine. In recent years, concerns regarding the toxicity of Al and V elements found in the composition of Ti6Al4V have drawn the attention of the scientific community, due to the release of Al or V ions after long term exposure to human body fluids which can lead to a negative response of the human host. Based on this, the aim of the paper was to manufacture a Ti25Nb10Zr alloy consisting of biocompatible elements which can replace Ti6Al4V usage in medical applications. In order to prove that this alloy possessed improved properties, the mechanical, wear and corrosion resistance, wettability, and cell viability were performed in comparison with those of the Ti6Al4V alloy. The corrosion behavior of this new alloy in simulated body fluid (SBF) and Hank solutions is superior to that of Ti6Al4V. The cast Ti25Nb10Zr alloy has a good tribological performance in SBF, while annealed Ti25Nb10Zr alloy is better in Hank solution. Cell viability and proliferation assay after five days indicated that Ti25Nb10Zr presented a good viability and proliferation with values of approximately 7% and 10% higher, respectively, than the ones registered for pure Ti. When compared with Ti6Al4V, the obtained results for Ti25Nb10Zr indicated smaller values with 20% in the case of both tests. Overall, it can be concluded that cell proliferation and viability tests indicated that the biocompatibility of the Ti25Nb10Zr alloy is as good as pure Ti and Ti6Al4V alloy