Theoretical elements of veterinary therapeutics

The present essay describes, logically and in a synthetic way, the main elements of veterinary therapeutics. The first part refers to the concept of dose and the main factors affecting its establishment, presenting the elements related to: weight and body surface area, the therapeutic range, animal’s size, genetic factors, specific variations, digestive tract’s anatomy, factors related to age, sex, pregnancy, time of administration, tolerance and intolerance to medications, and factors that may influence response to the medication (diminished/amplified response, dose administrations’ toxicity, etc.). Following are revealed the key factors that determine the administration’s, frequency like: drug’s cleareance,drug’s concentration, administration rate, repeated-dose effect and the frequency establishing, etc. There are no missing also the elements that are describing: the plateau effect, zero-order kinetics, drug residues effect, the dose-effect relationship, the first-pass effect, latency and intensity, the risk-benefit ratio in the veterinary therapy, to full understanding of the concepts by the vet practicians

Network On Veterinary Medicines Initiated By The European Federation For Pharmaceutical Sciences

The European Federation for Pharmaceutical Sciences (EUFEPS) was founded 25 years ago by more than 20 national pharmaceutical societies and faculty members. As a pan-European organization, it brings together pharmaceutical societies as well as academic, industrial and regulatory scientists engaged in drug research and development, drug regulation and education of professionals working in these fields. EUFEPS represents pharmaceutical sciences in Europe and is recognized as such by both the European Commission and the European Medicines Agency. EUFEPS cooperates with the European Federation of Pharmaceutical Industries and other European organizations and maintains global connections with agencies such as the US Food and Drug Administration and the American Association of Pharmaceutical Scientists. EUFEPS has established specified networks forming the basis of its activities. The creation of a Network on Veterinary Medicines is prompted by the manifold problems resulting from the use of veterinary drugs and its inherent interconnections with human medicine, environmental and public health. A long-term goal of this initiative was to expand the spectrum of available therapeutics for use in animals, including the development of innovative delivery systems.Wo

The use of Thiolated Polymers a Carrier Matrix in Oral Pepide Delivery-Proof of Concept

It was the aim of this study to develop an oral delivery system for the peptide drug antide. The stability of the therapeutic peptide towards gastrointestinal peptidases was evaluated. The therapeutic agent and the permeation mediator glutathione were embedded in the thiolated polymer chitosan-4-thio-butylamidine conjugate (chitosan-TBA conjugate) and compressed to tablets. Drug release studies were performed in the dissolution test apparatus according to the Pharmacopoeia Europea using the paddle method and demineralized water as release medium. In order to avoid mucoadhesion of these delivery systems already in the oral cavity and oesophagus tablets were coated with a triglyceride. These tablets were orally given to pigs (weight: 50 ± 2 kg; Edelschwein Pietrain). Moreover, antide was administered intravenously, subcutaneously and orally in solution. Results showed stability of antide towards pepsin, trypsin and chymotrypsin. In contrast, antide was rapidly degraded by elastase. Consequently a stomach-targeted delivery system was designed. Drug release studies demonstrated an almost zero-order controlled release of antide over 8 h. In vivo studies demonstrated a relative bioavailability of 34.4% for the subcutaneous administration. Oral administration of antide in solution led to no detectable concentrations of the drug in plasma at all. In contrast, administering antide being incorporated in the thiolated polymer resulted in a significant uptake of the peptide. The absolute and relative bioavailability was determined to be 1.1% and 3.2%, respectively

Network on veterinary medicines initiated by the European Federation For Pharmaceutical Sciences

The European Federation for Pharmaceutical Sciences (EUFEPS) was founded 25 years ago by more than 20 national pharmaceutical societies and faculty members. As a pan- European organisation it brings together pharmaceutical societies as well as academic, industrial, and regulatory scientists engaged in drug research and development, drug regulation, and education of professionals working in these fields. EUFEPS represents pharmaceutical sciences in Europe and is recognised as such by both the European Commission and the European Medicines Agency. EUFEPS cooperates with the European Federation of Pharmaceutical Industries and other European organisations and maintains global connections with agencies such as the US Food and Drug Administration and the American Association of Pharmaceutical Scientists. EUFEPS has established specified networks forming the basis of its activities. The creation of a Network on Veterinary Medicines is prompted by the manifold problems resulting from the use of veterinary drugs and its inherent interconnections with human medicine, environmental and public health. A long-term goal of this initiative is to expand the spectrum of available therapeutics for use in animals, including the development of innovative delivery systems.This is the peer reviewed version of the following article: Mochel, J. P., E. Tyden, K. Hellmann, J. C. Vendrig, S. Şenel, L. Dencker, R. T. Cristina, H. Linden, and I. Schmerold. "Network on veterinary medicines initiated by the European Federation For Pharmaceutical Sciences." Journal of veterinary pharmacology and therapeutics (2017), which has been published in final form at doi: 10.1111/jvp.12472. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.</p

Relationship between levels of oxidative DNA damage, lipid peroxidation and mitochondrial membrane potential in young and old F344 rats

10.1080/10715760600556074Free Radical Research404393-40