Evaluation of resampling applied to UAV imagery for weed detection using OBIA

Los vehículos aéreos no tripulados (UAVs) son una tecnología emergente en el estudio de parámetros agrícolas por sus características y por portar sensores en diferente rango espectral. En este trabajo se ha detectado y cartografiado rodales de malas hierbas en fase temprana mediante análisis OBIA para elaborar mapas que optimicen el tratamiento herbicida localizado. Se ha aplicado resampling (resampleo) sobre imágenes tomadas en campo desde un UAV (UAV-I) para crear una nueva imagen con distinta resolución espacial. A las imágenes resampleadas (RS-I) se les evaluó la calidad espacial y espectral y la eficacia de nuestro análisis en la detección de malas hierbas. Los resultados de las imágenes RS-I muestran una precisión similar a las imágenes UAV-I siendo factible su utilización en tecnologías de manejo localizado de malas hierbas. Se discuten las ventajas del uso de la técnica de resampling en imágenes UAV.Unmanned aerial vehicles (UAV) are an emerging technology for the study of agriculture parameters due to its characteristics and the availability of embedding sensors with different spectral range. In our study, the detection and mapping of weeds in early phenological stage allowed to design a strategy for the optimizing of herbicide treatment. In this work, resampling is used to create a new version of an image with a different spatial resolution, using real UAV imagery. A spatial and spectral quality evaluation was carried out to resampled images (RS-I), and then, our workflow for weed detection applied. The results showed that RS-I and UAV-I showed similar accuracy on weed detection and thus could be used for site-specific weed management achieving a percentage of savings in the herbicide. Opportunities of using RS-I are discussed

Diagnòstic i seguiment farmacoterapèutic de la hiperuricèmia i gota

Treballs d'Educació Farmacèutica als ciutadans. Unitat Docent d'Estades en Pràctiques Tutelades. Facultat de Farmàcia, Universitat de Barcelona. Curs: 2016-2017. Tutors: Anna Mas Comas i Ramón Jódar Masanés i Marian March Pujol.L’objectiu principal d’aquest treball és la cerca bibliogràfica de les diferents inquietuds que pot tenir un pacient amb hiperuricèmia o gota. Més concretament queden resumits en els següents punts: 1. Estudiar els diferents efectes de tenir una alta concentració plasmàtica d’àcid úric, quines són les causes i la prevalença dins de la població occidental general. 2. Analitzar les manifestacions clíniques associades així com el seu diagnòstic. 3. Determinar com afecten les mesures no farmacològiques i farmacològiques en el maneig de la patologia. 4. Reforçar el paper del farmacèutic en el maneig de la malalti

Predicting the onset and persistence of episodes of depression in primary health care. The predictD-Spain study: Methodology

Background: The effects of putative risk factors on the onset and/or persistence of depression remain unclear. We aim to develop comprehensive models to predict the onset and persistence of episodes of depression in primary care. Here we explain the general methodology of the predictD-Spain study and evaluate the reliability of the questionnaires used. Methods: This is a prospective cohort study. A systematic random sample of general practice attendees aged 18 to 75 has been recruited in seven Spanish provinces. Depression is being measured with the CIDI at baseline, and at 6, 12, 24 and 36 months. A set of individual, environmental, genetic, professional and organizational risk factors are to be assessed at each follow-up point. In a separate reliability study, a proportional random sample of 401 participants completed the test-retest (251 researcher-administered and 150 self-administered) between October 2005 and February 2006. We have also checked 118,398 items for data entry from a random sample of 480 patients stratified by province. Results: All items and questionnaires had good test-retest reliability for both methods of administration, except for the use of recreational drugs over the previous six months. Cronbach's alphas were good and their factorial analyses coherent for the three scales evaluated (social support from family and friends, dissatisfaction with paid work, and dissatisfaction with unpaid work). There were 191 (0.16%) data entry errors. Conclusion: The items and questionnaires were reliable and data quality control was excellent. When we eventually obtain our risk index for the onset and persistence of depression, we will be able to determine the individual risk of each patient evaluated in primary health car

Doping of graphene nanoribbons via functional group edge modification

We report the on-surface synthesis of 7-armchair graphene nanoribbons (7-AGNRs) substituted with nitrile (CN) functional groups. The CN groups are attached to the GNR backbone by modifying the 7-AGNR precursor. Whereas many of these groups survive the on-surface synthesis, the reaction process causes the cleavage of some CN from the ribbon backbone and the on-surface cycloisomerization of few nitriles onto pyridine rings. Scanning tunneling spectroscopy and density functional theory reveal that CN groups behave as very efficient n-dopants, significantly downshifting the bands of the ribbon and introducing deep impurity levels associated with the nitrogen electron lone pairs.This work was supported by FP7 FET-ICT “Planar Atomic and Molecular Scale devices” (PAMS) project (funded by the European Commission under Contract No. 610446), by the Agencia Estatal de Investigacion (Cooperative Grant No. MAT2016-78293 and Grant FIS2015-62538-ERC), the Basque Government (Dep. de Educacion and UPV/EHU, Grant No. IT-756-13, and Dep. Industry, Grant PI_2015_1_42), the Xunta de Galicia (Centro singular de investigacion de Galicia accreditation 2016−2019, ED431G/09), and the European Regional Development Fund (ERDF).Peer Reviewe

Electronic consequences of chemical doping of 7-Armchair Graphene Nanoribbons

Resumen del trabajo presentado a la International Conference on Nanoscience + Technology (ICN+T), celebrada en Brno (Czech Republic) del 22 al 27 de julio de 2018.The tunable electronic structure of Graphene Nanoribbons (GNRs) with different edge types has provoked great interest due to potential applications in electronic devices as molecular diodes or transistors. Thanks to the on-surface synthesis of chemically customized molecular precursors, nanoribbons with atomically defined structure can be grown. This high precision in their bottom-up growth allows to tune their electronic structure via width control or chemical doping. Here we use two different strategies to chemically modify 7-armchair GNRs (7-AGNRs) to clarify how the chemical modifications on the nanoribbons’ structure affect their electronic properties. By means of Scanning Tunneling Spectroscopy we tackle with atomic precision this issue on 7-AGNRs with substitutional nitrile functional groups at the ribbons’ edges and on 7-AGNRs with substitutional boron atoms within the ribbons’ backbone. We find that in the first case the CN groups lead to an efficient n-like doping of the ribbon, while in the second case B atoms induce the formation of a new acceptor band and bandgap renormalization.Peer Reviewe

Quantitative trait loci for fatness at growing and reproductive stages in Iberian × Meishan F2 sows

A considerable number of fatness QTL have been identified in growing pigs, but there is a lack of knowledge about the genetic architecture of this trait in gilts and sows. We have performed a genome scan, in 255 Iberian × Meishan F2 sows, for backfat thickness (BF) at 150 (BF150) and 210 (BF210) days of age, 30 days after conception (BF30) and 7–10 days before farrowing (BFbf). We have found one BF150 QTL in SSC6 (120 cM) that was highly significant (P < 0.001) at the chromosome-wide level and suggestive at the genome-wide level (P < 0.1). Ten additional chromosome-wide significant QTL were found for sow BF150 (SSC1, SSC13), BF210 (SSC6, SSC8, SSC15), BF30 (SSC5, SSC6) and BFbf (SSC1, SSC6, SSC13). The location of several of the BF QTL varied depending on the growing and reproductive status of the sow, suggesting that part of these genetic effects may have a temporal pattern of phenotypic expression.Financial support was provided by Ministerio de Educación y Ciencia, Spain (Grant AGL2004-08368-C03/GAN).Peer reviewe

An optimized MNK1b aptamer, apMNKQ2, and its potential use as a therapeutic agent in breast cancer

16 pags., 8 figs.Breast cancer is the most commonly diagnosed and leading cause of cancer death among women worldwide. Mitogen-activated protein kinase-interacting kinases (MNKs) promote the expression of several oncogenic proteins and are overexpressed in several types of cancer. In human cells, there are four isoforms of MNKs. The truncated isoform MNK1b, first described in our laboratory, has a higher basal activity and is constitutively active. Aptamers are emerging in recent years as potential therapeutic agents that show significant advantages over drugs of other nature. We have previously obtained and characterized a highly specific aptamer against MNK1b, named apMNK2F, with a dissociation constant in the nanomolar range, which produces significant inhibition of proliferation, migration, and colony formation in breast cancer cells. Furthermore, its sequence analysis predicted two G-quadruplex structures. In this work, we show the optimization process of the aptamer to reduce its size, improving its stability. The obtained aptamer, named apMNKQ2, is able to inhibit proliferation, colony formation, migration, and invasion in breast cancer cells. In murine models of breast cancer, apMNKQ2 has demonstrated its efficacy in reducing tumor volume and the number of metastases. In conclusion, apMNKQ2 could be used as an anti-tumor drug in the future.C.P.-D. was supported by grant RTC-2014-1986-1 from the Ministry of Economy and Competitiveness (Spain). R.F.-M... by predoctoral contract (PEJD-2018-BMD-4416) from the Community of Madrid (Spain) and FPU19/02929 from the Ministry of Science, Innovation and Universities (Spain). R.C.-B. for predoctoral contracts (PEJD 2016-BMD-2145 and 2018-BMD-9201) from the Community of Madrid and grant RTC2019-07227-1. M. EM., and V.M.G. are researchers at FIBio-HRC. Supported by grants RTC2019-07227-1, PID2020-116620GB-T.I.00, and PID2019-105417RB-I00, funded by MCIN/ AEI /10.13039/501100011033 (Ministry of Economy and Competitiveness, Spain).Peer reviewe

Relationship between olive oil consumption and ankle-brachial pressure index in a population at high cardiovascular risk

Background and aims: The aim of this study was to ascertain the association between the consumption of different categories of edible olive oils (virgin olive oils and olive oil) and olive pomace oil and ankle-brachial pressure index (ABI) in participants in the PREDIMED-Plus study, a trial of lifestyle modification for weight and cardiovascular event reduction in individuals with overweight/obesity harboring the metabolic syndrome. Methods: We performed a cross-sectional analysis of the PREDIMED-Plus trial. Consumption of any category of olive oil and olive pomace oil was assessed through a validated food-frequency questionnaire. Multivariable linear regression models were fitted to assess associations between olive oil consumption and ABI. Additionally, ABI ≤1 was considered as the outcome in logistic models with different categories of olive oil and olive pomace oil as exposure. Results: Among 4330 participants, the highest quintile of total olive oil consumption (sum of all categories of olive oil and olive pomace oil) was associated with higher mean values of ABI (beta coefficient: 0.014, 95% confidence interval [CI]: 0.002, 0.027) (p for trend = 0.010). Logistic models comparing the consumption of different categories of olive oils, olive pomace oil and ABI ≤1 values revealed an inverse association between virgin olive oils consumption and the likelihood of a low ABI (odds ratio [OR] 0.73, 95% CI [0.56, 0.97]), while consumption of olive pomace oil was positively associated with a low ABI (OR 1.22 95% CI [1.00, 1.48]). Conclusions: In a Mediterranean population at high cardiovascular risk, total olive oil consumption was associated with a higher mean ABI. These results suggest that olive oil consumption may be beneficial for peripheral artery disease prevention, but longitudinal studies are needed

Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk

Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids and different cardiometabolic risk factors and the plasma fatty acid profile. This is a cross-sectional evaluation of baseline data conducted in a subcohort (106 women and 124 men) of an ongoing multi-factorial lifestyle trial for primary cardiovascular prevention. Plasma concentrations of carotenoids were quantified by liquid chromatography coupled to mass spectrometry. The associations between carotenoid concentrations and cardiometabolic risk factors were assessed using regression models adapted for interval-censored variables. Carotenoid concentrations were cross-sectionally inversely associated with serum triglyceride concentrations [-2.79 mg/dl (95% CI: -4.25, -1.34) and -5.15 mg/dl (95% CI: -7.38, -2.93), p-values = 0.0002 and <0.00001 in women and men, respectively], lower levels of plasma saturated fatty acids [-0.09% (95% CI: -0.14, -0.03) and -0.15 % (95% CI: -0.23, -0.08), p-values = 0.001 and 0.0001 in women and men, respectively], and higher levels of plasma polyunsaturated fatty acids [(0.12 % (95% CI: -0.01, 0.25) and 0.39 % (95% CI: 0.19, 0.59), p-values = 0.065 and 0.0001 in women and men, respectively] in the whole population. Plasma carotenoid concentrations were also associated with higher plasma HDL-cholesterol in women [0.47 mg/dl (95% CI: 0.23, 0.72), p-value: 0.0002], and lower fasting plasma glucose in men [-1.35 mg/dl (95% CI: -2.12, -0.59), p-value: 0.001]. Keywords: Mediterranean diet; PREDIMED-plus study; cardiovascular health; liquid chromatography; mass spectrometry; plasma carotenoids