Project goals, target selection, and stellar characterization

The detection of habitable worlds is one of humanitya-s greatest endeavors. Thus far, astrobiological studies have shown that one of the most critical components for allowing life to develop is liquid water. Its chemical properties and its capacity to dissolve and, hence, transport other substances makes this constituent a key piece in this regard. As a consequence, looking for life as we know it is directly related to the search for liquid water. For a remote detection of life in distant planetary systems, this essentially means looking for planets in the so-called habitable zone. In this sense, K-dwarf stars are the perfect hosts to search for planets in this range of distances. Contrary to G-dwarfs, the habitable zone is closer, thus making planet detection easier using transit or radial velocity techniques. Contrary to M-dwarfs, stellar activity is on a much smaller scale, hence, it has a smaller impact in terms of both the detectability and the true habitability of the planet. Also, K-dwarfs are the quietest in terms of oscillations, and granulation noise. In spite of this, there is a dearth of planets in the habitable zone of K-dwarfs due to a lack of observing programs devoted to this parameter space. In response to a call for legacy programs of the Calar Alto observatory, we have initiated the first dedicated and systematic search for habitable planets around these stars: K-dwarfs Orbited By habitable Exoplanets (KOBE). This survey is monitoring the radial velocity of 50 carefully pre-selected K-dwarfs with the CARMENES instrument over five semesters, with an average of 90 data points per target. Based on planet occurrence rates convolved with our detectability limits, we expect to find 1.68 ± 0.25 planets per star in the KOBE sample. Furthermore, in half of the sample, we expect to find one of those planets within the habitable zone. Here, we describe the motivations, goals, and target selection for the project as well as the preliminary stellar characterization. © 2022 EDP Sciences. All rights reserved

A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma

<p>Abstract</p> <p>Background</p> <p>Osteosarcoma (OS) is a bone malignancy which occurs primarily in adolescents. Since it occurs during a period of rapid growth, genes important in bone formation and growth are plausible modifiers of risk. Genes involved in DNA repair and ribosomal function may contribute to OS pathogenesis, because they maintain the integrity of critical cellular processes. We evaluated these hypotheses in an OS association study of genes from growth/hormone, bone formation, DNA repair, and ribosomal pathways.</p> <p>Methods</p> <p>We evaluated 4836 tag-SNPs across 255 candidate genes in 96 OS cases and 1426 controls. Logistic regression models were used to estimate the odds ratios (OR) and 95% confidence intervals (CI).</p> <p>Results</p> <p>Twelve SNPs in growth or DNA repair genes were significantly associated with OS after Bonferroni correction. Four SNPs in the DNA repair gene <it>FANCM </it>(ORs 1.9-2.0, <it>P </it>= 0.003-0.004) and 2 SNPs downstream of the growth hormone gene <it>GH1 </it>(OR 1.6, <it>P </it>= 0.002; OR 0.5, <it>P </it>= 0.0009) were significantly associated with OS. One SNP in the region of each of the following genes was significant: <it>MDM2</it>, <it>MPG</it>, <it>FGF2</it>, <it>FGFR3</it>, <it>GNRH2</it>, and <it>IGF1</it>.</p> <p>Conclusions</p> <p>Our results suggest that several SNPs in biologically plausible pathways are associated with OS. Larger studies are required to confirm our findings.</p

Management of peripheral facial nerve palsy

Peripheral facial nerve palsy (FNP) may (secondary FNP) or may not have a detectable cause (Bell’s palsy). Three quarters of peripheral FNP are primary and one quarter secondary. The most prevalent causes of secondary FNP are systemic viral infections, trauma, surgery, diabetes, local infections, tumor, immunological disorders, or drugs. The diagnosis of FNP relies upon the presence of typical symptoms and signs, blood chemical investigations, cerebro-spinal-fluid-investigations, X-ray of the scull and mastoid, cerebral MRI, or nerve conduction studies. Bell’s palsy may be diagnosed after exclusion of all secondary causes, but causes of secondary FNP and Bell’s palsy may coexist. Treatment of secondary FNP is based on the therapy of the underlying disorder. Treatment of Bell’s palsy is controversial due to the lack of large, randomized, controlled, prospective studies. There are indications that steroids or antiviral agents are beneficial but also studies, which show no beneficial effect. Additional measures include eye protection, physiotherapy, acupuncture, botulinum toxin, or possibly surgery. Prognosis of Bell’s palsy is fair with complete recovery in about 80% of the cases, 15% experience some kind of permanent nerve damage and 5% remain with severe sequelae

Pediatric DXA: clinical applications

Normal bone mineral accrual requires adequate dietary intake of calcium, vitamin D and other nutrients; hepatic and renal activation of vitamin D; normal hormone levels (thyroid, parathyroid, reproductive and growth hormones); and neuromuscular functioning with sufficient stress upon the skeleton to induce bone deposition. The presence of genetic or acquired diseases and the therapies that are used to treat them can also impact bone health. Since the introduction of clinical DXA in pediatrics in the early 1990s, there has been considerable investigation into the causes of low bone mineral density (BMD) in children. Pediatricians have also become aware of the role adequate bone mass accrual in childhood has in preventing osteoporotic fractures in late adulthood. Additionally, the availability of medications to improve BMD has increased with the development of bisphosphonates. These factors have led to the increased utilization of DXA in pediatrics. This review summarizes much of the previous research regarding BMD in children and is meant to assist radiologists and clinicians with DXA utilization and interpretation

Regaining In-Group Continuity in Times of Anxiety about the Group's Future : A Study on the Role of Collective Nostalgia Across 27 Countries

Collective nostalgia for the good old days of the country thrives across the world. However, little is known about the social psychological dynamics of this collective emotion across cultures. We predicted that collective nostalgia is triggered by collective angst as it helps people to restore a sense of in-group continuity via stronger in-group belonging and out-group rejection (in the form of opposition to immigrants). Based on a sample (N = 5,956) of individuals across 27 countries, the general pattern of results revealed that collective angst predicts collective nostalgia, which subsequently relates to stronger feelings of in-group continuity via in-group belonging (but not via out-group rejection). Collective nostalgia generally predicted opposition to immigrants, but this was subsequently not related to in-group continuity. © 2018 Hogrefe Publishing.Peer reviewe

Effect of nitrogen fertilization management on mineral nitrogen content in soil and winter wheat productivity

ArticleIn recent years farmers must use integrated crop growing principles. One of the most important principle isto balance usage of mineral elementsin crop cultivation, especially nitrogen management. Excessive and unbalanced usage of nitrogen fertilizer reduces nitrogen use efficiency and increases nitrate leaching in surface and groundwater. The dynamics of nitrogen forms in soil at different depths and different plant growth stages are studied to increase the productivity of winter wheat, promoting nitrogen uptake in plants and reducing nitrogen leaching during the vegetation period. Field experiments were carried out at the Research and Training Farm Vecauce of the Latvia University of Life Science and Technologies from 2012 till 2015. Researched factors were nitrogen (N) fertilizer rate: 0 – control, 85, 153, 187, and N rate determined by chlorophylmeter (Yara N-tester) 180 (2012/2013), 150 (2013/2014), 205 (2014/2015) N kg ha-1 , nitrogen and sulphur (S) fertilizer rate – N175+S21 kg ha-1 , and conditions of the growing seasons: 2012/2013, 2013/2014 and 2014/2015. The content of nitrate (NO3–N) nitrogen and ammonium (NH4–N) nitrogen was determined in the soil layers 0–20 cm, 20–40 cm and 40–60 cm at the growth stages (GS) 30–32, 49–51, 69 and 90–92. All trial years the amount of nitrate nitrogen and ammonium nitrogen in soil decreased during vegetation, but increased with increasing fertilization dose. Nitrate nitrogen content was significantly influenced by year in 0–40 cm soil layer (P < 0.01) and by nitrogen fertilizer in the 20–40 cm soil layer. Ammonium nitrogen content had significant influence only on nitrogen fertilizer at 20–40 cm soil layer (P < 0.05). Average grain yields did not show significant correlation with the nitrate nitrogen and ammonium nitrogen in different soil layers and plant growth stages, except nitrate nitrogen content in soil layer 40–60 cm at GS 30–32 and ammonium nitrogen content in soil layer 40–60 cm at GS 69 and GS 90–92