Versioning Vocabularies in a Linked Data World

Submitted for and presented to the IFLA 2014 satellite meeting on Linked Open Data in Paris, France, August, 2014.Policies regarding change management in open or public vocabularies used in the context of Linked Open Data have lagged behind those driving other web-based communities of practice. A fresh emphasis on vocabulary management and maintenance has begun to emerge, as the reliance on potentially volatile vocabularies, and the implications of their ongoing growth and change, has begun to permeate the conversation. Particularly in libraries, where management of commonly used vocabularies has long been a community-wide activity, management of vocabularies has been seen as the realm of larger institutions and organizations. This centralized control has been workable (if slow to evolve to incorporate new needs) so long as data distribution has also been centralized, but this pattern of distribution has become more questionable as a transition to the more open world of linked data begins to demonstrate the inflexibility of traditional practices. As more attention shifts to new vocabulary standards and usages outside libraries, researchers and innovative organizations have sought to take advantage of this boom in interest, but unlike librarians, they have little experience in implementation over time. Merging the technology of the Semantic Web with the information management experience of libraries seems a reasonable strategy, but better understanding by all of where practices must change is critical

Orchestrating Metadata Enhancement Services: Introducing Lenny

Harvested metadata often suffers from uneven quality to the point that utility is compromised. Although some aggregators have developed methods for evaluating and repairing specific metadata problems, it has been unclear how these methods might be scaled into services that can be used within an automated production environment. The National Science Digital Library (NSDL), as part of its work with INFOMINE, has developed a model of ser-vice interaction that enables loosely-coupled third party services to provide metadata enhancements to a central repository, with interactions orchestrated by a centralized software application

Geogenomic segregation and temporal trends of human pathogenic Escherichia coli o157:H7, Washington, USA, 2005-2014

The often-noted and persistent increased incidence of Escherichia coli O157:H7 infections in rural areas is not well understood. We used a cohort of E. coli O157:H7 cases reported in Washington, USA, during 2005–2014, along with phylogenomic characterization of the infecting isolates, to identify geographic segregation of and temporal trends in specific phylogenetic lineages of E. coli O157:H7. Kernel estimation and generalized additive models demonstrated that pathogen lineages were spatially segregated during the period of analysis and identified a focus of segregation spanning multiple, predominantly rural, counties for each of the main clinical lineages, Ib, IIa, and IIb. These results suggest the existence of local reservoirs from which humans are infected. We also noted a secular increase in the proportion of lineage IIa and IIb isolates. Spatial segregation by phylogenetic lineage offers the potential to identify local reservoirs and intervene to prevent continued transmission

A Metadata Registry from Vocabularies Up: the NSDL Registry Project

The NSDL Metadata Registry is designed to provide humans and machines with the means to discover, create, access and manage metadata schemes, schemas, application profiles, crosswalks and concept mappings. This paper describes the general goals and architecture of the NSDL Metadata Registry as well as issues encountered during the first year of the project's implementation.This material is based upon work supported by the National Science Foundation under Grant No. DUE-0532828

A demonstration of athermal effects of continuous microwave irradiation on the growth and antibiotic sensitivity of Pseudomonas aeruginosa PAO1.

Stress, caused by exposure to microwaves (2.45GHz) at constant temperature (37± 0.5(o) C), alters the growth profile of Pseudomonas aeruginosa PAO1. In the absence of microwave treatment a simple, highly reproducible growth curve was observed over 24 hours or more. Microwave treatment caused no reduction in growth during the first 6 hours, but at a later stage (>12hours) the growth was markedly different to the controls. Secondary growth, typical of the presence of persisters clearly became apparent, as judged by both the dissolved oxygen and the cell density profiles. These treated cells showed distinct morphological changes, but on re-growth these cells reverted to normal. The Microwave Induced Persisters were subject to antibiotic challenge (tobramycin) and showed increased sensitivity when compared to the un-stressed planktonic cells. This is in marked contrast to antibiotic induced persisters which show increased resistance. This provides evidence for both a non-thermal effect of microwaves and a previously undescribed route to a novel form of antibiotic susceptible persister cells. This article is protected by copyright. All rights reserved

The effect of self-focusing on laser space-debris cleaning

A ground-based laser system for space-debris cleaning will use powerful laser pulses that can self-focus while propagating through the atmosphere. We demonstrate that for the relevant laser parameters, this self-focusing can noticeably decrease the laser intensity on the target. We show that the detrimental effect can be, to a great extent, compensated for by applying the optimal initial beam defocusing. The effect of laser elevation on the system performance is discussed

Sleep Apnoea Adverse Effects on Cancer: True, False, or Too Many Confounders?

: Obstructive sleep apnoea (OSA) is a prevalent disorder associated with increased cardiovascular, metabolic and neurocognitive morbidity. Recently, an increasing number of basic, clinical and epidemiological reports have suggested that OSA may also increase the risk of cancer, and adversely impact cancer progression and outcomes. This hypothesis is convincingly supported by biological evidence linking certain solid tumours and hypoxia, as well as by experimental studies involving cell and animal models testing the effects of intermittent hypoxia and sleep fragmentation that characterize OSA. However, the clinical and epidemiological studies do not conclusively confirm that OSA adversely affects cancer, even if they hold true for specific cancers such as melanoma. It is likely that the inconclusive studies reflect that they were not specifically designed to test the hypothesis or because of the heterogeneity of the relationship of OSA with different cancer types or even sub-types. This review critically focusses on the extant basic, clinical, and epidemiological evidence while formulating proposed directions on how the field may move forward