Stroboscopic Laser Diagnostics for Detection of Ordering in One-Dimensional Ion beam

A novel diagnostic method for detecting ordering in one-dimensional ion beams is presented. The ions are excited by a pulsed laser at two different positions along the beam and fluorescence is observed by a group of four photomultipliers. Correlation in fluorescence signals is firm indication that the ion beam has an ordered structure.Comment: 7 pages, REVTEX, fig3 uuencoded, figs 1-2 available upon request from [email protected], to appear in Phys. Rev.

Mentorship in Radiography: an Indispensable Tool for Sustainable Healthcare Transformation

  Background: The concept of mentorship has gained widespread popularity in literature across different walks of life owing to the significant benefits attached to it. Purpose: This paper intends to discuss the need for mentorship in radiography, as an indispensable tool for a sustainable healthcare transformation, taking clues from other health science disciplines and medicine. Method: Authors reviewed relevant literature on the subject to have an in-depth and updated knowledge both in the health sciences as well as in other disciplines. Search engines such as Google Scholar, My Websearch, and data base such as Science Direct, Hinari, Taylor and Francis and Medknow were consulted. Several articles that discussed mentorship across various disciplines were reviewed. Those with ideas and concepts that fit into the purpose of the study were included. Results: Several definitions and types of mentorship exist across different walks of life based on literature. However, we decided to adopt the definition of mentorship and types of mentorship by Feldman, who defined mentorship as a dynamic, reciprocal relationship in a work environment between an advanced career incumbent and a beginner, aimed at promoting the development of both. The uniform agreement across various disciplines is that mentoring is a crucial component of success. However, its application in radiography is inadequate. Conclusion: In view of the apparent benefits accruable to mentorship globally, stakeholders in radiography should make mentorship a priority, if we must maintain our role in a sustainable healthcare transformation.             &nbsp

The Practice of Universal Precautions against Body Fluid Borne Infection among Radiology Staff in Some Teaching Hospital in Northern Nigeria

Title: The Practice of Universal Precautions against Body Fluid Borne Infections among Radiology Staff in Some Teaching Hospital in Northern Nigeria. Objectives; The aim of this study was to evaluate the knowledge and practice of universal precaution against fluid borne infections among radiology staff in northern Nigeria teaching hospitals to elicit responses to questions regarding their knowledge and practice of universal precaution. Methods: A prospective cross sectional study using structured questionnaire was conducted among radiology staff practicing in teaching hospitals in northern Nigeria. The questionnaire was sent out by post and the response rate over a period of two months period was 52.5%, (n=63).  Descriptive statistics such as mean, frequency and percentages were generated using statistical package for social sciences (spss) version 14.0. Result; Results show that 95.3%, (60) of the radiology staff come in contact with body fluid in their work while 87.3%, (55) have good knowledge of universal precaution. There were 72.7%, (46) of the studied staff who practice universal precaution. Only 41.3%, (26) of the staff use the incident reporting system when exposed to patients body fluid. It also found managements laxity in providing all necessary personal protective equipment such as gloves, mask, goggles, and aprons. Conclusion: This study found radiology staff of teaching hospitals in northern Nigeria have satisfactory knowledge of universal precaution which is not matched by practice. Keywords:Universal Precautions, Fluid-borne Infection, practice, Radiology, Knowledg

A Survey of Structural Design of Diagnostic X-ray Imaging Facilities and Compliance to Shielding Design Goals in a Limited Resource Setting

Purpose: To survey structural designs of x-ray rooms and compliance to shielding design goals of three x-ray imaging facilities. Methods and Materials: The survey was conducted in three radiodiagnostic centers in South East Nigeria, labeled X, Y and Z for anonymity. A stretchable non-elastic meter rule was used to measure x-ray room dimensions. A Vernier caliper was used to measure lead thickness while a calibrated digital survey meter Radalert 100x was used for radiation survey of controlled and uncontrolled areas. Simple statistical tools such as mean and standard deviation were used for analysis with the aid of Microsoft Excel version 2007. Results: Center X had a room dimension of 2.4 m × 2.1 m, Center Y had an x-ray room dimension of 3.6 m × 3.3 m, and Center Z had two x-ray rooms with identical dimensions of 6.3 m × 3.6 m. Measured exit radiation doses for controlled areas in all the centers were: 0.00152 mSv/wk; 0.00496 mSv/wk; 0.00168 mSv/wk; 0.00224 mSv/wk respectively. Lead was the common shielding material used. Conclusion: Based on the parameters studied, Center Z had the ideal room size and layout. Relative distances from the x-ray tubes to the nearest walls were not optimized in all the centers except in Center Z. Measured exit doses were within recommended limits except in Center Y. The location of the control consoles and measured doses were appropriate and within recommended design goals

OMA orthology in 2021: website overhaul, conserved isoforms, ancestral gene order and more.

OMA is an established resource to elucidate evolutionary relationships among genes from currently 2326 genomes covering all domains of life. OMA provides pairwise and groupwise orthologs, functional annotations, local and global gene order conservation (synteny) information, among many other functions. This update paper describes the reorganisation of the database into gene-, group- and genome-centric pages. Other new and improved features are detailed, such as reporting of the evolutionarily best conserved isoforms of alternatively spliced genes, the inferred local order of ancestral genes, phylogenetic profiling, better cross-references, fast genome mapping, semantic data sharing via RDF, as well as a special coronavirus OMA with 119 viruses from the Nidovirales order, including SARS-CoV-2, the agent of the COVID-19 pandemic. We conclude with improvements to the documentation of the resource through primers, tutorials and short videos. OMA is accessible at https://omabrowser.org

OMA orthology in 2021: website overhaul, conserved isoforms, ancestral gene order and more

OMA is an established resource to elucidate evolutionary relationships among genes from currently 2326 genomes covering all domains of life. OMA provides pairwise and groupwise orthologs, functional annotations, local and global gene order conservation (synteny) information, among many other functions. This update paper describes the reorganisation of the database into gene-, group- and genome-centric pages. Other new and improved features are detailed, such as reporting of the evolutionarily best conserved isoforms of alternatively spliced genes, the inferred local order of ancestral genes, phylogenetic profiling, better cross-references, fast genome mapping, semantic data sharing via RDF, as well as a special coronavirus OMA with 119 viruses from the Nidovirales order, including SARS-CoV-2, the agent of the COVID-19 pandemic. We conclude with improvements to the documentation of the resource through primers, tutorials and short videos. OMA is accessible at https://omabrowser.org

NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival

Transcription factor NRF2 is an important regulator of oxidative stress. It is involved in cancer progression, and has abnormal constitutive expression in acute myeloid leukaemia (AML). Posttranscriptional regulation by microRNAs (miRNAs) can affect the malignant phenotype of AML cells. In this study, we identified and characterised NRF2-regulated miRNAs in AML. An miRNA array identified miRNA expression level changes in response to NRF2 knockdown in AML cells. Further analysis of miRNAs concomitantly regulated by knockdown of the NRF2 inhibitor KEAP1 revealed the major candidate NRF2-mediated miRNAs in AML. We identified miR-125B to be upregulated and miR-29B to be downregulated by NRF2 in AML. Subsequent bioinformatic analysis identified putative NRF2 binding sites upstream of the miR-125B1 coding region and downstream of the mir-29B1 coding region. Chromatin immunoprecipitation analyses showed that NRF2 binds to these antioxidant response elements (AREs) located in the 5′ untranslated regions of miR-125B and miR-29B. Finally, primary AML samples transfected with anti-miR-125B antagomiR or miR-29B mimic showed increased cell death responsiveness either alone or co-treated with standard AML chemotherapy. In summary, we find that NRF2 regulation of miR-125B and miR-29B acts to promote leukaemic cell survival, and their manipulation enhances AML responsiveness towards cytotoxic chemotherapeutics

TIPS MEMILIH DAN MENYIMPAN TELUR YANG AMAN UNTUK DIKONSUSMI

Eggs are perfect foodstuffs because they contain nutrients such as protein, fat, vitamins, and minerals in sufficient quantities. Under certain conditions, the complete nutritional content in eggs can be a good growth medium for microorganisms. It is important to educate the community about how to differentiate egg quality and how to store eggs properly so that people can choose and get eggs of good quality in the long term. The benefit is that they can be more careful in choosing the eggs to buy, and know-how to store eggs properly so that the egg's shelf life can last longer. This education was carried out online during the Covid-19 pandemic Work From Home (WFH) period using the Zoom meet application. The participants in this counseling consisted of housewives and students

Improved and standardized method for assessing years lived with disability after burns and its application to estimate the non-fatal burden of disease of burn injuries in Australia, New Zealand and the Netherlands

Background: Burden of disease estimates are an important resource in public health. Currently, robust estimates are not available for the burn population. Our objectives are to adapt a refined methodology (INTEGRIS method) to burns and to apply this new INTEGRIS-burns method to estimate, and compare, the burden of disease of burn injuries in Australia, New Zealand and the Netherlands. Methods: Existing European and Western-Australian health-related quality of life (HRQL) datasets were combined to derive disability weights for three homogenous burn injury groups based on percentage total body surface area (%TBSA) burned. Subsequently, incidence data from Australia, New Zealand, and the Netherlands from 2010 to 2017 were used to compute annual non-fatal burden of disease estimates for each of these three countries. Non-fatal burden of disease was measured by years lived w