7,229 research outputs found
Periodically driven stochastic un- and refolding transitions of biopolymers
Mechanical single molecule experiments probe the energy profile of
biomolecules. We show that in the case of a profile with two minima (like
folded/unfolded) periodic driving leads to a stochastic resonance-like
phenomenon. We demonstrate that the analysis of such data can be used to
extract four basic parameters of such a transition and discuss the statistical
requirements of the data acquisition. As advantages of the proposed scheme, a
polymeric linker is explicitly included and thermal fluctuations within each
well need not to be resolved.Comment: 7 pages, 5 figures, submitted to EP
Tube Width Fluctuations in F-Actin Solutions
We determine the statistics of the local tube width in F-actin solutions,
beyond the usually reported mean value. Our experimental observations are
explained by a segment fluid theory based on the binary collision approximation
(BCA). In this systematic generalization of the standard mean-field approach
effective polymer segments interact via a potential representing the
topological constraints. The analytically predicted universal tube width
distribution with a stretched tail is in good agreement with the data.Comment: Final version, 5 pages, 4 figure
Coupling JOREK and STARWALL for Non-linear Resistive-wall Simulations
The implementation of a resistive-wall extension to the non-linear MHD-code
JOREK via a coupling to the vacuum-field code STARWALL is presented along with
first applications and benchmark results. Also, non-linear saturation in the
presence of a resistive wall is demonstrated. After completion of the ongoing
verification process, this code extension will allow to perform non-linear
simulations of MHD instabilities in the presence of three-dimensional resistive
walls with holes for limited and X-point plasmas.Comment: Contribution for "Theory Of Fusion Plasmas, Joint Varenna - Lausanne
International Workshop, Villa Monastero, Varenna, Italy (27.-31.8.2012)",
accepted for publication in Journal of Physics Conference Serie
funcX: A Federated Function Serving Fabric for Science
Exploding data volumes and velocities, new computational methods and
platforms, and ubiquitous connectivity demand new approaches to computation in
the sciences. These new approaches must enable computation to be mobile, so
that, for example, it can occur near data, be triggered by events (e.g.,
arrival of new data), be offloaded to specialized accelerators, or run remotely
where resources are available. They also require new design approaches in which
monolithic applications can be decomposed into smaller components, that may in
turn be executed separately and on the most suitable resources. To address
these needs we present funcX---a distributed function as a service (FaaS)
platform that enables flexible, scalable, and high performance remote function
execution. funcX's endpoint software can transform existing clouds, clusters,
and supercomputers into function serving systems, while funcX's cloud-hosted
service provides transparent, secure, and reliable function execution across a
federated ecosystem of endpoints. We motivate the need for funcX with several
scientific case studies, present our prototype design and implementation, show
optimizations that deliver throughput in excess of 1 million functions per
second, and demonstrate, via experiments on two supercomputers, that funcX can
scale to more than more than 130000 concurrent workers.Comment: Accepted to ACM Symposium on High-Performance Parallel and
Distributed Computing (HPDC 2020). arXiv admin note: substantial text overlap
with arXiv:1908.0490
Non-linear Simulations of MHD Instabilities in Tokamaks Including Eddy Current Effects and Perspectives for the Extension to Halo Currents
The dynamics of large scale plasma instabilities can strongly be influenced
by the mutual interaction with currents flowing in conducting vessel
structures. Especially eddy currents caused by time-varying magnetic
perturbations and halo currents flowing directly from the plasma into the walls
are important. The relevance of a resistive wall model is directly evident for
Resistive Wall Modes (RWMs) or Vertical Displacement Events (VDEs). However,
also the linear and non-linear properties of most other large-scale
instabilities may be influenced significantly by the interaction with currents
in conducting structures near the plasma. The understanding of halo currents
arising during disruptions and VDEs, which are a serious concern for ITER as
they may lead to strong asymmetric forces on vessel structures, could also
benefit strongly from these non-linear modeling capabilities. Modeling the
plasma dynamics and its interaction with wall currents requires solving the
magneto-hydrodynamic (MHD) equations in realistic toroidal X-point geometry
consistently coupled with a model for the vacuum region and the resistive
conducting structures. With this in mind, the non-linear finite element MHD
code JOREK has been coupled with the resistive wall code STARWALL, which allows
to include the effects of eddy currents in 3D conducting structures in
non-linear MHD simulations. This article summarizes the capabilities of the
coupled JOREK-STARWALL system and presents benchmark results as well as first
applications to non-linear simulations of RWMs, VDEs, disruptions triggered by
massive gas injection, and Quiescent H-Mode. As an outlook, the perspectives
for extending the model to halo currents are described.Comment: Proceeding paper for Theory of Fusion Plasmas (Joint Varenna-Lausanne
International Workshop), Varenna, Italy (September 1-5, 2014); accepted for
publication in: to Journal of Physics: Conference Serie
Masked millennial-scale climate variations in South West Africa during the last glaciation
To address the connection between tropical African vegetation development and high-latitude climate change we present a high-resolution pollen record from ODP Site 1078 (off Angola) covering the period 50–10 ka BP. Although several tropical African vegetation and climate reconstructions indicate an impact of Heinrich Stadials (HSs) in Southern Hemisphere Africa, our vegetation record shows no response. Model simulations conducted with an Earth System Model of Intermediate Complexity including a dynamical vegetation component provide one possible explanation. Because both precipitation and evaporation increased during HSs and their effects nearly cancelled each other, there was a negligible change in moisture supply. Consequently, the resulting climatic response to HSs might have been too weak to noticeably affect the vegetation composition in the study area. Our results also show that the response to HSs in southern tropical Africa neither equals nor mirrors the response to abrupt climate change in northern Africa
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