Screening for gastroesophageal reflux disease

The Purpose of research. To estimate a role of screening in revealing sick gastroesophageal reflux disease (GERD) and training of these patients in «To School of patients GERD» at an dispensary-polyclinic stage by means of studying an estimation of quality of a life. Materials and methods. Tests for presence gastroesophageal reflux disease developed by professor V.A. Isakovym (MRSRI n. M.F.Vladimirsky) and an estimation of quality of a life (questionnaire SF-36 created J.E. Ware) have passed 180 patients who have addressed the dispensary-polyclinic help. By results of testing interrogated have been divided into 2 groups: 1-st with presence gastroesophageal reflux disease, 2-nd — without symptoms gastroesophageal a reflux. An estimation of quality of a life spent a method of summation of estimations Likerti on the basis of code conversion of intermediate values by means of the software distributed by company QMetric Inc (MOS SF-36. The Health Institute, New England Medical Center, Boston, USA). Retrospectivity electronic out-patient cards of all patients are studied, results esophagogastroduodenoscopy and contrast rentghenoskopy the top departments of a digestive path are analysed. Results. More than half of the patients who have addressed the dispensary-polyclinic help, had symptoms gastroesophageal reflux disease. Gastroesophageal reflux disease proceeded under «Masks» other diseases, and their mutual influence led to a syndrome of mutual burdening. The conclusion. Screening of patients at an dispensary stage allows to reveal symptoms gastroesophageal a reflux, to define further tactics of inspection and treatment, and training of patients will allow to reduce clinical displays of this pathology and to warn complications.Цель исследования. Оценить роль скрининга в выявлении больных гастроэзофагеальной рефлюксной болезнью (ГЭРБ) и обучения этих пациентов в «Школе больных ГЭРБ» на амбулаторно-поликлиническом этапе с помощью изучения оценки качества жизни. Материалы и методы. Тесты на наличие гастроэзофагеальной рефлюксной болезни, разработанные профессором В.А. Исаковым (МОНИКИ им. М.Ф. Владимирского) и оценку качества жизни (опросник SF-36, созданный J.E. Ware) прошли 180 пациентов, обратившихся за амбулаторно-поликлинической помощью. По результатам тестирования опрошенные были разделены на 2 группы: 1-я с наличием гастроэзофагеальной рефлюксной болезни, 2-я — без симптомов гастро-эзофагеального рефлюкса. Оценку качества жизни проводили методом суммирования оценок Ликерта на основе перекодировки промежуточных значений с помощью программного обеспечения, распространяемого компанией QMetric Inc (MOS SF-36. The Health Institute, New England Medical Center, Boston, USA). Ретроспективно изучены электронные амбулаторные карты всех больных, проанализированы результаты ФГДС и контрастной рентгеноскопии верхних отделов пищеварительного тракта. Результаты. Более половины пациентов, обратившихся за амбулаторно-поликлинической помощью, имели симптомы гастроэзофагеальной рефлюксной болезни. Гастроэзофагеальная рефлюксная болезнь протекала под «масками» других заболеваний, а их взаимное влияние приводило к синдрому взаимного отягощения. Заключение. Скрининг пациентов на амбулаторном этапе позволяет выявить симптомы гастроэзофагеального рефлюкса, определить дальнейшую тактику обследования и лечения, а обучение больных позволит уменьшить клинические проявления этой патологии и предупредить осложнения

State total microcirculation in patients with hemophilia

The paper presents the results of the study total microcirculation in patients with hemophilia, obtained using laser Doppler flowmetry. Revealed asymmetric reduction of perfusion, increase the maximum amplitude of violations of microcirculation

Evaluation of anemia syndrom in haemophilia

In work risk factors of development of an anemia at patients with a hemophilia are analyzed. The anemia met more often at the heavy form of disease, at persons with A (II) group of blood (40%)

Standardization of measles, mumps and rubella assays to enable comparisons of seroprevalence data across 21 European countries and Australia

The aim of the European Sero-Epidemiology Network is to establish comparability of the serological surveillance of vaccine-preventable diseases in Europe. The designated reference laboratory (RL) for measles, mumps, rubella (MMR) prepared and tested a panel of 151 sera by the reference enzyme immunoassay (rEIA). Laboratories in 21 countries tested the panel for antibodies against MMR using their usual assay (a total of 16 different EIAs) and the results were plotted against the reference results in order to obtain equations for the standardization of national serum surveys. The RL also tested the panel by the plaque neutralization test (PNT). Large differences in qualitative results were found compared to the RL. Well-fitting standardization equations with R20·8 were obtained for almost all laboratories through regression of the quantitative results against those of the RL. When compared to PNT, the rEIA had a sensitivity of 95·3%, 92·8% and 100% and a specificity of 100%, 87·1% and 92·8% for measles, mumps and rubella, respectively. The need for standardization was highlighted by substantial inter-country differences. Standardization was successful and the selected standardization equations allowed the conversion of local serological results into common units and enabled direct comparison of seroprevalence data of the participating countrie

Risk factors of development of complications at the hemophilia

In work the data on influence of internal factors on current congenital coagulopathies. Groups of risk on development of complications are allocated at a hemophilia

Estimation of physical development on recurrent haemartrosis at the hemophilia

In work the data on interrelation of parameters of physical development and expressiveness of inflammatory changes in joints are submitted according to clinical and termografical researches at patients with a hemophilia