Mapping mean and variance of runoff in a river basin

International audienceThe study presents an approach to depict the two first order moments of runoff as a function of area (and thus on a map). The focal point is the mapping of the statistical properties of runoff q=q(A,D) in space (area A) and time (time interval D). The problem is divided into two steps. Firstly the first order moment (the long term mean value) is analysed and mapped applying an interpolation procedure for river runoff. In a second step a simple random model for the river runoff process is proposed for the instantaneous point runoff normalised with respect to the long term mean. From this model theoretical expressions for the time-space variance-covariance of the inflow to the river network are developed, which then is used to predict how the second order moment vary along rivers from headwaters to the mouth. The observation data are handled in the frame of a hydrological information system HydroDem, which allows displaying the results either in the form of area dependence of moments along the river branches to the basin outlet or as a map of the variation of the moments across the basin space. The findings are demonstrated on the example of the Moselle drainage basin (French part)

Mapping mean monthly runoff pattern using EOF analysis

International audienceRunoff generation in a forested catchment (0.18 km2) was simulated using a quasi-three-dimensional rainfall-runoff model. The model was formulated over a finite grid where water movement was assumed to be dominantly vertical in the unsaturated soil zone and horizontal in the saturated soil. The vertical soil moisture distribution at each grid cell was calculated using a conceptual approximation to the one-dimensional Richards equation. The approximation allowed the use of a simple soil surface boundary condition and an efficient solution to the water table elevation over the finite grid. The approximation was coupled with a two-dimensional ground water model to calculate lateral soil water movement between the grid cells and exfiltration over saturated areas, where runoff was produced by the saturation-excess mechanism. Runoff was an input to a channel network, which was modelled as a nonlinear reservoir. The proposed approximation for the vertical soil moisture distribution in unsaturated soil compared well to a numerical solution of the Richards equation during shallow water table conditions, but was less satisfactory during prolonged dry periods. The simulation of daily catchment outflow was successful with the exception of underprediction of extremely high peak flows. The calculated water table depth compared satisfactorily with the measurements. An overall comparison with the earlier results of tracer studies indicated that the modelled contribution of direct rainfall/snowmelt in streamflow was higher than the isotopically traced fraction of event-water in runoff. The seasonal variation in the modelled runoff-contributing areas was similar to that in the event-water-contributing areas from the tracer analysis

The perceptions of social responsibility for community resilience to flooding: the impact of past experience, age, gender and ethnicity

Community resilience to flooding depends, to a large extent, on the participation of community members to take more responsibility for enhancing their own resilience. The perception of social responsibility (SR) which is argued to be one of the antecedents influencing individual’s willingness to undertake resilient behaviours can significantly contribute to community resilience through individual and collective actions. Understanding of factors influencing the perceptions of SR of individuals within community might help with developing strategies to increase the perceptions of SR. This research explores perceptions of SR in relation to flooding for householders and local businesses and establishes their relationships with experience of flooding and demographic factors of age, gender and ethnicity. The data were obtained via a questionnaire survey of three communities in Birmingham and one community in South East London, UK, three with experience of flooding and one without. A total of 414 responses were received and used in the multiple regression analysis. The analysis identified ‘experience of flooding’, ‘age’ and ‘South Asian’ ethnic group as significant variables, suggesting that older individuals from South Asian ethnic groups with previous experience of flooding are likely to be more socially responsible than others without these attributes

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Mapping mean monthly runoff pattern using EOF analysis

Runoff generation in a forested catchment (0.18 km²) was simulated using a quasi-three-dimensional rainfall-runoff model. The model was formulated over a finite grid where water movement was assumed to be dominantly vertical in the unsaturated soil zone and horizontal in the saturated soil. The vertical soil moisture distribution at each grid cell was calculated using a conceptual approximation to the one-dimensional Richards equation. The approximation allowed the use of a simple soil surface boundary condition and an efficient solution to the water table elevation over the finite grid. The approximation was coupled with a two-dimensional ground water model to calculate lateral soil water movement between the grid cells and exfiltration over saturated areas, where runoff was produced by the saturation-excess mechanism. Runoff was an input to a channel network, which was modelled as a nonlinear reservoir. The proposed approximation for the vertical soil moisture distribution in unsaturated soil compared well to a numerical solution of the Richards equation during shallow water table conditions, but was less satisfactory during prolonged dry periods. The simulation of daily catchment outflow was successful with the exception of underprediction of extremely high peak flows. The calculated water table depth compared satisfactorily with the measurements. An overall comparison with the earlier results of tracer studies indicated that the modelled contribution of direct rainfall/snowmelt in streamflow was higher than the isotopically traced fraction of event-water in runoff. The seasonal variation in the modelled runoff-contributing areas was similar to that in the event-water-contributing areas from the tracer analysis