Atypical tumor-like mass os canine visceral leishmaniasis

Submitted by Repositório Arca ([email protected]) on 2019-04-24T17:38:47Z No. of bitstreams: 1 license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5)Approved for entry into archive by Janaína Nascimento ([email protected]) on 2019-08-27T12:33:51Z (GMT) No. of bitstreams: 2 ve_Honse_C_etal_INI_2015.pdf: 650366 bytes, checksum: 80457e8dbafdf255674c6c7db7bf46a8 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5)Made available in DSpace on 2019-08-27T12:33:51Z (GMT). No. of bitstreams: 2 ve_Honse_C_etal_INI_2015.pdf: 650366 bytes, checksum: 80457e8dbafdf255674c6c7db7bf46a8 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2015Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Vigilância em Leishmaniose. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Faculdade de Veterinária. Departamento de Patologia Clínica Veterinária. Laboratório Clínico Veterinário. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos. Rio de Janeiro, RJ, Brasil.Canine visceral leishmaniasis is an important zoonosis caused by the protozoa Leishmania infantum (syn. Leishmania chagasi), whose clinical manifestations are dependent on the immune response expressed by the infected animal and the virulence of the parasite. Atypical clinical forms of canine visceral leishmaniasis have been reported. The purpose of this paper was to describe a tumor-like lesion form of canine visceral leishmaniasis and to alert clinical and pathologists veterinarians to the importance of its diagnosis. Amastigote forms were observed by cytopathological, histopathological and immunohistochemistry analysis from the tumour-like lesion and Leishmania infantum was isolated by culture from spleen, liver, lymph nodes and bone marrow samples. Clinical and pathologist veterinarians should include the canine visceral leishmaniasis in the differential diagnosis of tumors and chronic affections of oral mucosa, mainly in endemic regions of the disease

Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis

SOUZA, Elaine Waite de et al. Clinical features, fungal load, coinfections, histological skin changes, and itraconazole treatment response of cats with sporotrichosis caused by Sporothrix brasiliensis. Scientific Reports, v. 8, p. 1-10, 2018.Submitted by Rodrigo Menezes ([email protected]) on 2018-07-15T23:56:46Z No. of bitstreams: 1 Souza_et_al-2018-Scientific_Reports.pdf: 1890404 bytes, checksum: d0fc4182b13d4a922bcba16273624d7e (MD5)Approved for entry into archive by Raquel Dinelis ([email protected]) on 2018-07-30T18:13:40Z (GMT) No. of bitstreams: 1 Souza_et_al-2018-Scientific_Reports.pdf: 1890404 bytes, checksum: d0fc4182b13d4a922bcba16273624d7e (MD5)Made available in DSpace on 2018-07-30T18:13:40Z (GMT). No. of bitstreams: 1 Souza_et_al-2018-Scientific_Reports.pdf: 1890404 bytes, checksum: d0fc4182b13d4a922bcba16273624d7e (MD5) Previous issue date: 2018Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.School of Veterinary Medicine. Louisiana State University, Baton Rouge. Los Angeles, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Zoonotic sporotrichosis caused by the fungus Sporothrix brasiliensis is usually severe in cats. This study investigated the associations between clinical features, fungal load, coinfections, histological skin changes, and response to itraconazole in cats with sporotrichosis caused by S. brasiliensis. Fifty-two cats with skin lesions and a definitive diagnosis of sporotrichosis were treated with itraconazole for a maximum period of 36 weeks. The animals were submitted to clinical examination and two subsequent collections of samples from the same skin lesion for fungal diagnosis and histopathology, as well as serology for feline immunodeficiency (FIV) and leukaemia (FeLV) viruses. Thirty-seven (71%) cats were clinically cured. Nasal mucosa lesions and respiratory signs were associated with treatment failure. Cats coinfected with FIV/FeLV (n = 12) had a lower neutrophil count in the lesion. A high fungal load in skin lesions was linked to young age and treatment failure, as well as to a longer time of wound healing, poorly formed granulomas and fewer neutrophils, macrophages and lymphocytes in these lesions. These results indicate that itraconazole is effective, but nasal mucosal involvement, respiratory signs and high fungal loads in skin lesions are predictors of treatment failure that will assist in the development of better treatment protocols for cats