1,008 research outputs found
Synchronization of unidirectional time delay chaotic networks and the greatest common divisor
We present the interplay between synchronization of unidirectional coupled
chaotic nodes with heterogeneous delays and the greatest common divisor (GCD)
of loops composing the oriented graph. In the weak chaos region and for GCD=1
the network is in chaotic zero-lag synchronization, whereas for GCD=m>1
synchronization of m-sublattices emerges. Complete synchronization can be
achieved when all chaotic nodes are influenced by an identical set of delays
and in particular for the limiting case of homogeneous delays. Results are
supported by simulations of chaotic systems, self-consistent and mixing
arguments, as well as analytical solutions of Bernoulli maps.Comment: 7 pages, 5 figure
Solvation vs. freezing in a heteropolymer globule
We address the response of a random heteropolymer to preferential solvation
of certain monomer types at the globule-solvent interface. For each set of
monomers that can comprise the molecule's surface, we represent the ensemble of
allowed configurations by a Gaussian distribution of energy levels, whose mean
and variance depend on the set's composition. Within such a random energy
model, mean surface composition is proportional to solvation strength under
most conditions. The breadth of this linear response regime arises from
approximate statistical independence of surface and volume energies. For a
diverse set of monomer types, the excess of solvophilic monomers at the surface
is large only for very strong solvent preference, even in the ground state.Comment: 10 pages, 1 figur
Homodyne and heterodyne X-ray photon correlation spectroscopy: latex particles and elastomers
Galileo dust data from the jovian system: 2000 to 2003
The Galileo spacecraft was orbiting Jupiter between Dec 1995 and Sep 2003.
The Galileo dust detector monitored the jovian dust environment between about 2
and 370 R_J (jovian radius R_J = 71492 km). We present data from the Galileo
dust instrument for the period January 2000 to September 2003. We report on the
data of 5389 particles measured between 2000 and the end of the mission in
2003. The majority of the 21250 particles for which the full set of measured
impact parameters (impact time, impact direction, charge rise times, charge
amplitudes, etc.) was transmitted to Earth were tiny grains (about 10 nm in
radius), most of them originating from Jupiter's innermost Galilean moon Io.
Their impact rates frequently exceeded 10 min^-1. Surprisingly large impact
rates up to 100 min^-1 occurred in Aug/Sep 2000 when Galileo was at about 280
R_J from Jupiter. This peak in dust emission appears to coincide with strong
changes in the release of neutral gas from the Io torus. Strong variability in
the Io dust flux was measured on timescales of days to weeks, indicating large
variations in the dust release from Io or the Io torus or both on such short
timescales. Galileo has detected a large number of bigger micron-sized
particles mostly in the region between the Galilean moons. A surprisingly large
number of such bigger grains was measured in March 2003 within a 4-day interval
when Galileo was outside Jupiter's magnetosphere at approximately 350 R_J
jovicentric distance. Two passages of Jupiter's gossamer rings in 2002 and 2003
provided the first actual comparison of in-situ dust data from a planetary ring
with the results inferred from inverting optical images.Comment: 59 pages, 13 figures, 6 tables, submitted to Planetary and Space
Scienc
Nonlocal mechanism for cluster synchronization in neural circuits
The interplay between the topology of cortical circuits and synchronized
activity modes in distinct cortical areas is a key enigma in neuroscience. We
present a new nonlocal mechanism governing the periodic activity mode: the
greatest common divisor (GCD) of network loops. For a stimulus to one node, the
network splits into GCD-clusters in which cluster neurons are in zero-lag
synchronization. For complex external stimuli, the number of clusters can be
any common divisor. The synchronized mode and the transients to synchronization
pinpoint the type of external stimuli. The findings, supported by an
information mixing argument and simulations of Hodgkin Huxley population
dynamic networks with unidirectional connectivity and synaptic noise, call for
reexamining sources of correlated activity in cortex and shorter information
processing time scales.Comment: 8 pges, 6 figure
Molecular genetics and pathophysiology of 17 beta-hydroxysteroid dehydrogenase 3 deficiency.
Autosomal recessive mutations in the 17 beta-hydroxysteroid dehydrogenase 3 gene impair the formation of testosterone in the fetal testis and give rise to genetic males with female external genitalia. Such individuals are usually raised as females, but virilize at the time of expected puberty as the result of increases in serum testosterone. Here we describe mutations in 12 additional subjects/families with this disorder. The 14 mutations characterized to date include 10 missense mutations, 3 splice junction abnormalities, and 1 small deletion that results in a frame shift. Three of these mutations have occurred in more than 1 family. Complementary DNAs incorporating 9 of the 10 missense mutations have been constructed and expressed in reporter cells; 8 of the 9 missense mutations cause almost complete loss of enzymatic activity. In 2 subjects with loss of function, missense mutations testosterone levels in testicular venous blood were very low. Considered together, these findings strongly suggest that the common mechanism for testosterone formation in postpubertal subjects with this disorder is the conversion of circulating androstenedione to testosterone by one or more of the unaffected 17 beta-hydroxysteroid dehydrogenase isoenzymes
Reversible stretching of homopolymers and random heteropolymers
We have analyzed the equilibrium response of chain molecules to stretching.
For a homogeneous sequence of monomers, the induced transition from compact
globule to extended coil below the -temperature is predicted to be
sharp. For random sequences, however, the transition may be smoothed by a
prevalence of necklace-like structures, in which globular regions and coil
regions coexist in a single chain. As we show in the context of a random
copolymer, preferential solvation of one monomer type lends stability to such
structures. The range of stretching forces over which necklaces are stable is
sensitive to chain length as well as sequence statistics.Comment: 14 pages, 4 figure
Mechanical response of random heteropolymers
We present an analytical theory for heteropolymer deformation, as exemplified
experimentally by stretching of single protein molecules. Using a mean-field
replica theory, we determine phase diagrams for stress-induced unfolding of
typical random sequences. This transition is sharp in the limit of infinitely
long chain molecules. But for chain lengths relevant to biological
macromolecules, partially unfolded conformations prevail over an intermediate
range of stress. These necklace-like structures, comprised of alternating
compact and extended subunits, are stabilized by quenched variations in the
composition of finite chain segments. The most stable arrangements of these
subunits are largely determined by preferential extension of segments rich in
solvophilic monomers. This predicted significance of necklace structures
explains recent observations in protein stretching experiments. We examine the
statistical features of select sequences that give rise to mechanical strength
and may thus have guided the evolution of proteins that carry out mechanical
functions in living cells.Comment: 10 pages, 6 figure
The biocompatibility of titanium in a buffer solution: compared effects of a thin film of TiO2 deposited by MOCVD and of collagen deposited from a gel
This study aims at evaluating the biocompatibility of titanium surfaces modified according two different ways: (i) deposition of a bio-inert, thin film of rutile TiO2 by chemical vapour deposition (MOCVD), and (ii) biochemical treatment with collagen gel, in order to obtain a bio-interactive coating. Behind the comparison is the idea that either the bio-inert or the bio-active coating has specific advantages when applied to implant treatment, such as the low price of the collagen treatment for instance. The stability in buffer solution was evaluated by open circuit potential (OCP) for medium time and cyclic voltametry. The OCP stabilized after 5104 min for all the specimens except the collagen treated sample which presented a stable OCP from the first minutes. MOCVD treated samples stabilized to more electropositive values. Numeric results were statistically analysed to obtain the regression equations for long time predictable evolution. The corrosion parameters determined from cyclic curves revealed that the MOCVD treatment is an efficient way to improve corrosion resistance. Human dermal fibroblasts were selected for cell culture tests, taking into account that these cells are present in all bio-interfaces, being the main cellular type of connective tissue. The cells grew on either type of surface without phenotype modification. From the reduction of yellow, water-soluble 3-(4,5-dimethyldiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT cytotoxicity test), MOCVD treated samples offer better viability than mechanically polished Ti and collagen treated samples as well. Cell spreading, as evaluated from microscope images processed by the program Sigma Scan, showed also enhancement upon surface modification. Depending on the experimental conditions, MOCVD deposited TiO2 exhibits different nanostructures that may influence biological behaviour. The results demonstrate the capacity of integration in simulated physiologic liquids for an implant pretreated by either method
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