6,107 research outputs found
The pre-outburst flare of the A 0535+26 August/September 2005 outburst
We study the spectral and temporal behavior of the High Mass X-ray Binary A
0535+26 during a `pre-outburst flare' which took place ~5 d before the peak of
a normal (type I) outburst in August/September 2005. We compare the studied
behavior with that observed during the outburst. We analyse RXTE observations
that monitored A 0535+26 during the outburst. We complete spectral and timing
analyses of the data. We study the evolution of the pulse period, present
energy-dependent pulse profiles both at the initial pre-outburst flare and
close to outburst maximum, and measure how the cyclotron resonance-scattering
feature (hereafter CRSF) evolves. We present three main results: a constant
period P=103.3960(5)s is measured until periastron passage, followed by a
spin-up with a decreasing period derivative of Pdot=(-1.69+/-0.04)x10^(-8)s/s
at MJD 53618, and P remains constant again at the end of the main outburst. The
spin-up provides evidence for the existence of an accretion disk during the
normal outburst. We measure a CRSF energy of Ecyc~50kev during the pre-outburst
flare, and Ecyc~46kev during the main outburst. The pulse shape, which varies
significantly during both pre-outburst flare and main outburst, evolves
strongly with photon energy.Comment: 4 pages, 4 figures, accepted for publication in A&A Letters. To be
published in parallel to Postnov et al. 200
Results and prospects on registration of reflected Cherenkov light of EAS from cosmic particles above 10^{15} eV
We give an overview of the SPHERE experiment based on detection of reflected
Vavilov-Cherenkov radiation (Cherenkov light) from extensive air showers in the
energy region E>10^{15} eV. A brief history of the reflected Cherenkov light
technique is given; the observations carried out with the SPHERE-2 detector are
summarized; the methods of the experimental datasample analysis are described.
The first results on the primary cosmic ray all-nuclei energy spectrum and mass
composition are presented. Finally, the prospects of the SPHERE experiment and
the reflected Cherenkov light technique are given.Comment: 4 pages, 3 figures, Proc. PANIC-201
Force Modulating Dynamic Disorder: Physical Theory of Catch-slip bond Transitions in Receptor-Ligand Forced Dissociation Experiments
Recently experiments showed that some adhesive receptor-ligand complexes
increase their lifetimes when they are stretched by mechanical force, while the
force increase beyond some thresholds their lifetimes decrease. Several
specific chemical kinetic models have been developed to explain the intriguing
transitions from the "catch-bonds" to the "slip-bonds". In this work we suggest
that the counterintuitive forced dissociation of the complexes is a typical
rate process with dynamic disorder. An uniform one-dimension force modulating
Agmon-Hopfield model is used to quantitatively describe the transitions
observed in the single bond P-selctin glycoprotein ligand
1(PSGL-1)P-selectin forced dissociation experiments, which were respectively
carried out on the constant force [Marshall, {\it et al.}, (2003) Nature {\bf
423}, 190-193] and the force steady- or jump-ramp [Evans {\it et al.}, (2004)
Proc. Natl. Acad. Sci. USA {\bf 98}, 11281-11286] modes. Our calculation shows
that the novel catch-slip bond transition arises from a competition of the two
components of external applied force along the dissociation reaction coordinate
and the complex conformational coordinate: the former accelerates the
dissociation by lowering the height of the energy barrier between the bound and
free states (slip), while the later stabilizes the complex by dragging the
system to the higher barrier height (catch).Comment: 8 pages, 3 figures, submitte
A 0535+26: an X-ray/Optical Tour
We compiled X-ray and Optical observations of the accreting X-ray binary
system A 0535+262 since its discovery in 1975, that will allow us to shed light
on the unpredictable behavior of this binary system. We present the data in
terms of the Be-disk interaction with the neutron star companion. In addition,
we show recent results from the continuous monitoring of this source by the
Gamma-ray Burst Monitor(GBM), on board the Fermi observatory, since its launch
in 2008 June 11.Comment: 4 pages, 5 figures, Conference proceeding of "Astrophysics of Neutron
Stars 2010 - a conference in honor of M. Ali Alpar", 2-6 August 2010, Cesme,
Izmir, Turke
Status of p53 in first-trimester cytotrophoblastic cells
p53 has been called the cellular gatekeeper of the genome because it can induce cell-cycle arrest in G1, apoptosis or affect DNA replication in response to DNA damage. As p53 has been observed in first-trimester cytotrophoblastic cells (CTB), but its expression in normal cells is generally not detectable because of its short half-life, p53 could play an important role in cellular differentiation and/or in the control of the invasion of trophoblastic cells; therefore, p53 status was investigated in these cells. Using different antibodies recognizing different epitopes of p53 protein, abundant p53 expression was observed both in nuclear and in cytoplasmic compartments of first-trimester CTB. Whereas p53 was detected in the nuclei of few trophoblastic cells with an antibody recognizing the N-terminal epitope of the protein, high expression level of p53 in the cytoplasm of CTB was detected with an antibody recognizing the middle part of p53. The lack of immunoreactivity of p53 with antibodies recognizing the epitopes located at the N-terminus of p53 and the high level of p53 protein observed in the cytoplasm of CTB suggest that the N-terminus of p53 is involved in the formation of complexes. These cytoplasmic complexes were detected under non-reducing conditions in western blot analysis and had apparent molecular weights (MW) of 195, 167 or 125 kDa. These complexes could prolong the half-life of p53 in the cytoplasm of CTBs. By contrast, in the nuclei of CTBs, p53 seems to be present as a tetrame
INTEGRAL observations of the Small Magellanic Cloud
The first INTEGRAL observations of the Small Magellanic Cloud (carried out in
2003) are reported in which two sources are clearly detected. The first source,
SMC X-1, shows a hard X-ray eclipse and measurements of its pulse period
indicate a continuation of the long-term spin-up now covering ~30 years. The
second source is likely to be a high mass X-ray binary, and shows a potential
periodicity of 6.8s in the IBIS lightcurve. An exact X-ray or optical
counterpart cannot be designated, but a number of proposed counterparts are
discussed. One of these possible counterparts shows a strong coherent optical
modulation at ~2.7d, which, together with the measured hard X-ray pulse period,
would lead to this INTEGRAL source being classified as the fourth known high
mass Roche lobe overflow system.Comment: Accepted for publication in MNRA
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