Rotura no traumática de componente cerámica-cerámica en PTC: presentación de un caso y revisión de la literatura.

Las fracturas de los componentes cerámicos empleados en artroplastia total de cadera (ATC) son infrecuentes. El objetivo de nuestro trabajo es presentar un caso de rotura precoz no traumática de componente ce - rámica-cerámica en ATC y revisar la literatura en relación con esta complicación. Se trata de un paciente de 58 años diagnosticado de necrosis avascular de cabeza femoral, fue intervenido mediante ATC, implantándosele un par cerámica-cerámica. A los 4 meses de la intervención, sin antecedente traumático previo, se observó fractura de la cúpula de cerámica de la prótesis. El paciente precisó de recambio protésico, utilizándose el par cerámica-polietileno. La fractura de los componentes del par cerámica- cerámica es poco frecuente. El fallo puede ser debido a un defecto de fabricación o en la colocación del implante. Los pacientes deben ser informados sobre la posibilidad de sufrir esta complicación antes de la implantación de una PTC con par cerámica-cerámica.Fractures of ceramic components used in total hip replacement (THR) are uncommon. To report a case of early non-traumatic rupture ceramic-ceramic component in THR and review the literature regarding this complication. A 58 years diagnosed with avascular necrosis of the femoral head, was operated by THR, a ceramic-on -ceramic. At 4 months after surgery, without previous trauma, fracture was observed ceramic dome of the prosthesis. The patient required replacement, using the ceramic-on-polyethylene. The fracture of ceramic components is rare. The failure may be due to a manufacturing defect or implant placement. Patients should be informed about the possi - bility of having this complication before implantation of a THR ceramic-on-ceramic

Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring

Backgroud: Prenatal alcohol exposure is a leading cause of neurobehavioral and neurocognitive deficits collectively known as fetal alcohol spectrum disorders (FASD), including eating disorders and increased risk for substance abuse as very common issues. In this context, the present study aimed to assess the interaction between alcohol exposure during gestation and lactation periods (PLAE) and a high fat diet (HFD) during childhood and adolescence. Methods: Pregnant C57BL/6 mice underwent a procedure for alcohol binge drinking during gestation and lactation periods. Subsequently, PLAE female offspring were fed with a HFD for 8 weeks and thereafter, nutrition-related parameters as well as their response to cocaine were assessed. Results: In our model, feeding young females with a HFD increased their triglyceride blood levels but did not induce an overweight compared to those fed with a standard diet. Moreover, PLAE affected how females responded to the fatty diet as they consumed less amount of food than water-exposed offspring, consistent with a lower gain of body weight. HFD increased the psychostimulant effects of cocaine. Surprisingly, PLAE reduced the locomotor responses to cocaine without modifying cocaine-induced reward. Moreover, PLAE prevented the striatal overexpression of cannabinoid 1 receptors induced by a HFD and induced an alteration of myelin damage biomarker in the prefrontal cortex, an effect that was mitigated by a HFD-based feeding. Conclusion: Therefore, in female offspring, some effects triggered by one of these factors, PLAE or a HFD, were blunted by the other, suggesting a close interaction between the involved mechanisms

Equity, barriers and cancer disparities: study of the Spanish Society of Medical Oncology on the access to oncologic drugs in the Spanish Regions

[Purpose] The Spanish Society of Medical Oncology (SEOM) has conducted a study on the access to oncologic drugs across the 17 Spanish Regions with the aim of identifying potential heterogeneities and making proposals for eliminating the barriers identified at the different levels.[Methods] An Expert Panel made up of medical oncologists designed a survey on certain indications approved for 11 drugs in the approach of breast cancer, melanoma, lung cancer, prostate cancer and support treatment. This survey was sent to 144 National Health System (NHS) hospitals. [Results] 77 hospitals answered the survey. The information modules analysed were: scope of the Commission that establishes binding decisions related to drug access; conditions, stages and periods of drug application, approval and administration processes; barriers to accessing drugs. [Conclusions] The study shows variability in drug access. The SEOM makes proposals addressed to reducing the differences identified and homogenizing drug access conditions.This study was funded by SEOM

Neuropsychopharmacologic and neurotoxicologic effects of the combination of ethanol with mephedrone in adolescent mice

Podeu consultar el llibre complet a: http://hdl.handle.net/2445/103042In the last decade, a new family of synthetic psychostimulant drugs, under the name of cathinones, broke into the market. These drugs are mainly consumed by adolescents and young adults with recreational purposes, in most cases combined with alcoholic drinks. Although a number of works about new cathinones have been recently published, none explored the consequences of such combination. Because adolescence is a crucial period in brain development, we sought to study the effects of the combination of mephedrone plus ethanol in adolescent mice, focusing on psychostimulant and conditioning effects, as well as on neurotoxicity markers. Ethanol increased both locomotor activity and conditioned place preference (CPP) induced by mephedrone. RNA microarray assays after CPP test yielded significant alterations in neuronal plasticity-related genes and a key role of BDNF and dopamine D3 receptors in CPP acquisition was found. Ethanol potentiated the oxidative stress as well as the decreases in dopaminergic and serotonergic markers in frontal cortex and hippocampus respectively, after a binge treatment with mephedrone. Moreover, the drug combination impaired spatial learning and memory, as well as neurogenesis to a higher extent than mephedrone alone

Post-transcriptional control of a stemness signature by RNA-binding protein MEX3A regulates murine adult neurogenesis

Neural stem cells (NSCs) in the adult murine subependymal zone balance their self-renewal capacity and glial identity with the potential to generate neurons during the lifetime. Adult NSCs exhibit lineage priming via pro-neurogenic fate determinants. However, the protein levels of the neural fate determinants are not sufficient to drive direct differentiation of adult NSCs, which raises the question of how cells along the neurogenic lineage avoid different conflicting fate choices, such as self-renewal and differentiation. Here, we identify RNA-binding protein MEX3A as a post-transcriptional regulator of a set of stemness associated transcripts at critical transitions in the subependymal neurogenic lineage. MEX3A regulates a quiescence-related RNA signature in activated NSCs that is needed for their return to quiescence, playing a role in the long-term maintenance of the NSC pool. Furthermore, it is required for the repression of the same program at the onset of neuronal differentiation. Our data indicate that MEX3A is a pivotal regulator of adult murine neurogenesis acting as a translational remodeller.© 2023. The Author(s)

Equity, barriers and cancer disparities: study of the Spanish Society of Medical Oncology on the access to oncologic drugs in the Spanish Regions

The Spanish Society of Medical Oncology (SEOM) has conducted a study on the access to oncologic drugs across the 17 Spanish Regions with the aim of identifying potential heterogeneities and making proposals for eliminating the barriers identified at the different levels. An Expert Panel made up of medical oncologists designed a survey on certain indications approved for 11 drugs in the approach of breast cancer, melanoma, lung cancer, prostate cancer and support treatment. This survey was sent to 144 National Health System (NHS) hospitals. 77 hospitals answered the survey. The information modules analysed were: scope of the Commission that establishes binding decisions related to drug access; conditions, stages and periods of drug application, approval and administration processes; barriers to accessing drugs. The study shows variability in drug access. The SEOM makes proposals addressed to reducing the differences identified and homogenizing drug access conditions