First Report of a Species of \u3ci\u3eFolliculovarium\u3c/i\u3e Gu & Shen, 1983 (Bucephalidae: Prosorhynchinae) from European Marine Waters, with the Description of \u3ci\u3eF. mediterraneum\u3c/i\u3e n. sp.

Folliculovarium mediterraneum n. sp. is described and figured in detail from the intestine of the Mediterranean moray eel Muraena helena (Muraenidae) in the Scandola Nature Reserve, off Corsica in the western Mediterranean. This new species closely resembles F. gymnothoracis Gu & Shen, 1983 and F. xishaense Gu & Shen, 1983 from marine fishes off China, but it may differ from both in not having specialized circum-rynchal spines. It differs from the former by having slightly larger eggs and a longer esophagus, and from F. xishaense by having tegumental spines, a longer esophagus, and a nonrelated host (an eel rather than a serranid). The status of Folliculovarium, which was recently treated as a genus inquirendum by Overstreet & Curran (2002), is clarified by its multilobed rather than follicular ovary and other features, and remains in the Prosorhynchinae (Bucephalidae)

Model of the meniscus of an ionic liquid ion source.

A simple model of the transfer of charge and ion evaporation in the meniscus of an ionic-liquid ion source working in the purely ionic regime is proposed on the basis of order-of-magnitude estimates which show that, in this regime, _i_ the flow in the meniscus is dominated by the viscosity of the liquid and is affected very little by the mass flux accompanying ion evaporation, and _ii_ the effect of the space charge around the evaporating surface is negligible and the evaporation current is controlled by the finite electrical conductivity of the liquid. The model predicts that a stationary meniscus of a very polar liquid undergoing ion evaporation is nearly hydrostatic and can exist only below a certain value of the applied electric field, at which the meniscus attains its maximum elongation but stays smooth. The electric current vs applied electric field characteristic displays a frozen regime of negligible ion evaporation at low fields and a conduction-controlled regime at higher fields, with a sharp transition between the two regimes owing to the high sensitivity of the ion evaporation rate to the electric field. A simplified treatment of the flow in the capillary or liquid layer through which liquid is delivered to the meniscus shows that the size of the meniscus decreases and the maximum attainable current increases when the feeding pressure is decreased, and that appropriate combinations of feeding pressure and pressure drop may lead to high maximum currents

Effective Lagrangian from Higher Curvature Terms: Absence of vDVZ Discontinuity in AdS Space

We argue that the van Dam-Veltman-Zakharov discontinuity arising in the $M^2 \to 0$ limit of the massive graviton through an explicit Pauli-Fierz mass term could be absent in anti de Sitter space. This is possible if the graviton can acquire mass spontaneously from the higher curvature terms or/and the massless limit $M^2\to 0$ is attained faster than the cosmological constant $\Lambda \to 0$. We discuss the effects of higher-curvature couplings and of an explicit cosmological term ($\Lambda$) on stability of such continuity and of massive excitations.Comment: 23 pages, Latex, the version to appear in Class. Quant. Gra

Polarization effects in the reaction e++e−→ρ++ρ−e^++e^-\to \rho^+ +\rho^- and determination of the ρ−\rho - meson form factors in the time--like region

The electron positron annihilation reaction into four pion production has been studied, through the channel $e^++e^-\to \bar \rho+\rho$. The differential (and total) cross sections and various polarization observables for this reaction have been calculated in terms of the electromagnetic form factors of the corresponding $\gamma^*\rho\rho$ current. The elements of the spin--density matrix of the $\rho -$meson were also calculated. Numerical estimations have been done, with the help of phenomenological form factors obtained in the space--like region of the momentum transfer squared and analytically extended to the time-like region.Comment: 19 pages, 2 figures, to appear in Phys Rev

Energy dissipation via acoustic emission in ductile crack initiation

This article presents a modeling approach to estimate the energy release due to ductile crack initiation in conjunction to the energy dissipation associated with the formation and propagation of transient stress waves typically referred to as acoustic emission. To achieve this goal, a ductile fracture problem is investigated computationally using the finite element method based on a compact tension geometry under Mode I loading conditions. To quantify the energy dissipation associated with acoustic emission, a crack increment is produced given a pre-determined notch size in a 3D cohesive-based extended finite element model. The computational modeling methodology consists of defining a damage initiation state from static simulations and linking such state to a dynamic formulation used to evaluate wave propagation and related energy redistribution effects. The model relies on a custom traction separation law constructed using full field deformation measurements obtained experimentally using the digital image correlation method. The amount of energy release due to the investigated first crack increment is evaluated through three different approaches both for verification purposes and to produce an estimate of the portion of the energy that radiates away from the crack source in the form of transient waves. The results presented herein propose an upper bound for the energy dissipation associated to acoustic emission, which could assist the interpretation and implementation of relevant nondestructive evaluation methods and the further enrichment of the understanding of effects associated with fracture

Role of extracellular vesicle-based cell-to-cell communication in multiple myeloma progression

Multiple myeloma (MM) progression closely depends on the bidirectional crosstalk between tumor cells and the surrounding microenvironment, which leads to the creation of a tumor supportive niche. Extracellular vesicles (EVs) have emerged as key players in the pathological interplay between the malignant clone and near/distal bone marrow (BM) cells through their biologically active cargo. Here, we describe the role of EVs derived from MM and BM cells in reprogramming the tumor microenvironment and in fostering bone disease, angiogenesis, immunosuppression, drug resistance, and, ultimately, tumor progression. We also examine the emerging role of EVs as new therapeutic agents for the treatment of MM, and their potential use as clinical biomarkers for early diagnosis, disease classification, and therapy monitoring

Mortality and Morbidity Following Endovascular Repair of Abdominal Aortic Aneurysms: Analysis of Two Single Centre Experiences

AbstractObjective to show how differences in anatomical and physiological risk factors can affect the outcome of endovascular repair of AAA by describing the experience of two centres with different selection policies. Methods one hundred and thirty-five patients (group I) were treated at Queen's Medical Centre (Nottingham, U.K.) using 101 in-house made and 34 manufactured stent-grafts. Median diameter, length and angulation of the proximal aneurysm neck were 26 mm, 27 mm, 40°, respectively. Seventy-six patients had ischaemic heart disease, 47 had left ventricular failure, median forced expiratory volume in one second (FEV1) was 83%, median creatinine was 100 μmol/l and median age was 72 years. Fifty patients (group II) were treated at Timone Hospital (Marseilles, France) using seven in-house made and 43 manufactured stent-grafts. Median diameter, length and angulation of the proximal aneurysm neck were 25 mm, 34 mm, 33°, respectively. Thirteen patients had ischaemic heart disease, two had left ventricular failure, median forced expiratory volume in one second was 101%, median creatinine was 108 μmol/l and mean age was 72 years. Results anatomical characteristics of the proximal neck were significantly worse in group I (p=0.02 for the three variables). Cardiac comorbidities were more frequent and mean FEV1 was lower in group I (p<0.0001 and p=0.001, respectively. Median aneurysm diameter was significantly greater in group I (65 mm) than in group II (53 mm) (p<0.001). Postoperative mortality was 9% and 0% in groups I and II respectively (p=0.03). The incidence of technical complications (groin wound complications and side branches endoleaks being excluded) was 20% and 0% in groups I and II, respectively (p=0.0006). Conclusion postoperative mortality and technical complication rates were significantly greater in group I than in group II, readily explained by poorer general condition and worse anatomical characteristics of the proximal neck in group I

Digital mental health interventions for anxiety and depressive symptoms in university students during the COVID-19 pandemic: A systematic review of randomized controlled trials

University students are particularly vulnerable to mental health issues, with anxiety and depression identified as the most common conditions. During the COVID-19 pandemic, social distancing, self-isolation, and difficulties linked to online teaching and learning have increased their burden of anxiety and depressive symptoms. Thus, the urgent need to intervene in favour of these vulnerable subjects, together with the difficulties in delivering in-person interventions because of lockdowns and restrictions, has led to prioritize digital mental health strategies. This study aimed at systematically reviewing the existing literature on digital mental health interventions targeting anxiety and depressive symptoms in university students during the COVID-19 emergency. Systematic searches of Medline, Embase, and PsycInfo databases identified eight randomized controlled trials. Regarding anxiety symptoms, digitally delivered cognitive behavioural therapy, dialectical behaviour therapy, and mind-body practice techniques emerged as valid strategies, while digital positive psychology and mindfulness-based interventions showed mixed results. On the other hand, digitally delivered dialectical behaviour therapy and positive psychology interventions have shown some efficacy in reducing depressive symptoms. Overall, the available literature, albeit of low quality, seems to support the role of digital interventions in promoting the mental health of university students during the COVID-19 pandemic