Neuro Hub; an Insight to Neurological Disorders

In a protein- protein interaction network highly connected proteins are known as hubproteins. Hub proteins play a crucial part in the modular structure of the protein interaction network. They play a fundamental part in a wide range of biological processes in a number of different ways, and they are also to responsible for a number of diseases like cancer, auto immune disorders, and neuro degenerative illnesses. Among them the most common one is neuro degenerative disease. In order to give information about neuro degenerative diseases brought on by hub proteins, a database called Neuro Hub was established. Electronic databases maintain data in a persistent, non- volatile form that allows operations to be repeated and compared with other operations, with the results communicated to other researchers and developers. “Neuro Hub” is a database which was developed using CSS, HTML and Javascript. It contains information on neuro degenerative diseases caused by hub proteinsgallery of neuro hubs, references and new events showing the updated information. Currently there is no database connecting hub protein and neuro degenerative disorders. Hence “Neuro Hubs remains as a primary accession point for retrieving information related to hub proteins responsible for neuro degenerative diseases. Researchers are trying to solve the mystery and stigma associated with this disease and the discipline Bioinformatics it will be a useful one. The development of high- throughput technologies has generated large amount of sequence and structural data. These huge amounts of data are available in public domain databases but mining the specific data is quite a Herculean task. These challenges can be overcome from the database“Neuro hub”

Efektivitas Konseling Behavioral Teknik Assertive Training untuk Meminimalisasi Perilaku Menyimpang pada Siswa Kelas VIII SMP Negeri 2 Singaraja Tahun Pelajaran 2013/2014

Tujuan penelitian ini secara umum adalah untuk mengetahui efektifitas konseling behavioral untuk meminimalisasi perilaku menyimpang pada siswa kelas VIII SMP Negeri 2 Singaraja tahun pelajaran 2013/2014. Jenis penelitian ini adalah penelitian eksperimen dengan desain “Postest Only Control Group Design”. Populasi penelitian adalah siswa kelas VIII SMP Negeri 2 Singaraja tahun pelajaran 2013/2014 dengan N=575. Sampel Penelitian ditetapkan 82 orang yang pengambilan sampelnya dilakukan dengan teknik Group Random Sampling. Metode pengumpulan data yang digunakan dalam penelitian ini adalah metode kuesioner. Data penelitian dianalisis dengan teknik statistik t-test dan dibantu dengan program Microsoft office excel 2007 dan SPSS 16.0 for windows. Hasil penelitian ini menunjukkan bahwa : (1) terdapat perbedaan signifikan perilaku menyimpang antara kelompok siswa yang mengikuti dengan kelompok siswa yang tidak mengikuti konseling behavioral di kelas VIII SMP Negeri 2 Singaraja hal ini dilihat dari mean kelompok siswa yang mengikuti konseling behavioral (133,17) dengan kelompok siswa yang tidak mengikuti konseling behavioral (85,32), hal ini dilihat dari hasil analisis nilai thitung lebih besar dari ttabel dengan df =82 Dan taraf signifikansi 1% (t=0,053, p < 0,01). Sehingga penerapan konseling behavioral teknik assertive Training untuk meminimalisasi perilaku menyimpang pada siswa kelas VIII SMP Negeri 2 Singaraja tahun pelajaran 2013/2014 efektifKata Kunci : Kata kunci : konseling behavioral, assertive training, perilaku menyimpang The purpose of this study was to determine the general effectiveness of behavioral counseling to minimize deviant behavior in the eighth grade students of SMP Negeri 2 Singaraja school year 2013/2014. This research is an experimental research design with "post-test Only Control Group Design". The study population is the eighth grade students of SMP Negeri 2 Singaraja school year 2013/2014 with N = 575. The study sample set 82 men who carried out the sample collection Group Random Sampling technique. Data collection methods used in this study is a questionnaire method. Data were analyzed by t-test statistical techniques and assisted with the program Microsoft office excel 2007 and SPSS 16.0 for Windows. The results of this study indicate that: (1) there are significant differences in deviant behavior among groups of students who follow the group of students who do not follow the behavioral counseling in Junior High School eighth grade 2 Singaraja it is seen from the mean of the group of students who take (133.17) with group students who do not follow (85.32), it is seen from the results of the analysis tcount greater than t table with df = 82 and 1% significance level (t = 0.053,

Clinical profile of hepatocellular carcinoma and experience with sorafenib from a tertiary cancer centre in Southern India

Background: Hepatocellular carcinoma is a major health problem and a major cause of cancer mortality in India. There are no reports published on experience with sorafenib in advanced HCC from India. We analyzed the clinical presentation, possible etiological factors, tumor characteristics, outcomes and tolerability of sorafenib in the patients presenting to present cancer center.Methods: Retrospective chart review of 53 patients was done. 53 patients (male 37, female 16; median age 52 years, range 7-80 years) fulfilling the diagnostic criteria were analyzed for clinical characteristics, hematological and biochemical investigations, tumor characteristics, treatment taken and outcome.Results: 53 patients were diagnosed to have HCC between 2012-2015. Hepatitis B virus infection was the most common underlying etiologic factor (22.6%). Heavy alcohol intake was seen in 5 patients. PS ≥2 was noted in 66% of patients. 68% of the patients had BCLC stage C. Sorafenib was well tolerated with median OS of 3 months in patients taking sorafenib.Conclusions: Most of the patients had advanced inoperable HCC. Majority of the patients presented with BCLC Stage C and D. Hepatitis B infection was the most common underlying etiology. Sorafenib was well tolerated. More prospective studies are required for getting a clearer and correct picture of HCC and experience with sorafenib in Indian scenario

Essential Oil of Phyllanthus reticulatus Poiret from Nigeria

The chemical composition of the essential oil obtained by hydrodistillation from the leaves of Phyllanthus reticulatus Poiret (Euphorbiaceae) growing in Nigeria has been studied. The constituents of the oil were analyzed by means of gas chromatography (GC-FID) and gas chromatography coupled with mass spectrometry (GC-MS). Monoterpenes (64.9%) were the dominant class of compounds, followed by sesquiterpenes (23.0%). The major constituents were α-pinene (6.0%), sabinene (7.6%), β-pinene (18.1%), linalool (6.9%) and camphor (7.7%), among the monoterpenes, and β-caryophyllene (11.9%) and germacrene D (8.6%) among the sesquiterpenes. This is the first report on the volatile constituents of Phyllanthus reticulatu

Demographic and clinicopathologic profile of malignant epithelial ovarian tumors: an experience from a tertiary cancer care centre in Bangalore, South India

Background: Ovarian cancer is fast emerging as the leading cancer of the female genital tract. It is the second most common gynecological malignancy in India, but has poor outcomes making it the leading cause of gynecologic cancer related deaths. There is a paucity of data regarding demographic details, patterns of care and outcomes of ovarian epithelial malignancies in India. This is a study to evaluate the demographic details, clinical profile and pathology details of epithelial ovarian cancer registering in atertiary cancer center in Bangalore, Karnataka, India.Methods: This is a retrospective study of the case records of patients diagnosed with epithelial ovarian cancer from January 2012 to December 2014.Results: Malignantovarian tumors constituted 5.6% of all malignancies in women. 84 cases were of epithelial origin constituting 64.4% of all malignant ovarian tumors. 58% of patients were from Karnataka and 25% were from West Bengal. 27% underwent suboptimal surgery outside at presentation. The median age at presentation was 51 years. Most of the patients were parous (25% were para 2 and 3). 5% patients were nulliparous. Pain abdomen (39%) and abdominal distension/ bloating (16%) were the most common symptoms. 75% of these cases presented in III-IV stage. Method of diagnosis was: primary surgery and Biopsy of mass (50%), fine needle aspiration cytology of mass or ascites/ pleural effusion (40%), and diagnostic laparoscopy in (9.5%) of the patients. The most common histological variants were serous cystadenocarcinoma (32%) and mucinous adenocarcinoma (15%).Conclusions: Majority of the patients presented with vague nonspecific abdominal complaints which leads to delay in diagnosis. Most of the patients presented in advanced stage of the disease. Delay in diagnosis and improper management prior to registering in tertiary cancer centre was common. There is a need to improve awareness regarding ovarian cancer in general population and also primary care physician

Insilico Analysis of RHES Protein for Huntington's Disease

There are numerous subfields within tree science, including biotechnology, zoology, and botany. One of the newest developments in science is the discipline of bioinformatics, which is one of the fields that is booming right now. The multidisciplinary field of bioinformatics creates and enhances techniques for biological data storage, analysis, and interpretation. It solves biological problems, typically at the molecular level, by combining biology, computer science, microbiology, mathematics, statistics, and biochemistry. There are several uses for bioinformatics, including drug design, sequence alignment, gene expression detection, and gene discovery. Modelling is one of the main fields in which bioinformatics is applied. In the scientific field of computational biology, biological data is utilised to create algorithms. In order to better understand biology and the relationships between macromolecules, it also entails the development of mathematical modelling and computational simulation techniques.&nbsp; The mastermind behind the creation of numerous bioinformatics tools is the computational biologist. They created a number of algorithms for the development of software and tools. There are currently over 2,300,000 sequences available. However, its structure isn't accessible. With only 79000 structures now accessible, it is evident that predicting protein structures is a challenging task.&nbsp; A variety of techniques, including homology modelling, threading, and abinitio structure prediction, are available for predicting protein structures. However, determining which approach is more accurate for predicting structure is extremely challenging, even if there are several modelling tools available, like Phyre, Swiss model, and I-tasser. The goal of this study is to predict a novel protein structure and then use the server ProQ to assess the tool's quality. &nbsp

BIOMASS AND NUTRIENT ACCUMULATION OF AN EARLY SUCCESSIONAL SHRUB SPECIES (Zizyphus oenoplia) IN AN UPROOTED RUBBER FIELD AT KAMBURUPITIYA

Restoration of degraded ecosystems has become a matter of great concern. Earlysuccessional species playa key roll in the process of restoration. Therefore here astudy was undertaken to assess the accumulation and partitioning of biomass andnutrient in widely occurring early successional shrub species, namely Zizyphusoenoplia (Eraminiya) of varying ages (i.e. 4, 6 and 8 years). The experiment wasconducted at the faculty of Agriculture, University of Ruhuna, Mupalana,Karnburupitiya, during March-August, 2000. Here, four plots were selected foreach age class and four plants were sampled for each plot and their distribution ofdry matter and major nitrient (NPK) in stem, branches and leaves were measuredin each plant.Findings clearly indicate that majority of biomass was concentrated in plant stemand as the age progressed, this proportion is increased. These results furtherindicate that the biomass allocation to the leaves was high in young ages and it isdecreasing as the age progressed. Total biomass of plant after 4, 6 and 8 yearswas 902, 2602 and 4552 g respectively.Results also show that major nutrient content in leaves, branches and stem werehigh in early stages of the growth and decreasing as the age progressed.Percentage of N. P and K in leaves at 4 years were 2.91, 0.116 and 1.54respectively. But after 8 years N. P and K content were 2.36, 0.093 nd 1.275%respectively, show a decreasing rend of concentration of major nutrient in leaftissues. Stem and branches show the same pattern of nutrient partitioning as theplant getting matured.

SOIL CHARACTERISTICS IN SOME HUMAN IMPACTED AREAS AT KAMBURUPITIYA FOLLOWING THE NILWALA PROJECT

The study involved characterization of physical, chemical, and biologicalproperties of a severely disturbed soil in Kamburupitiya, which has beenpreviously maintained under agroforestry.The bulk density, true density, and porosity of the soil were l.163 gcrrr', 2.14gcrrr' and 45.6% respectively, with a water holding capacity of 28.5%. The percent organic matter and N in the soil were 0.451 and 0.0088, respectively,whereas the corresponding values in an undisturbed neighboring site, were 1,214and and 0.095. The cation exchange capacity of the degraded soil was 4.71 m.e.per 100g. of soil and had a H value of 4.2. The corresponding figures for thereference site were 7.4 and 5.43, respectively. Biological activity of the soil asmeasured by soil respirometry, amounted to 0.716 mg COilOOOg of soil/hr andl.355 mg CO2/lOOOg. of soil/hr in disturbed and undisturbed soil, respectively.No macro fauna was evident in the soil. Even after 12 years of disturbance, soilregeneration was extremely slow, thus agronomic interventions prove important toaccelerate the soil restoration process

STUDIES ON DORMANCY AND GERMINATION DYNAMICS OF Macaranga peltata(KANDA), AN EARLY SUCCESSIONAL SPECIES

Macaranga peltata is one of the most widely occurring early successional woodyspecies, specially in low country wet zone. Although Macaranga spreadsprofusely by seeds, the seed biology and germination behavior has not beenstudied. According to the preliminary studies, it was revealed that, thegerminability of freshly isolated seeds is very low. Therefore this work wasundertaken to understand the germination behavior and measures to enhance seedgermination of Macaranga. The study was conducted during May-July, 2000, atthe faculty of Agriculture, University of Ruhuna, Mapalana, kamburupitiya, SriLanka.Three treatments used, i.e. mechanical scarification using sand papers (T I),Chemical scarification using H2S04 acid (T2) and hormone treatment using GA(T3)' with the control. Fully ripened seeds were harvested and thoroughly washedto remove the peel and air-dried for one day. Dried seeds were treated asindicated above and placed in petri dishes containing sand media and allowed togerminate. Three replications were used for each treatment and percentage ofgermination was recorded at 7,14,21 and 28 days after planting.Germination of Macaranga seeds started after 14-21 days in control by afterseven days in treated seeds. Mechanical and chemical scarifications were noteffecting in increasing the percentage of germination significantly. But thegibberelic acid treatment has made a tremendous important in the percentage ofgermination and at the same time resulted in significant reduction it time taken forgermination. Although scarification treatments may have improved permeabilityof seed coat, it has not contributed to the germinability of seeds, the significantimpact made by GA treatment both in increasing and accelerating the germinationprobably reveals that there exists a dormancy in Macaranga seeds which is ofphysiological or metabolic in nature GA treatment of more effectively at higherconcentration: (20mm) was capable of breaking the dormancy and thus enhancedgermination.