102 research outputs found
Application of a matrix of BKG in an assessment of a market line item of the company
Β© Medwell Journals, 2017. In study development of approach to carrying out the portfolio analysis in an assessment of a market line item of the company allowing to expand analytical ensuring adoption of strategic decisions for the account of an external environment of the company reveals. Development of the portfolio analysis was carried out from a line item of a priority of strategic reference points of management as necessary condition of implementation of effective production business activities of the entities in modern conditions. Application of the portfolio analysis assumes an assessment and the analysis of external and internal environment of the entity and also use of analytical methods in implementation process of strategy in single system of indicators that is necessary in case of adoption of the strategic decision and touches on issues of integration of traditional methods of management into single process of strategic management. Matrix of BKG (BCG Matrix) the tool of the strategic portfolio analysis of a market position of goods, the companies and divisions proceeding from their market growth and the occupied share in the market. Such tool as a matrix of BKG finds broad application both in management and in marketing and in other spheres of economy now (and not only)
6 forecasting production performance
This article considers the application of econometric calculations by the method of statistical dependence equations to analyze the relationships between various factors and the performance indicator. It is noted that the use of econometric calculations should be based on knowledge and understanding of the essence of economic processes and phenomena, the specifics of economic interrelations and the laws of their development. The study presents the methodology by using statistical dependence equations and calculating the factor stability coefficients based on the actual development indicators of the livestock sector in the Akmola region over several years.peer-reviewe
The efficiency of the russian economy and multidimensional modeling
Β© Medwell Journals, 2016.The study presents the methods and results of a multidimensional assessment of the efficiency of the Russian economy which is based on the interrelationship between the crucial socio-demographic, market and financial-investment proportions of the economy. The researcher construes the efficiency of a macroeconomic system as a state of being close to the "ideal" functioning of the macro-system, attaining strategic objectives and long-run development priorities for the innovative modernization and social capital of the economy, the availability of efficient mechanisms for competition, sustained minimization of corruption and formation of efficient market establishments. The results obtained enabled the researcher to come up with a set of activities aimed at bringing the level of socio-economic efficiency of the Russian economy in line with that of the developed countries of the world
The role of Pnut and its functional domains in Drosophila spermatogenesis
Drosophila Pnut protein belongs to the familyΒ of septins, conservative GTPases participatingΒ in cytokinesis and many more other fundamentalΒ cellular processes. Because of their filamentousΒ appearance, membrane association and functions,Β septins are considered as the fourth componentΒ of the cytoskeleton, along with actin, microtubules andΒ intermediate filaments. However, septins are much lessΒ studied than the other cytoskeleton elements. We hadΒ previously demonstrated that deletion of the peanutΒ (pnut) gene leads to mitotic abnormalities in somaticΒ cells. The goal of this work was to study the roleΒ of pnut in Drosophila spermatogenesis. We designedΒ a construct for pnut RNA interference allowingΒ pnut expression to be suppressed ectopically.Β We analyzed the effect of pnut RNA interferenceΒ on Drosophila spermatogenesis. The most sensitiveΒ to Pnut depletion were germ line cells at the earliestΒ stages of spermatogenesis: the suppression of pnutΒ expression at these stages leads to male sterility asΒ a result of immotile sperm. Testes of those sterileΒ males did not show any significant meiotic defects;Β axonemes and mitochondria were normal. We alsoΒ analyzed the effect of mutations in Pnut conservativeΒ domains on Drosophila spermatogenesis. MutationsΒ in the GTPase domain resulted in cyst elongationΒ defects. Deletions of the C-terminal domain led toΒ abnormal testis morphology. Both GTPase domainΒ and C-terminal domain mutant males were sterile andΒ produced immotile sperm. To summarize, we showedΒ that Pnut participates in spermiogenesis, that is, lateΒ stages of spermatogenesis, when major morphologicalΒ changes in spermatocytes occur
Flood management measures in Russian far easten federal district
The article examines the case that occurred in the Far Eastern Federal District in 2013, and the measures taken to eliminate the flood. In 2013, the south of the Far East was subject to heavy precipitation, which led to a significant rise in the water level in the rivers and to a flood situationΠ ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΡΠ»ΡΡΠ°ΠΉ, ΠΏΡΠΎΠΈΠ·ΠΎΡΠ΅Π΄ΡΠΈΠΉ Π² ΠΠ°Π»ΡΠ½Π΅Π²ΠΎΡΡΠΎΡΠ½ΠΎΠΌ ΡΠ΅Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠΌ ΠΎΠΊΡΡΠ³Π΅ Π² 2013 Π³ΠΎΠ΄Ρ, ΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΠ΅ ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΡ ΠΏΠΎ Π»ΠΈΠΊΠ²ΠΈΠ΄Π°ΡΠΈΠΈ Π½Π°Π²ΠΎΠ΄Π½Π΅Π½ΠΈΡ. Π 2013 Π³ΠΎΠ΄Ρ ΡΠ³ ΠΠ°Π»ΡΠ½Π΅Π³ΠΎ ΠΠΎΡΡΠΎΠΊΠ° Π±ΡΠ» ΠΏΠΎΠ΄Π²Π΅ΡΠΆΠ΅Π½ ΠΎΠ±ΠΈΠ»ΡΠ½ΡΠΌ ΠΎΡΠ°Π΄ΠΊΠ°ΠΌ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΡΠΈΠ²Π΅Π»ΠΈ ΠΊ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΌΡ ΠΏΠΎΠ΄Π½ΡΡΠΈΡ ΡΡΠΎΠ²Π½Ρ Π²ΠΎΠ΄Ρ Π² ΡΠ΅ΠΊΠ°Ρ
ΠΈ ΠΊ ΠΏΠ°Π²ΠΎΠ΄ΠΊΠΎΠ²ΠΎΠΉ ΡΠΈΡΡΠ°ΡΠΈ
Biomedical applications of scanning probe microscopy
ΠΡΠΈΠ²Π΅Π΄Π΅Π½ ΠΎΠ±Π·ΠΎΡ Π΄ΠΎΡΡΠΈΠΆΠ΅Π½ΠΈΠΉ ΡΠΊΠ°Π½ΠΈΡΡΡΡΠ΅ΠΉ Π·ΠΎΠ½Π΄ΠΎΠ²ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠΈ Π² ΡΠ΅ΡΠ΅Π½ΠΈΠΈ Π·Π°Π΄Π°Ρ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ. Π‘ΡΠ΅Π΄ΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎ ΡΠ°Π·Π²ΠΈΠ²Π°ΡΡΠΈΡ
ΡΡ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΉ β ΡΠΎΠ·Π΄Π°Π½ΠΈΠ΅ Π²ΡΡΠΎΠΊΠΎΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² Π΄Π»Ρ ΡΠ°Π½Π½Π΅Π³ΠΎ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠΈΡΠ΅Π½Π΅ΠΉ (Π±Π΅Π»ΠΊΠΎΠ², Π°Π½ΡΠΈΠ³Π΅Π½ΠΎΠ² ΠΈ Π°Π½ΡΠΈΡΠ΅Π», Π²ΠΈΡΡΡΠΎΠ², Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ ΠΈ Π΄Ρ.), Π΄Π»Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΠΈ Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ.The review of the achievements of scanning probe microscopy in solving practical medicine problems is given. Among the actively developing areas is the creation of highly effective methods for the early detection of biological targets (proteins, antigens and antibodies, viruses, bacteria, etc.), for molecular-cell and genetic diagnostics
Research of physico-chemical properties of oral fluid after the transmitted coronaviral infection
The article presents a comparative analysis of the physico-chemical properties of oral fluid: pH, base buffer capacity and surface tension in comparison of oral fluid values in patients who have had a coronavirus infection (group 1) and in healthy people who do not have a history of SARS-CoV-19 infection (group 2). Biological fluid was collected twice from each subject β before and after irrigation of the oral cavity with liquid peptide. In the course of the work, it was revealed that the compensatory mechanisms of the body after the disease are able to restore the homeostasis of the oral cavity and preserve the physic-chemical properties of oral fluid. The effect of the peptide did not change the studied parameters.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡΡ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ² ΡΠΎΡΠΎΠ²ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠΈ: pH, Π±ΡΡΠ΅ΡΠ½Π°Ρ ΡΠΌΠΊΠΎΡΡΡ ΠΏΠΎ ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠ½ΠΎΠ΅ Π½Π°ΡΡΠΆΠ΅Π½ΠΈΠ΅ Π² ΡΡΠ°Π²Π½Π΅Π½ΠΈΠΈ Π·Π½Π°ΡΠ΅Π½ΠΈΠΉ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΡΠΎΡΠΎΠ²ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΠ΅ΡΠ΅Π½ΡΡΡΠΈΡ
ΠΊΠΎΡΠΎΠ½Π°Π²ΠΈΡΡΡΠ½ΡΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΡ (1 Π³ΡΡΠΏΠΏΠ°) ΠΈ Ρ Π·Π΄ΠΎΡΠΎΠ²ΡΡ
Π»ΡΠ΄Π΅ΠΉ, Π½Π΅ ΠΈΠΌΠ΅ΡΡΠΈΡ
Π² Π°Π½Π°ΠΌΠ½Π΅Π·Π΅ ΠΆΠΈΠ·Π½ΠΈ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΡ SARS-CoV-19 (2 Π³ΡΡΠΏΠΏΠ°). ΠΠ°Π±ΠΎΡ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠΈ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΡΡ Π΄Π²Π°ΠΆΠ΄Ρ Ρ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΠΎΠ³ΠΎ β Π΄ΠΎ ΠΎΡΠΎΡΠ΅Π½ΠΈΡ ΡΠΎΡΠΎΠ²ΠΎΠΉ ΠΏΠΎΠ»ΠΎΡΡΠΈ ΠΆΠΈΠ΄ΠΊΠΈΠΌ ΠΏΠ΅ΠΏΡΠΈΠ΄ΠΎΠΌ ΠΈ ΠΏΠΎΡΠ»Π΅. Π Ρ
ΠΎΠ΄Π΅ ΡΠ°Π±ΠΎΡΡ ΡΠ΄Π°Π»ΠΎΡΡ Π²ΡΡΠ²ΠΈΡΡ, ΡΡΠΎ ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠ°ΡΠΎΡΠ½ΡΠ΅ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ° ΠΏΠΎΡΠ»Π΅ ΠΏΠ΅ΡΠ΅Π½Π΅ΡΠ΅Π½Π½ΠΎΠ³ΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΡΠΏΠΎΡΠΎΠ±Π½Ρ Π²ΠΎΡΡΡΠ°Π½Π°Π²Π»ΠΈΠ²Π°ΡΡ Π³ΠΎΠΌΠ΅ΠΎΡΡΠ°Π· ΡΠΎΡΠΎΠ²ΠΎΠΉ ΠΏΠΎΠ»ΠΎΡΡΠΈ ΠΈ ΡΠΎΡ
ΡΠ°Π½ΡΡΡ ΡΠΈΠ·ΠΈΠΊΠΎ-Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΡΠΎΡΠΎΠ²ΠΎΠΉ ΠΆΠΈΠ΄ΠΊΠΎΡΡΠΈ. ΠΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΏΠ΅ΠΏΡΠΈΠ΄Π° Π½Π΅ ΠΈΠ·ΠΌΠ΅Π½ΠΈΠ»ΠΎ ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ
Euthanasia as lusted killing
The article deals with the problems of legalization of euthanasia in the Russian Federation, as well as legal, economic, religious and medical aspects of this topic.Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ Π»Π΅Π³Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΡΠ²ΡΠ°Π½Π°Π·ΠΈΠΈ Π² Π ΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ Π€Π΅Π΄Π΅ΡΠ°ΡΠΈΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠ°Π²ΠΎΠ²ΡΠ΅, ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΠ΅, ΡΠ΅Π»ΠΈΠ³ΠΈΠΎΠ·Π½ΡΠ΅ ΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΠ΅ Π°ΡΠΏΠ΅ΠΊΡΡ Π΄Π°Π½Π½ΠΎΠΉ ΡΠ΅ΠΌΡ
ο»ΏAmplicon metagenomics of dung beetles (Coleoptera, Scarabaeidae, Scarabaeinae) as a proxy for lemur (Primates, Lemuroidea) studies in Madagascar
Dung beetles (Scarabaeidae, Scarabaeinae) are among the most cost-effective and informative biodiversity indicator groups, conveying rich information about the status of habitats and faunas of an area. Yet their use for monitoring the mammal species, that are the main providers of the food for the dung beetles, has only recently been recognized. In the present work, we studied the diet of four endemic Madagascan dung beetles (Helictopleurus fissicollis (Fairmaire), H. giganteus (Harold), Nanos agaboides (Boucomont), and Epilissus splendidus Fairmaire) using high-throughput sequencing and amplicon metagenomics. For all beetle species, the β
βΒΎ of reads belonged to humans, suggesting that human feces are the main source of food for the beetles in the examined areas. The second most abundant were the reads of the cattle (Bos taurus Linnaeus). We also found lower but significant number of reads of six lemur species belonging to three genera. Our sampling localities agree well with the known ranges of these lemur species. The amplicon metagenomics method proved a promising tool for the lemur inventories in Madagascar
- β¦