A Comparative Analysis of Three Major Transfer Airports in Northeast Asia Focusing on Incheon International Airport Using a Conjoint Analysis

Due mainly to the privatization and commercialization of airline companies and deregulation of the aviation rules, the demand for air transport has continuously been increasing. Airport authorities state that transfer passengers, who contribute to the large portion of the airports’ profits, are gaining much more importance, particularly in the Northeast Asia region where the air transport industry is very vital. Therefore, this study aims to investigate the competitiveness of IIA (Incheon International Airport) with other major airports located in Northeast Asia in passenger transfers made between Southeast Asia and China to North America using Conjoint Analysis. Results have indicated that airport brand is the most important attribute for the competitiveness of airport, followed by cost, connectivity and duty free shops. In further analysis focusing on brand value of the three airports measured by the use of transfer passengers, it was revealed that IIA needs more effort in developing their brand identity to become the leading transfer hub airport. Based on the results, recommendations for increasing the brand value have also been suggested

The role of small bowel endoscopy in small bowel Crohn's disease: when and how?

Endoscopy has a crucial role in the diagnosis, management, and surveillance of inflammatory bowel disease (IBD). It contributes in supporting the diagnosis of IBD with the clinical history, physical examination, laboratory findings, and targeted biopsies. Furthermore, endoscopy has a significant role in assessing disease activity and distribution in treatment efficacy evaluation, post-surgical recurrence risk, and cancer surveillance in patients with long-lasting illness. Endoscopy also provides therapeutic potential for the treatment of IBD, especially with stricture dilatation and treatment of bleeding. Small bowel (SB) endoscopy (capsule endoscopy and device-assisted enteroscopy) and cross-sectional radiologic imaging (computed tomography enterography and magnetic resonance enterography) have become important diagnostic options to diagnose and treat patients with SB Crohn's disease. We reviewed the present role of SB endoscopy in patients with SB Crohn's disease

The Effects of Cognitive Appraisal and Emotion on Consumer Behavior: The Critical Role of Recollection in the Luxury Cruise Setting

Abstract de la ponencia[EN] The purposes of this study were: (1) to integrate the cognitive appraisal theory and script theory; (2) to examine the bonding character of recollection; and (3) to assess the relationships between consumers ‘appraisals, positive/negative emotions, recollection, storytelling and repurchase intention. A review of previous studies revealed 14 theoretical hypotheses. The proposed hypotheses were tested utilizing data collected from 300 luxury cruise passengers. Confirmatory factor analysis and structural equation modeling were utilized to test the proposed theoretical relationships. According to the results, this work was the first to integrate the cognitive appraisal approach and script theory and also depicted a new angle from which marketers can better understand cruise travelers’ behaviorJoo, E.; Shin, H.; Kim, I.; Choi, J.; Jang, J.; Hyun, S. (2016). The Effects of Cognitive Appraisal and Emotion on Consumer Behavior: The Critical Role of Recollection in the Luxury Cruise Setting. En CARMA 2016: 1st International Conference on Advanced Research Methods in Analytics. Editorial Universitat Politècnica de València. 167-167. https://doi.org/10.4995/CARMA2016.2015.3135OCS16716

Enhancing photoluminescence quantum efficiency of metal halide perovskites by examining luminescence-limiting factors

Metal halide perovskites (MHPs) show superior optoelectronic properties, which give them the great potential for use in next generation light-emitting diodes (LEDs). In particular, their narrow emission linewidths can achieve ultrahigh color purity. However, the reported luminescence efficiency (LE) values are not high enough to be commercialized in displays and solid-state lightings. Moreover, the operational stability of LEDs associated with the overshooting of luminance and the high relative standard deviation of reported external quantum efficiencies are still problematic. In this perspective, we review photophysical factors that limit the photoluminescence quantum efficiency of perovskite-based LEDs. These factors are categorized into (i) weak exciton binding, (ii) nonradiative recombinations, (iii) slow cooling of long-lived hot carriers, (iv) deep-level defects, and (v) interband transition rates. We then present various physicochemical methods to effectively overcome these luminescence-limiting factors. We finally suggest some useful research directions to further improve the LE of MHP emitters as core components in displays and solid-state lightings.

Anti-diabetic effect of Cyclo-His-Pro (CHP)-enriched yeast hydrolysate in streptozotocin-induced diabetic mice

The present study was designed to investigate the hypoglycemic effects of the daily oral dose of 0.50 to 0.75 g/kg of yeast hydrolysate (YH) containing high Cyclo-His-Pro (51.0 mg CHP/g YH) on normal and streptozotocin (STZ)-induced diabetic rats for 14 days. In STZ-induced diabetic rats, after administrations of the YH for 14 days, the body weight gain was significantly increased in dose dependent manner, and the plasma glucose levels were decreased approximately (60%) as compared to the STZ induced diabetic control group. Glucose level showed significant differences between the diabetic control (DC) and the YH administered groups in oral glucose tolerance test (OGTT) (P<0.05). Results of the OGTT showed a significant decrease in the area under curve (AUC) value of YH supplemented groups as compared to the DC group. The present data suggests that the CHP-enriched YH has potential anti-diabetic effect, which can help in the cure and management of diabetes.Keywords: Yeast hydrolysate, Cyclo-His-Pro (CHP), diabetes, streptozotocin.African Journal of Biotechnology Vol. 12(35), pp. 5473-547

Temperature-insensitive flexible polymer wavelength filter fabricated on polymer substrates

Temperature-insensitive polymer wavelength filters with silicon nitride gratings were fabricated on a polymer substrate. Polymer waveguides on polymer substrates were fabricated on top of the Si wafer with a water soluble poly(vinylalcohol) (PVA) interlayer between the Si wafer and polymer waveguides. After the completion of the waveguides, the polymer waveguides are separated from the substrate by dissolving the PVA layer to form all polymer waveguides. The novel process provides a way to overcome the problem of the thermal instability of polymer substrate when the polymer waveguides are directly fabricated on polymer substrates. The polymeric wavelength filter fabricated on a polymer substrate exhibits one order of magnitude lower Bragg wavelength shift with temperature than the device on the Si-wafer in the temperature range of 25–70 °C, which is consistent with theoretical prediction.The authors thank the KOSET through CRM for financial support of this work

Prolonged Activation of ERK Contributes to the Photorejuvenation Effect in Photodynamic Therapy in Human Dermal Fibroblasts

Photodynamic therapy (PDT) is known to be effective in the photorejuvenation of photoaged skin. However, the molecular mechanisms of rejuvenation by PDT remain elusive. In this study, we aimed to understand the molecular events occurring during the photorejuvenation after PDT in dermal fibroblasts in vitro. First, we found that PDT conditions resulted in an increased fibroblast proliferation and motility in vitro. Under this condition, cells had increased intracellular reactive oxygen species (ROS) production. Importantly, PDT induced a prolonged activation of extracellular signal–regulated kinase (ERK) with a corresponding increase in matrix metalloproteinase (MMP)-3 and collagen type Iα messenger RNA and protein. Moreover, inhibition of PDT-induced ERK activation significantly suppressed fibroblast proliferation and expression of MMP-3 and collagen type Iα following PDT. In addition, NAC (an antioxidant) inhibited PDT-induced fibroblast proliferation and ERK activation indicating that prolonged ERK activation and intracellular ROS contribute to the proliferation of fibroblasts and the dermal remodeling process for skin rejuvenation. We also identified increased collagen volume and decreased elastotic materials that are used as markers of photoaging in human skin samples using histochemical studies. Results from this study suggest that intracellular ROS stimulated by PDT in dermal fibroblasts lead to prolonged activation of ERK and, eventually, fibroblast proliferation and activation. Our data thus reveal a molecular mechanism underlying the skin rejuvenation effect of PDT

Synergistic Effects of Simvastatin and Irinotecan against Colon Cancer Cells with or without Irinotecan Resistance

Aims. We here investigated whether the combination of simvastatin and irinotecan could induce the synergistic effect on colon cancer cells with or without resistance to irinotecan. Methods. We investigated cell proliferation assay and assessed cell death detection ELISA and caspase-3 activity assay of various concentrations of simvastatin and irinotecan to evaluate the efficacy of drug combination on colon cancer cells with or without irinotecan resistance. Results. The IC50 values of simvastatin alone and irinotecan alone were 115.4±0.14 μM (r=0.98) and 62.5±0.18 μM (r=0.98) in HT-29 cells without resistance to irinotecan. The IC50 values of these two drugs were 221.9±0.22 μM (r=0.98) and 195.9±0.16 μM (r=0.99), respectively, in HT-29 cell with resistance to irinotecan. The results of combinations of the various concentrations of two drugs showed that combined treatment with irinotecan and simvastatin more efficiently suppressed cell proliferation of HT-29 cells even with resistance to irinotecan as well as without resistance. Furthermore, the combination of simvastatin and irinotecan at 2:1 molar ratio showed the best synergistic interaction. Conclusion. Simvastatin could act synergistically with irinotecan to overcome irinotecan resistance of colon cancer

Purification and proteomic identification of putative upstream regulators of polo-like kinase-1 from mitotic cell extracts

AbstractPolo-like kinase-1 (Plk1) is phosphorylated on Thr210 for activation during mitosis. Here, we investigated the question of which kinase(s) is the specific upstream kinase of mitotic Plk1. Upstream kinases of Plk1 were purified from mitotic cell extracts through column chromatography procedures, and identified by mass spectrometry. Candidates for Plk1 kinase included p21-activated kinase, aurora A, and mammalian Ste20-like kinases. Immunoprecipitates of these proteins from mitotic cell extracts phosphorylated Plk1 on Thr210. Even if the activity of Aurora A was blocked with a specific inhibitor, Plk1 phosphorylation still occurred, suggesting that function of Plk1 could be controlled by these kinases for proper mitotic progression, as well as by Aurora A in very late G2 phase for the beginning of mitosis.Structured abstractMINT-7996332: PAK1(uniprotkb:Q13153)physically interacts(MI:0915) withPLK1(uniprotkb:P53350) bypull down(MI:0096)MINT-7996345: PAK3(uniprotkb:O75914)physically interacts(MI:0915) withPLK1(uniprotkb:P53350) bypull down(MI:0096