Regulating the Unregulated: The Beginning of the End of a Laissez-Faire Era of the Crypto WIld West

The crypto market has been left largely unregulated on a global scale for over a decade. 1 Recently, multiple jurisdictions are aligning efforts to tame the increasingly volatile crypto “Wild West” as evidenced by the influx of forthcoming legislations, consultations between operators and regulators, and regulatory crackdowns. 2 A cross-comparative analysis of the regulatory framework in the United States, the European Union, and Korea indicates that the proposed scopes of legislations cover an expansive breadth of assets. However, there are further needs for supplementary regulations following the enactment of the newly proposed regulations to close certain critical gaps that remain unaddressed as well as elucidating the scope of application with respect to ancillary and incidental actors in the industry. Moreover, this piece notes that while cross-border and cross-sector crypto transactions require a globally coordinated enforcement scheme, regulatory initiatives should concurrently reflect the unique business and regulatory climates and practices of each jurisdiction

Ixeris dentata (Thunb) Nakai Ethylacetate Extract Attenuates Sterol Regulatory Element-Binding Proteins-1c via AMP-Activated Protein Kinase Activation

Purpose: To investigate the molecular mechanisms underlying the role of Ixeris dentataa extract (IDE) in the prevention of high glucose induced lipid accumulation in human HepG-2 hepatocytes.Methods: IDE extract was prepared by maceration in ethyl acetate. Its fractionation was carried out by column chromatography. HepG-2 cells were pretreated with various concentration of IDE (0, 10, 20, 40 and 80 μg/mL) and then treated with serum-free medium with normal glucose (5 mM) for 1 h, followed by exposure to high glucose (30 mM D-glucose) for 24 h. Cell viability and cytotoxicity parameters were measured using lactate dehydrogenase (LDH) and MTT assay while triglyceride and total cholesterol levels were evaluated using respective enzymatic reagent kits. Protein expressional levels were analyzed by Western blotting.Results: IDE did not influence the cell viability (up to 200 μg/mL) and did not show any signs of cytotoxicity (up to 80 μg/mlL. IDE significantly attenuated lipid accumulation in human HepG2 hepatocytes when exposed to high glucose (30 mM D-glucose) in a dose-dependent manner (p < 0.05, 0.01 and 0.001 at 20, 40 and 80 μg/mL concentrations, respectively). Nile red staining showed that 10, 20, 40 and 80 μg/mL concentrations of IDE reduced lipid accumulation by 23.4, 34.8 (p < 0.05), 46.5 (p < 0.01) and 53.2 % (p < 0.001), respectively. The increased levels of triglycerides and total cholesterol were also attenuated by IDE (p < 0.001 at 80 μg/mL). Further, IDE attenuated the expression of fatty acid synthase and sterol regulatory element-binding protein-1. Adenosine monophosphate-activated protein kinase was also activated by IDE treatment when exposed to high glucose level (30 mM Dglucose) in human HepG2 hepatocytes.Conclusion: The findings indicate that IDE exerts hypolipidemic effect by inhibiting lipid biosynthesis, mediated via AMPK signaling. This probably explains the extract’s beneficial effect in various inflammation disorders.Keywords: Ixeris dentata extract, Lipogenesis, AMP-activated protein kinase, Sterol regulatory element-binding protein 1 -1, Anti-obesity, HepG-2 cel

In Vitro Chemosensitivity Using the Histoculture Drug Response Assay in Human Epithelial Ovarian Cancer

The choice of chemotherapeutic drugs to treat patients with epithelial ovarian cancer has not depended on individual patient characteristics. We have investigated the correlation between in vitro chemosensitivity, as determined by the histoculture drug response assay (HDRA), and clinical responses in epithelial ovarian cancer. Fresh tissue samples were obtained from 79 patients with epithelial ovarian cancer. The sensitivity of these samples to 11 chemotherapeutic agents was tested using the HDRA method according to established methods, and we analyzed the results retrospectively. HDRA showed that they were more chemosensitive to carboplatin, topotecan and belotecan, with inhibition rates of 49.2%, 44.7%, and 39.7%, respectively, than to cisplatin, the traditional drug of choice in epithelial ovarian cancer. Among the 37 patients with FIGO stage Ⅲ/Ⅳ serous adenocarcinoma who were receiving carboplatin combined with paclitaxel, those with carboplatin-sensitive samples on HDRA had a significantly longer median disease-free interval than patients with carboplatin- resistant samples (23.2 vs. 13.8 months, p＜0.05), but median overall survival did not differ significantly (60.4 vs. 37.3 months, p＝0.621). In conclusion, this study indicates that HDRA could provide useful information for designing individual treatment strategies in patients with epithelial ovarian cancer

Linear-Gompertz Model-Based Regression of Photovoltaic Power Generation by Satellite Imagery-Based Solar Irradiance

A simple yet accurate photovoltaic (PV) performance curve as a function of satellite-based solar irradiation is necessary to develop a PV power forecasting model that can cover all of South Korea, where more than 35,000 PV power plants are currently in operation. In order to express the nonlinear power output of the PV module with respect to the hourly global horizontal irradiance derived from satellite images, this study employed the Gompertz model, which is composed of three parameters and the sigmoid equation. The nonphysical behavior of the Gompertz model within the low solar irradiation range was corrected by combining a linear equation with the same gradient at the conjoint point. The overall fitness of Linear-Gompertz regression to the 242 PV power plants representing the country was R2 = 0.85 and nRMSE = 0.09. The Gompertz model coefficients showed normal distributions and equivariance of standard deviations of less than 15% by year and by season. Therefore, it can be conjectured that the Linear-Gompertz model represents the whole country’s PV system performance curve. In addition, the Gompertz coefficient C, which controls the growth rate of the curve, showed a strong correlation with the capacity factor, such that the regression equation for the capacity factor could be derived as a function of the three Gompertz model coefficients with a fitness of R2 = 0.88.This work was conducted under the framework of the Research and Development Program of the Korea Institute of Energy Research (C0-2407)

Pareto Weights in Practice: A Quantitative Analysis across 32 OECD Countries

We develop a quantitative heterogeneous-agents general equilibrium model that reproduces the income inequalities of 32 countries in the Organization for Economic Co-operation and Development. Using this model, we compute the optimal income tax rate for each country under the equal-weight utilitarian social welfare function. We simulate the voting outcome for the utilitarian optimal tax reform for each country. Finally, we uncover the Pareto weights in the social welfare functions of each country that justify the current redistribution policy

Anti-oxidative and anti-neuroinflammatory effects of ethyl acetate extract fractions of Suaeda asparagoides MIq

Purpose: To evaluate the in vitro antioxidant and anti-neuroinflammatory effects of Suaeda asparagoides ethylacetate extract (SAE) in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells.Methods: The antioxidative activity of SAE was evaluated by measuring 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activity  spectrometrometrically. Cell viability was evaluated by 3-(4, 5- dimethylthiazol-2-yl)-2, 5- diphenyl-tetrazolium bromide (MTT) assay, while LPS-stimulated BV-2 microglia were used to study the expression and production of inflammatory mediators, including nitric oxide (NO), inducible NO synthase (iNOS) and tumor necrosis alpha (TNF-α).Results: Pretreatment with SAE prior to LPS treatment significantly inhibited excessive production of NO (p < 0.001 at 20, 40, 80 and 100 μg/mL) in a dose-dependent manner, and was associated with down-regulation of expression of inducible nitric oxide synthase (iNOS). SAE also suppressed the LPSinduced increase in TNF-α level (p < 0.01at concentrations of 40 and 80 μg/mL) in BV-2 cells. Furthermore, DPPH-generated free radicals were inhibited by SAE in a concentration-dependent manner.Conclusion: These results indicate that SAE possesses strong anti-oxidant properties, and inhibits excessive production of pro-inflammatory mediators, including NO, iNOS and TNF-α, in LPS-stimulated BV-2 cellsKeywords: Suaeda asparagoides, DPPH, Anti-inflammatory activity, Microglial cells, iNOS, TNF-

Muon g−2g-2 and Proton Lifetime in SUSY SU(5) GUTs with Split Superpartners

We consider the interplay of the muon $g-2$ anomaly and the proton decay in the SUSY SU(5) GUTs with generation-independent scalar soft masses. In these scenarios, we introduce a number of $\bf 5+{\bar 5}$ messenger fields with doublet-triplet splitting in general gauge mediation to transmit SUSY breaking to the visible sector by gauge loops. As a result, squarks and sleptons receive generation-independent soft SUSY breaking masses, which are split already at the messenger scale. Taking into account the perturbative unification of gauge couplings as well as the bounds from electroweak precision and vacuum stability bounds, we showed the parameter space in general gauge mediation to explain the muon $g-2$ anomaly with smuon and sneutrino loops while evading the strong bounds on squarks and gluinos from the Large Hadron Collider. We also obtained the dominant Higgsino contributions to the proton decay mode, $p\to K^+{\bar\nu}$, with general generation-independent sparticle masses for squarks and sleptons. Even for split scalar soft masses in our model, however, we found that the bounds from the proton decay are satisfied only if the effective Yukawa couplings of the colored Higgsinos are suppressed further by a factor of order $10^{-4}-10^{-3}$. We illustrated how such a suppression factor is realized in orbifold GUTs in the extra dimension where the colored Higgsinos in the bulk are not coupled to the matter fields localized at the orbifold fixed points at the leading order.Comment: 35 pages, 8 figures, v2: typos fixed and reference updated, v3: version to appear in Phys. Rev.

A case of successful surgical treatment for peritoneal seeding of hepatocellular carcinoma after radiotherapy and atezolizumab plus bevacizumab combination treatment

Peritoneal seeding of hepatocellular carcinoma (HCC) is incurable and has poor prognosis. A 68-year-old man underwent surgical resection for a 3.5 cm single nodular HCC at the tip of segment 3 and transarterial chemoembolization for a 1.5 cm-sized recurrent HCC at the tip of segment 6. 3 months later, an increasing 1 cm pelvic nodule on the rectovesical pouch warranted radiotherapy. Although it stabilized, a new 2.7 cm-sized peritoneal nodule in the right upper quadrant (RUQ) omentum appeared 3.5 years after radiotherapy. Hence, omental mass and small bowel mesentery mass excision were performed. 3 years later, recurrent peritoneal metastases in the RUQ omentum and rectovesical pouch progressed. 33 cycles of atezolizumab and bevacizumab treatment elicited stable disease response. Finally, laparoscopic left pelvic peritonectomy was performed without tumor recurrence. Herein, we present a case of HCC with peritoneal seeding that was successfully treated with surgery after radiotherapy and systemic therapy, leading to complete remission

Effects of scleral-lens oxygen transmissibility on corneal thickness: A pilot study.

PurposeTo investigate the effect of various oxygen transmissibilities (Dk/t) of scleral lenses and corneal thickness recovery time from overnight eye closure with patching on corneal edema during 5 h lens wear.MethodsScleral lenses (hofocon A, 15.6 mm diameter) were worn bilaterally with three different Dks (100, 140, and 160 Barrer). Central and peripheral corneal thickness (CCT and PCT) were measured using optical coherence tomography. Four subjects were randomly selected for one additional visit and asked to patch one eye before night sleeping. The patch was not removed until lens insertion to avoid corneal deswelling. Then CCT of both eyes was measured.ResultsTen neophytes with healthy eyes participated in the study. Mean [95% CI] Dk/t of the study lenses was 32.0 [29.2, 34.7] hBarrer/cm. Mean [95% CI] CCT immediately upon lens insertion and after 5 h of lens wear were 532.4 [520.3, 544.5] μm and 538.7 [526.5, 551.0] μm, respectively. Mean [95% CI] percentage change (%Δ) in CCT was 1.2% [0.9%, 1.5%], 1.2% [0.9%, 1.4%], and 0.8% [0.6%, 1.1%] for CCT, nasal PCT, and temporal PCT, respectively. There was an inverse relationship between temporal Dk/t and %ΔPCT (p < 0.05) while Dk/t was not found significantly associated with either CCT or nasal PCT. The patched eyes maintained a relatively stable CCT and showed progressive deswelling, starting and ending with 2.8% and 0.6%, respectively. In contrast, the unpatched eyes swelled, starting with nearly 0% and ending with 0.7% with a maximum swelling of 1.8%.ConclusionThere was limited amount of corneal edema induced by short-term scleral lens wear with lens Dk/t ranging from 21 to 47 hBarrer/cm and lenses with lower lens Dk/t did not induce significantly higher corneal swelling. Scleral lens insertion soon after overnight eye closure with patching did not introduce additional swelling for young and healthy eyes