Asymptomatic Primary Fallopian Tube Cancer: An Unusual Cause of Axillary Lymphadenopathy

Primary Fallopian tube malignancy is considered a rare disease and is often mistaken histologically and clinically for ovarian cancer. The etiology is poorly understood, and it typically presents at an advanced disease stage, as symptoms are often absent in the initial period. As a result, primary fallopian tube cancer is generally associated with a poor prognosis. We present the case of a 45-year-old female who presents with a 5-day history of left axillary swelling and a normal breast examination. Mammogram and biopsy of a lesion in the left breast revealed a fibroadenoma but no other abnormalities. Initial sampling of the axillary node was suspicious for a primary breast malignancy, but histology of the excised node refuted this. PET-CT showed an area of high uptake in the right pelvis, and a laparoscopy identified a tumor of the left fallopian tube which was subsequently excised and confirmed as a serous adenocarcinoma

The Relationship Between X-ray Luminosity and Duty Cycle for Dwarf Novae and their Specific Frequency in the Inner Galaxy

We measure the duty cycles for an existing sample of well observed, nearby dwarf novae using data from AAVSO, and present a quantitative empirical relation between the duty cycle of dwarf novae outbursts and the X-ray luminosity of the system in quiescence. We have found that $\log DC=0.63(\pm0.21)\times(\log L_{X}({\rm erg\,s^{-1}})-31.3)-0.95(\pm0.1)$, where DC stands for duty cycle. We note that there is intrinsic scatter in this relation greater than what is expected from purely statistical errors. Using the dwarf nova X-ray luminosity functions from \citet{Pretorius12} and \citet{Byckling10}, we compare this relation to the number of dwarf novae in the Galactic Bulge Survey which were identified through optical outbursts during an 8-day long monitoring campaign. We find a specific frequency of X-ray bright ($L_{X}>10^{31}\,{\rm erg\,s^{-1}}$) Cataclysmic Variables undergoing Dwarf Novae outbursts in the direction of the Galactic Bulge of $6.6\pm4.7\times10^{-5}\,M_{\odot}^{-1}$. Such a specific frequency would give a Solar neighborhood space density of long period CVs of $\rho=5.6\pm3.9\times10^{-6}\,$pc$^{-3}$. We advocate the use of specific frequency in future work, given that projects like LSST will detect DNe well outside the distance range over which $\rho\approx{\textrm const}$.Comment: 9 pagers, 4 figures Accepted for publication in MNRA

The massive neutron star or low-mass black hole in 2S0921-630

We report on optical spectroscopy of the eclipsing Halo LMXB 2S0921-630, that reveals the absorption line radial velocity curve of the K0III secondary star with a semi-amplitude K_2=92.89 +/- 3.84 km/s, a systemic velocity $\gamma$=34.9 +/- 3.3 \kms and an orbital period P_orb of 9.0035 +/- 0.0029 day (1-sigma). Given the quality of the data, we find no evidence for the effects of X-ray irradiation. Using the previously determined rotational broadening of the mass donor, and applying conservative limits on the orbital inclination, we constrain the compact object mass to be 2.0-4.3 Msolar (1-sigma), ruling out a canonical neutron star at the 99% level. Since the nature of the compact object is unclear, this mass range implies that the compact object is either a low-mass black hole with a mass slightly higher than the maximum neutron star mass (2.9 Msolar) or a massive neutron star. If the compact object is a black hole, it confirms the prediction of the existence of low-mass black holes, while if the object is a massive neutron star its high mass severely constrains the equation of state of nuclear matter.Comment: Accepted by ApJ

Constraining the nature of the accreting binary in CXOGBS J174623.5-310550

We report optical and infrared observations of the X-ray source CXOGBS J174623.5-310550. This Galactic object was identified as a potential quiescent low-mass X-ray binary accreting from an M-type donor on the basis of optical spectroscopy and the broad Halpha emission line. The analysis of X-shooter spectroscopy covering 3 consecutive nights supports an M2/3-type spectral classification. Neither radial velocity variations nor rotational broadening is detected in the photospheric lines. No periodic variability is found in I- and r'-band light curves. We derive r' = 20.8, I = 19.2 and Ks = 16.6 for the optical and infrared counterparts with the M-type star contributing 90% to the I-band light. We estimate its distance to be 1.3-1.8 kpc. The lack of radial velocity variations implies that the M-type star is not the donor star in the X-ray binary. This could be an interloper or the outer body in a hierarchical triple. We constrain the accreting binary to be a < 2.2 hr orbital period eclipsing cataclysmic variable or a low-mass X-ray binary lying in the foreground of the Galactic Bulge.Comment: (9 pages, 5 figures, accepted for publication in MNRAS

Measuring The Evolutionary Rate Of Cooling Of ZZ Ceti

We have finally measured the evolutionary rate of cooling of the pulsating hydrogen atmosphere (DA) white dwarf ZZ Ceti (Ross 548), as reflected by the drift rate of the 213.13260694 s period. Using 41 yr of time-series photometry from 1970 November to 2012 January, we determine the rate of change of this period with time to be dP/dt = (5.2 +/- 1.4) x 10(-15) s s(-1) employing the O - C method and (5.45 +/- 0.79) x 10(-15) s s(-1) using a direct nonlinear least squares fit to the entire lightcurve. We adopt the dP/dt obtained from the nonlinear least squares program as our final determination, but augment the corresponding uncertainty to a more realistic value, ultimately arriving at the measurement of dP/dt = (5.5 +/- 1.0) x 10(-15) s s(-1). After correcting for proper motion, the evolutionary rate of cooling of ZZ Ceti is computed to be (3.3 +/- 1.1) x 10(-15) s s(-1). This value is consistent within uncertainties with the measurement of (4.19 +/- 0.73) x 10(-15) s s(-1) for another similar pulsating DA white dwarf, G 117-B15A. Measuring the cooling rate of ZZ Ceti helps us refine our stellar structure and evolutionary models, as cooling depends mainly on the core composition and stellar mass. Calibrating white dwarf cooling curves with this measurement will reduce the theoretical uncertainties involved in white dwarf cosmochronometry. Should the 213.13 s period be trapped in the hydrogen envelope, then our determination of its drift rate compared to the expected evolutionary rate suggests an additional source of stellar cooling. Attributing the excess cooling to the emission of axions imposes a constraint on the mass of the hypothetical axion particle.NSF AST-1008734, AST-0909107Norman Hackerman Advanced Research Program 003658-0252-2009Astronom

Interaction of Dendritic Cells with Skin Endothelium: A New Perspective on Immunosurveillance

The goal of this study was to determine the mechanisms by which dendritic cells (DCs) in blood could interact with endothelium, a prerequisite to extravasation into tissues. Our results indicate that DCs express both HECA-452–reactive and nonreactive isoforms of P-selectin glycoprotein ligand 1 (PSGL-1) and can tether and roll efficiently on E- and P-selectin under flow conditions in vitro. Freshly isolated blood DCs were further observed to roll continuously along noninflamed murine dermal endothelium in vivo. This interaction is strictly dependent on endothelial selectins, as shown by experiments with blocking antibodies and with E- and P-selectin–deficient mice. We hypothesize that DCs in blood are constitutively poised at the interface of blood and skin, ready to extravasate upon induction of inflammation, and we showed that cutaneous inflammation results in a rapid recruitment of DCs from the blood to tissues. We propose that this is an important and previously unappreciated element of immunosurveillance

Measuring The Evolutionary Rate Of Cooling Of ZZ Ceti

We have finally measured the evolutionary rate of cooling of the pulsating hydrogen atmosphere (DA) white dwarf ZZ Ceti (Ross 548), as reflected by the drift rate of the 213.13260694 s period. Using 41 yr of time-series photometry from 1970 November to 2012 January, we determine the rate of change of this period with time to be dP/dt = (5.2 +/- 1.4) x 10(-15) s s(-1) employing the O - C method and (5.45 +/- 0.79) x 10(-15) s s(-1) using a direct nonlinear least squares fit to the entire lightcurve. We adopt the dP/dt obtained from the nonlinear least squares program as our final determination, but augment the corresponding uncertainty to a more realistic value, ultimately arriving at the measurement of dP/dt = (5.5 +/- 1.0) x 10(-15) s s(-1). After correcting for proper motion, the evolutionary rate of cooling of ZZ Ceti is computed to be (3.3 +/- 1.1) x 10(-15) s s(-1). This value is consistent within uncertainties with the measurement of (4.19 +/- 0.73) x 10(-15) s s(-1) for another similar pulsating DA white dwarf, G 117-B15A. Measuring the cooling rate of ZZ Ceti helps us refine our stellar structure and evolutionary models, as cooling depends mainly on the core composition and stellar mass. Calibrating white dwarf cooling curves with this measurement will reduce the theoretical uncertainties involved in white dwarf cosmochronometry. Should the 213.13 s period be trapped in the hydrogen envelope, then our determination of its drift rate compared to the expected evolutionary rate suggests an additional source of stellar cooling. Attributing the excess cooling to the emission of axions imposes a constraint on the mass of the hypothetical axion particle.NSF AST-1008734, AST-0909107Norman Hackerman Advanced Research Program 003658-0252-2009Astronom