Searching for Dark Photons with Maverick Top Partners

In this paper, we present a model in which an up-type vector-like quark (VLQ) is charged under a new $U(1)_d$ gauge force which kinetically mixes with the SM hypercharge. The gauge boson of the $U(1)_d$ is the dark photon, $\gamma_d$. Traditional searches for VLQs rely on decays into Standard Model electroweak bosons $W,Z$ or Higgs. However, since no evidence for VLQs has been found at the Large Hadron Collider (LHC), it is imperative to search for other novel signatures of VLQs beyond their traditional decays. As we will show, if the dark photon is much less massive than the Standard Model electroweak sector, $M_{\gamma_d}\ll M_Z$, for the large majority of the allowed parameter space the VLQ predominately decays into the dark photon and the dark Higgs that breaks the $U(1)_d$ . That is, this VLQ is a `maverick top partner' with nontraditional decays. One of the appeals of this scenario is that pair production of the VLQ at the LHC occurs through the strong force and the rate is determined by the gauge structure. Hence, the production of the dark photon at the LHC only depends on the strong force and is largely independent of the small kinetic mixing with hypercharge. This scenario provides a robust framework to search for a light dark sector via searches for heavy colored particles at the LHC.Comment: 40 pages and 11 figure

Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphangiogenesis.

Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent for Kaposi's sarcoma (KS), which is one of the most common HIV-associated neoplasms. The endothelium is the thin layer of squamous cells where vascular blood endothelial cells (BECs) line the interior surface of blood vessels and lymphatic endothelial cells (LECs) are in direct contact with lymphatic vessels. The KS lesions contain a prominent compartment of neoplastic spindle morphology cells that are closely related to LECs. Furthermore, while KSHV can infect both LECs and BECs in vitro, its infection activates genetic programming related to lymphatic endothelial cell fate, suggesting that lymphangiogenic pathways are involved in KSHV infection and malignancy. Here, we report for the first time that viral interferon regulatory factor 3 (vIRF3) is readily detected in over 40% of KS lesions and that vIRF3 functions as a proangiogenic factor, inducing hypersprouting formation and abnormal growth in a LEC-specific manner. Mass spectrometry analysis revealed that vIRF3 interacted with histone deacetylase 5 (HDAC5), which is a signal-responsive regulator for vascular homeostasis. This interaction blocked the phosphorylation-dependent cytosolic translocation of HDAC5 and ultimately altered global gene expression in LECs but not in BECs. Consequently, vIRF3 robustly induced spindle morphology and hypersprouting formation of LECs but not BECs. Finally, KSHV infection led to the hypersprouting formation of LECs, whereas infection with a ΔvIRF3 mutant did not do so. Collectively, our data indicate that vIRF3 alters global gene expression and induces a hypersprouting formation in an HDAC5-binding-dependent and LEC-specific manner, ultimately contributing to KSHV-associated pathogenesis.IMPORTANCE Several lines of evidences indicate that KSHV infection of LECs induces pathological lymphangiogenesis and that the results resemble KS-like spindle morphology. However, the underlying molecular mechanism remains unclear. Here, we demonstrated that KSHV vIRF3 is readily detected in over 40% of various KS lesions and functions as a potent prolymphangiogenic factor by blocking the phosphorylation-dependent cytosolic translocation of HDAC5, which in turn modulates global gene expression in LECs. Consequently, vIRF3-HDAC5 interaction contributes to virus-induced lymphangiogenesis. The results of this study suggest that KSHV vIRF3 plays a crucial role in KSHV-induced malignancy

The Effects of Furnishings and Technology on Pedagogical Agility and Student Engagement Across Flexible Learning Spaces

We explored how furnishings and technology impact pedagogical agility and student engagement across three flexible learning spaces. We collected various data sources from students and faculty teaching in multiple learning spaces, such as focus group interviews with students, faculty responses to reflection prompts, and pre-and post-occupancy surveys with faculty and students. Flexible furniture configuration was found to support various instructional strategies and facilitate interaction between student-student and student-instructor. A writable surface is beneficial to facilitate student engagement during group activities. Digital displays with content sharing capabilities promote collaborative learning. Specific recommendations for learning space designs and faculty development are provided

Common gauge origin of discrete symmetries in observable sector and hidden sector

An extra Abelian gauge symmetry is motivated in many new physics models in both supersymmetric and nonsupersymmetric cases. Such a new gauge symmetry may interact with both the observable sector and the hidden sector. We systematically investigate the most general residual discrete symmetries in both sectors from a common Abelian gauge symmetry. Those discrete symmetries can ensure the stability of the proton and the dark matter candidate. A hidden sector dark matter candidate (lightest U-parity particle or LUP) interacts with the standard model fields through the gauge boson Z', which may selectively couple to quarks or leptons only. We make a comment on the implications of the discrete symmetry and the leptonically coupling dark matter candidate, which has been highlighted recently due to the possibility of the simultaneous explanation of the DAMA and the PAMELA results. We also show how to construct the most general U(1) charges for a given discrete symmetry, and discuss the relation between the U(1) gauge symmetry and R-parity.Comment: Version to appear in JHE

Higgs decays as a window into the dark sector

A light vector boson, Z_d, associated with a "dark sector" U(1)_d gauge group has been introduced to explain certain astrophysical observations as well as low energy laboratory anomalies. In such models, the Higgs boson may decay into X+Z_d, where X=Z, Z_d or \gamma. Here, we provide estimates of those decay rates as functions of the Z_d coupling through either mass-mixing (e.g. via an enlarged Higgs mechanism) or through heavy new fermion loops and examine the implied LHC phenomenology. Our studies focus on the higher m_{Z_d} case, > several GeV, where the rates are potentially measurable at the LHC, for interesting regions of parameter spaces, at a level complementary to low energy experimental searches for the Z_d. We also show how measurement of the Z_d polarization (longitudinal versus transverse) can be used to distinguish the physics underlying these rare decays.Comment: 13 pages, 10 figures. References updated, some slight rewording, and additional discussion added. Version accepted by PR

U(1)' solution to the mu-problem and the proton decay problem in supersymmetry without R-parity

The Minimal Supersymmetric Standard Model (MSSM) is plagued by two major fine-tuning problems: the mu-problem and the proton decay problem. We present a simultaneous solution to both problems within the framework of a U(1)'-extended MSSM (UMSSM), without requiring R-parity conservation. We identify several classes of phenomenologically viable models and provide specific examples of U(1)' charge assignments. Our models generically contain either lepton number violating or baryon number violating renormalizable interactions, whose coexistence is nevertheless automatically forbidden by the new U(1)' gauge symmetry. The U(1)' symmetry also prohibits the potentially dangerous and often ignored higher-dimensional proton decay operators such as QQQL and UUDE which are still allowed by R-parity. Thus, under minimal assumptions, we show that once the mu-problem is solved, the proton is sufficiently stable, even in the presence of a minimum set of exotics fields, as required for anomaly cancellation. Our models provide impetus for pursuing the collider phenomenology of R-parity violation within the UMSSM framework.Comment: Version published in Phys. Rev.

Latino Retail Entrepreneurship in Minnesota: Implications for Extension Educators

Minnesota has become a “new destination” state for Latino migrants in the United States. What has made Latinos in Minnesota successful? In a narrower sense, what has provided them with a route out of poverty and an alternative to unemployment or discrimination in the labor market? Our purpose was to (a) compile characteristics associated with the Latino community and successful Latino-owned retail businesses in Minnesota, (b) identify unique problems encountered by Latino retail entrepreneurs, and (c) develop recommendations to overcome obstacles encountered. To meet our objectives, we employed two methods: a Delphi study with Latino community leaders and a case study with Latino retail entrepreneurs. Implications for Extension educators are discussed

Mobile resistome of human gut and pathogen drives anthropogenic bloom of antibiotic resistance

BACKGROUND:The impact of human activities on the environmental resistome has been documented in many studies, but there remains the controversial question of whether the increased antibiotic resistance observed in anthropogenically impacted environments is just a result of contamination by resistant fecal microbes or is mediated by indigenous environmental organisms. Here, to determine exactly how anthropogenic influences shape the environmental resistome, we resolved the microbiome, resistome, and mobilome of the planktonic microbial communities along a single river, the Han, which spans a gradient of human activities. RESULTS:The bloom of antibiotic resistance genes (ARGs) was evident in the downstream regions and distinct successional dynamics of the river resistome occurred across the spatial continuum. We identified a number of widespread ARG sequences shared between the river, human gut, and pathogenic bacteria. These human-related ARGs were largely associated with mobile genetic elements rather than particular gut taxa and mainly responsible for anthropogenically driven bloom of the downstream river resistome. Furthermore, both sequence- and phenotype-based analyses revealed environmental relatives of clinically important proteobacteria as major carriers of these ARGs. CONCLUSIONS:Our results demonstrate a more nuanced view of the impact of anthropogenic activities on the river resistome: fecal contamination is present and allows the transmission of ARGs to the environmental resistome, but these mobile genes rather than resistant fecal bacteria proliferate in environmental relatives of their original hosts. Video abstract