404 research outputs found
Escalated regeneration in sciatic nerve crush injury by the combined therapy of human amniotic fluid mesenchymal stem cells and fermented soybean extracts, Natto
Attenuation of inflammatory cell deposits and associated cytokines prevented the apoptosis of transplanted stem cells in a sciatic nerve crush injury model. Suppression of inflammatory cytokines by fermented soybean extracts (Natto) was also beneficial to nerve regeneration. In this study, the effect of Natto on transplanted human amniotic fluid mesenchymal stem cells (AFS) was evaluated. Peripheral nerve injury was induced in SD rats by crushing a sciatic nerve using a vessel clamp. Animals were categorized into four groups: Group I: no treatment; Group II: fed with Natto (16 mg/day for 7 consecutive days); Group III: AFS embedded in fibrin glue; Group IV: Combination of group II and III therapy. Transplanted AFS and Schwann cell apoptosis, inflammatory cell deposits and associated cytokines, motor function, and nerve regeneration were evaluated 7 or 28 days after injury. The deterioration of neurological function was attenuated by AFS, Natto, or the combined therapy. The combined therapy caused the most significantly beneficial effects. Administration of Natto suppressed the inflammatory responses and correlated with decreased AFS and Schwann cell apoptosis. The decreased AFS apoptosis was in line with neurological improvement such as expression of early regeneration marker of neurofilament and late markers of S-100 and decreased vacuole formation. Administration of either AFS, or Natto, or combined therapy augmented the nerve regeneration. In conclusion, administration of Natto may rescue the AFS and Schwann cells from apoptosis by suppressing the macrophage deposits, associated inflammatory cytokines, and fibrin deposits
Mitotic Potential of the Enamel Organ of the Rhesus Monkey
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66907/2/10.1177_00220345650440062901.pd
Giant Shapiro steps for two-dimensional Josephson-junction arrays with time-dependent Ginzburg-Landau dynamics
Two-dimensional Josephson junction arrays at zero temperature are
investigated numerically within the resistively shunted junction (RSJ) model
and the time-dependent Ginzburg-Landau (TDGL) model with global conservation of
current implemented through the fluctuating twist boundary condition (FTBC).
Fractional giant Shapiro steps are found for {\em both} the RSJ and TDGL cases.
This implies that the local current conservation, on which the RSJ model is
based, can be relaxed to the TDGL dynamics with only global current
conservation, without changing the sequence of Shapiro steps. However, when the
maximum widths of the steps are compared for the two models some qualitative
differences are found at higher frequencies. The critical current is also
calculated and comparisons with earlier results are made. It is found that the
FTBC is a more adequate boundary condition than the conventional uniform
current injection method because it minimizes the influence of the boundary.Comment: 6 pages including 4 figures in two columns, final versio
Mesoscale magnetism at the grain boundaries in colossal magnetoresistive films
We report the discovery of mesoscale regions with distinctive magnetic
properties in epitaxial LaSrMnO films which exhibit
tunneling-like magnetoresistance across grain boundaries. By using
temperature-dependent magnetic force microscopy we observe that the mesoscale
regions are formed near the grain boundaries and have a different Curie
temperature (up to 20 K {\it higher}) than the grain interiors. Our images
provide direct evidence for previous speculations that the grain boundaries in
thin films are not magnetically and electronically sharp interfaces. The size
of the mesoscale regions varies with temperature and nature of the underlying
defect.Comment: 4 pages of text, 4 figure
A No-Go Theorem for the Nonabelian Topological Mass Mechanism in Four Dimensions
We prove that there is no power-counting renormalizable nonabelian
generalization of the abelian topological mass mechanism in four dimensions.
The argument is based on the technique of consistent deformations of the master
equation developed by G. Barnich and one of the authors. Recent attempts
involving extra fields are also commented upon.Comment: 12 pages, latex fil
Gamma-ray emission expected from Kepler's SNR
Nonlinear kinetic theory of cosmic ray (CR) acceleration in supernova
remnants (SNRs) is used to investigate the properties of Kepler's SNR and, in
particular, to predict the gamma-ray spectrum expected from this SNR.
Observations of the nonthermal radio and X-ray emission spectra as well as
theoretical constraints for the total supernova (SN) explosion energy E_sn are
used to constrain the astronomical and particle acceleration parameters of the
system. Under the assumption that Kepler's SN is a type Ia SN we determine for
any given explosion energy E_sn and source distance d the mass density of the
ambient interstellar medium (ISM) from a fit to the observed SNR size and
expansion speed. This makes it possible to make predictions for the expected
gamma-ray flux. Exploring the expected distance range we find that for a
typical explosion energy E_sn=10^51 erg the expected energy flux of TeV
gamma-rays varies from 2x10^{-11} to 10^{-13} erg/(cm^2 s) when the distance
changes from d=3.4 kpc to 7 kpc. In all cases the gamma-ray emission is
dominated by \pi^0-decay gamma-rays due to nuclear CRs. Therefore Kepler's SNR
represents a very promising target for instruments like H.E.S.S., CANGAROO and
GLAST. A non-detection of gamma-rays would mean that the actual source distance
is larger than 7 kpc.Comment: 6 pages, 4 figures. Accepted for publication in Astronomy and
Astrophysics, minor typos correcte
Grain boundary effects on magnetotransport in bi-epitaxial films of LaSrMnO
The low field magnetotransport of LaSrMnO (LSMO) films
grown on SrTiO substrates has been investigated. A high qualtity LSMO film
exhibits anisotropic magnetoresistance (AMR) and a peak in the
magnetoresistance close to the Curie temperature of LSMO. Bi-epitaxial films
prepared using a seed layer of MgO and a buffer layer of CeO display a
resistance dominated by grain boundaries. One film was prepared with seed and
buffer layers intact, while a second sample was prepared as a 2D square array
of grain boundaries. These films exhibit i) a low temperature tail in the low
field magnetoresistance; ii) a magnetoconductance with a constant high field
slope; and iii) a comparably large AMR effect. A model based on a two-step
tunneling process, including spin-flip tunneling, is discussed and shown to be
consistent with the experimental findings of the bi-epitaxial films.Comment: REVTeX style; 14 pages, 9 figures. Figure 1 included in jpeg format
(zdf1.jpg); the eps was huge. Accepted to Phys. Rev.
Charmed Exotics in Heavy Ion Collisions
Based on the color-spin interaction in diquarks, we argue that charmed
multiquark hadrons are likely to exist. Because of the appreciable number of
charm quarks produced in central nucleus-nucleus collisions at
ultrarelativistic energies, production of charmed multiquark hadrons is
expected to be enhanced in these collisions. Using both the quark coalescence
model and the statistical hadronization model, we estimate the yield of charmed
tetraquark meson and pentaquark baryon in heavy ion
collisions at RHIC and LHC. We further discuss the decay modes of these charmed
exotic hadrons in order to facilitate their detections in experiments
Family Unification on an Orbifold
We construct a family-unified model on a Z_2xZ_2 orbifold in five dimensions.
The model is based on a supersymmetric SU(7) gauge theory. The gauge group is
broken by orbifold boundary conditions to a product of grand unified SU(5) and
SU(2)xU(1) flavor symmetry. The structure of Yukawa matrices is generated by an
interplay between spontaneous breaking of flavor symmetry and geometric factors
arising due to field localization in the extra dimension.Comment: 13 page
The 3D Structure of N132D in the LMC: A Late-Stage Young Supernova Remnant
We have used the Wide Field Spectrograph (WiFeS) on the 2.3m telescope at
Siding Spring Observatory to map the [O III] 5007{\AA} dynamics of the young
oxygen-rich supernova remnant N132D in the Large Magellanic Cloud. From the
resultant data cube, we have been able to reconstruct the full 3D structure of
the system of [O III] filaments. The majority of the ejecta form a ring of
~12pc in diameter inclined at an angle of 25 degrees to the line of sight. We
conclude that SNR N132D is approaching the end of the reverse shock phase
before entering the fully thermalized Sedov phase of evolution. We speculate
that the ring of oxygen-rich material comes from ejecta in the equatorial plane
of a bipolar explosion, and that the overall shape of the SNR is strongly
influenced by the pre-supernova mass loss from the progenitor star. We find
tantalizing evidence of a polar jet associated with a very fast oxygen-rich
knot, and clear evidence that the central star has interacted with one or more
dense clouds in the surrounding ISM.Comment: Accepted for Publication in Astrophysics & Space Science, 18pp, 8
figure
- …