Interfacial chemical bonding-mediated ionic resistive switching.

In this paper, we present a unique resistive switching (RS) mechanism study of Pt/TiO2/Pt cell, one of the most widely studied RS system, by focusing on the role of interfacial bonding at the active TiO2-Pt interface, as opposed to a physico-chemical change within the RS film. This study was enabled by the use of a non-conventional scanning probe-based setup. The nanoscale cell is formed by bringing a Pt/TiO2-coated atomic force microscope tip into contact with a flat substrate coated with Pt. The study reveals that electrical resistance and interfacial bonding status are highly coupled together. An oxygen-mediated chemical bonding at the active interface between TiO2 and Pt is a necessary condition for a non-polar low-resistance state, and a reset switching process disconnects the chemical bonding. Bipolar switching mode did not involve the chemical bonding. The nature of chemical bonding at the TiO2-metal interface is further studied by density functional theory calculations

Recombinant mussel proximal thread matrix protein promotes osteoblast cell adhesion and proliferation

BACKGROUND: von Willebrand factor (VWF) is a key load bearing domain for mamalian cell adhesion by binding various macromolecular ligands in extracellular matrix such as, collagens, elastin, and glycosaminoglycans. Interestingly, vWF like domains are also commonly found in load bearing systems of marine organisms such as in underwater adhesive of mussel and sea star, and nacre of marine abalone, and play a critical load bearing function. Recently, Proximal Thread Matrix Protein1 (PTMP1) in mussel composed of two vWF type A like domains has characterized and it is known to bind both mussel collagens and mammalian collagens. RESULTS: Here, we cloned and mass produced a recombinant PTMP1 from E. coli system after switching all the minor codons to the major codons of E. coli. Recombinant PTMP1 has an ability to enhance mouse osteoblast cell adhesion, spreading, and cell proliferation. In addition, PTMP1 showed vWF-like properties as promoting collagen expression as well as binding to collagen type I, subsequently enhanced cell viability. Consequently, we found that recombinant PTMP1 acts as a vWF domain by mediating cell adhesion, spreading, proliferation, and formation of actin cytoskeleton. CONCLUSIONS: This study suggests that both mammalian cell adhesion and marine underwater adhesion exploits a strong vWF-collagen interaction for successful wet adhesion. In addition, vWF like domains containing proteins including PTMP1 have a great potential for tissue engineering and the development of biomedical adhesives as a component for extra-cellular matrix

Effects of electromagnetic fluctuations in plasmas on solar neutrino fluxes

We explore the effects of electromagnetic (EM) fluctuations in plasmas on solar neutrino fluxes exploiting the fluctuation-dissipation theorem. We find that the EM spectrum in the solar core is enhanced by the EM fluctuations due to the high density of the Sun, which increases the radiation energy density and pressure. By the EM fluctuations involving the modified radiation formula, the central temperature decreases when the central pressure of the Sun is fixed. With a help of the empirical relation between central temperature and neutrino fluxes deduced from the numerical solar models, we present the change in each of the solar neutrino fluxes by the EM fluctuations. We also discuss the enhanced radiation pressure and energy density by the EM fluctuations for other astronomical objects

Recombinant mussel proximal thread matrix protein promotes osteoblast cell adhesion and proliferation

Background: von Willebrand factor (VWF) is a key load bearing domain for mamalian cell adhesion by binding various macromolecular ligands in extracellular matrix such as, collagens, elastin, and glycosaminoglycans. Interestingly, vWF like domains are also commonly found in load bearing systems of marine organisms such as in underwater adhesive of mussel and sea star, and nacre of marine abalone, and play a critical load bearing function. Recently, Proximal Thread Matrix Protein1 (PTMP1) in mussel composed of two vWF type A like domains has characterized and it is known to bind both mussel collagens and mammalian collagens. Results: Here, we cloned and mass produced a recombinant PTMP1 from E. coli system after switching all the minor codons to the major codons of E. coli. Recombinant PTMP1 has an ability to enhance mouse osteoblast cell adhesion, spreading, and cell proliferation. In addition, PTMP1 showed vWF-like properties as promoting collagen expression as well as binding to collagen type I, subsequently enhanced cell viability. Consequently, we found that recombinant PTMP1 acts as a vWF domain by mediating cell adhesion, spreading, proliferation, and formation of actin cytoskeleton. Conclusions: This study suggests that both mammalian cell adhesion and marine underwater adhesion exploits a strong vWF-collagen interaction for successful wet adhesion. In addition, vWF like domains containing proteins including PTMP1 have a great potential for tissue engineering and the development of biomedical adhesives as a component for extra-cellular matrix.open1151sciescopu

Anti-Biofouling Features of Eco-Friendly Oleamide-PDMS Copolymers

The biofouling of marine organisms on a surface induces serious economic damage. One of the conventional anti-biofouling strategies is the use of toxic chemicals. In this study, a new eco-friendly oleamide-PDMS copolymer (OPC) is proposed for sustainable anti-biofouling and effective drag reduction. The anti-biofouling characteristics of the OPC are investigated using algal spores and mussels. The proposed OPC is found to inhibit the adhesion of algal spores and mussels. The slippery features of the fabricated OPC surfaces are examined by direct measurement of pressure drops in channel flows. The proposed OPC surface would be utilized in various industrial applications including marine vehicles and biomedical devices. © Copyright © 2020 American Chemical Society.1

Reinvestigating the Gamow Factor of Reactions on Light Nuclei

We present a modified Gamow factor by reinvestigating the conventional assumptions used in its derivation. The conventional Gamow factor, factorized from the total cross section, effectively describes the penetration probabilities (PPs) in low-energy nuclear reactions under the assumption of particle energies significantly lower than the Coulomb barrier. However, we find that the assumption is invalid for light nuclei, resulting in PPs that depend on the nuclear potential depth for such nuclei. By adopting a potential depth fitted to experimental fusion cross sections, we demonstrate that PPs for light nuclei (D+D, D+T, D+ ^3 He, p+D, p+ ^6 Li, and p+ ^7 Li) become higher than those predicted by the conventional form near the Coulomb barrier. This reduces the Gamow peak energy by a factor of 5.3 maximally compared to the conventional form. Furthermore, we show that the enhancement factor due to the Debye screening effects in the solar core can be reduced by approximately 5%–10% due to the modified PP. Our findings hold implications for evaluating the available energy region in low-energy reaction experiments based on the Gamow peak energy region and for understanding electron screening effects in typical astrophysical environments

Dynamical Screening Effects on Big Bang Nucleosynthesis

A moving ion in plasma creates a deformed electric potential depending on the ion velocity, which leads to the distinct screening effect compared to the standard static Salpeter formula. In this paper, adopting the test charge method, we explore the dynamical screening effects on big bang nucleosynthesis (BBN). We find that the high temperature in the early universe causes the ion velocity to be faster than the solar condition so that the electric potential is effectively polarized. However, the low density of background plasma components significantly suppresses the dynamical screening effects on thermonuclear reaction rates during the BBN epoch. We compare our results with several thermonuclear reaction rates for solar fusion considering the dynamical screening effects. Also, we discuss the additional plasma properties in other astrophysical sites for the possible expansion from the present calculation in the future

Dietary Compounds for Targeting Prostate Cancer

Prostate cancer is the third most common cancer worldwide, and the burden of the disease is increased. Although several chemotherapies have been used, concerns about the side effects have been raised, and development of alternative therapy is inevitable. The purpose of this study is to prove the efficacy of dietary substances as a source of anti-tumor drugs by identifying their carcinostatic activities in specific pathological mechanisms. According to numerous studies, dietary substances were effective through following five mechanisms; apoptosis, anti-angiogenesis, anti-metastasis, microRNA (miRNA) regulation, and anti-multi-drug-resistance (MDR). About seventy dietary substances showed the anti-prostate cancer activities. Most of the substances induced the apoptosis, especially acting on the mechanism of caspase and poly adenosine diphosphate ribose polymerase (PARP) cleavage. These findings support that dietary compounds have potential to be used as anticancer agents as both food supplements and direct clinical drugs

Interfacial chemical bonding-mediated ionic resistive switching.

In this paper, we present a unique resistive switching (RS) mechanism study of Pt/TiO2/Pt cell, one of the most widely studied RS system, by focusing on the role of interfacial bonding at the active TiO2-Pt interface, as opposed to a physico-chemical change within the RS film. This study was enabled by the use of a non-conventional scanning probe-based setup. The nanoscale cell is formed by bringing a Pt/TiO2-coated atomic force microscope tip into contact with a flat substrate coated with Pt. The study reveals that electrical resistance and interfacial bonding status are highly coupled together. An oxygen-mediated chemical bonding at the active interface between TiO2 and Pt is a necessary condition for a non-polar low-resistance state, and a reset switching process disconnects the chemical bonding. Bipolar switching mode did not involve the chemical bonding. The nature of chemical bonding at the TiO2-metal interface is further studied by density functional theory calculations