Membranöse Glomerulonephritis: Ätiopathogenese, Diagnostik und moderne Therapie

Zusammenfassung: Die membranöse Glomerulonephritis (MGN) ist die häufigste Ursache eines nephrotischen Syndroms bei Erwachsenen. Meist liegt eine idiopathische Form vor, doch sollen alle potenziellen Ursachen (in erster Linie Tumoren, Medikamente oder Infekte) aktiv gesucht bzw. ausgeschlossen werden. Die Behandlung der primären MGN bleibt kontrovers. Bei 30% der Patienten tritt eine spontane Remission auf, bei 30% kommt es zur dialysepflichtigen Niereninsuffizienz. Risikofaktoren für einen ungünstigen Verlauf sind: höheres Lebensalter, männliches Geschlecht, arterielle Hypertonie, schwere Proteinurie, eingeschränkte Nierenfunktion and tubulointerstitielle Fibrose. Auf jeden Fall sollte ein ACE-Hemmer und/oder Angiotensin-II-Antagonist und ein Statin eingesetzt werden. Bei Zunahme der Proteinurie oder Verschlechterung der Nierenfunktion nach 6 Monaten besteht die Indikation zur Immunsuppression mit Steroiden in Kombination mit Cyclophosphamid oder Cyclosporin

The Role of PTEN in Tumor Angiogenesis

During the past 20 years, the phosphatase and tensin homolog PTEN has been shown to be involved in major physiological processes, and its mutation or loss is often associated with tumor formation. In addition PTEN regulates angiogenesis not only through its antagonizing effect on the PI3 kinase pathway mainly, but also through some phosphatase-independent functions. In this paper we delineate the role of this powerful tumor suppressor in tumor angiogenesis and dissect the underlying molecular mechanisms. Furthermore, it appears that, in a number of cancers, the PTEN status determines the response to chemotherapy, highlighting the need to monitor PTEN expression and to develop PTEN-targeted therapies

Determinants Affecting Intention to Use E-Wallets in Vietnam: An Empirical Case of Momo

This research endeavors to identify and assess the determinants influencing the intention to use Momo e-wallet in Ho Chi Minh City, establishing connections between these factors. The research methodology involved the design of a questionnaire based on the UTAUT model, tailored to evaluate the determinants affecting the intention to use e-wallets in Vietnam, with a specific focus on Momo. A total of 388 respondents, all Momo users, participated in the study. The results of the regression analysis revealed that all four determinants significantly impact the intention to use the Momo e-wallet, with varying levels of significance: Effort Expectancy (β=0.45), Promotional Benefits (β=0.379), Performance Expectancy (β=0.13), and Facilitating Conditions (β=0.072). Understanding these factors that influence usage intention and gaining insights into user preferences can facilitate the development of e-wallet systems that support e-wallet providers in penetrating the market and retaining their existing user base. Keywords: intention to use, e-wallets, Momo, Vietna

Mise en oeuvre du programme national VIH/sida de 1999 à 2000: état des activités en 1999 dans les différents domaines sous les angles de la couverture et de la durabilité

Le présent rapport décrit la situation en 1999 des activités dans le domaine VIH/sida en Suisse, au moment du début de la mise en oeuvre du nouveau programme national VIH/sida de 1999 à 2003. Ses objectifs sont les suivants: - décrire les principales dimensions de la situation d'ensemble au niveau national de chacun des 18 domaines considérés: instances assumant la responsabilité générale du domaine, acteurs et activités développées, couverture assurée par ces activités, financement et durabilité des activités, appréciation de la situation par les acteurs; (...) La récolte des données utilisées a consisté en une recension des activités entreprises dans les cantons dans le domaine VIH/sida, effectuée à l'aide d'un questionnaire... [Auteurs, p. 5] [Table des matières] 1. Méthodes. 1.1. Construction du questionnaire. 2. Situation dans les domaines. 2.1. Prévention sida en milieu scolaire (tous les niveaux, yc apprentissage) et pour les jeunes hors du système de formation. 2.2. Population générale, femmes et hommes hétérosexuels. 2.3. Prévention sida spécifiques selon le genre pour les femmes ou les hommes hétérosexuel(le)s / adultes (sauf HSH). 2.4. Hommes avec rapports sexuels avec des hommes (HSH). 2.5. Migrant(e)s (Populations étrangères en Suisse). 2.6. Prévention sida pour les personnes en prison : information et conseil, VIH, distribution de matériel d'injection et de désinfection, de préservatifs, etc. 2.7. Voyageurs. 2.9. Prostitution. 2.10. Toxicomanes : matériel d'injection stérile, préservatifs. 2.11. Prévention des risques professionnels. 2.12. Test de dépistage du VIH. 2.13. Prophylaxie post exposition VIH (PEP). 3. Conclusions générales. 3.1. Types de problèmes. 3.2. Définition des rôles respectifs du niveau national et du niveau régional. 5. Questionnaire sur l'état des activités dans le domaine VIH/sida en Suisse = Fragebogen zum Stand der Aktivitäten im Bereich HIV/AIDS in der Schweiz

SOLUTIONS TO IMPROVE STUDENTS' SATISFACTION IN PHYSICAL EDUCATION COURSES

The purpose of this study was to find out the solutions to improve students' satisfaction in physical education courses at Saigon University. 1378 students participated in physical education courses (such as football, volleyball, table tennis, basketball, and badminton) in the academic year 2021-2022 has been conducted by using questionnaires to survey. Through the steps of the analysis of strengths, weaknesses, opportunities, threats in teaching process, expert consultation, combined with experimental process based on 7 factors, i.e. facilities, lecturers, training program, the implementation, support process, problem responsiveness and expected results. Results had selected and applied 08 solutions to improve the satisfaction level of students at Saigon University after participating in physical education courses. In short, the application of the solutions has contributed to improving the satisfaction level of students after participating in the physical education courses.  Article visualizations

Early renal failure after domino hepatic transplantation using the liver from a compound heterozygous patient with primary hyperoxaluria

Background. To cover the shortage of cadaveric organs, new approaches to expand the donor pool are needed. Here we report on a case of domino liver transplantation (DLT) using an organ harvested from a compound heterozygous patient with primary hyperoxaluria (PHO), who underwent combined liver and kidney transplantation. The DLT recipient developed early renal failure with oxaluria. The time to the progression to oxalosis with renal failure in such situations is unknown, but, based on animal data, we hypothesize that calcineurin inhibitors may play a detrimental role. Methods. A cadaveric liver and kidney transplantation was performed in a 52-year-old male with PHO. His liver was used for a 64-year-old patient with a non-resectable, but limited cholangiocarcinoma. Results. While the course of the PHO donor was uneventful, in the DLT recipient early post-operative, dialysis-dependent renal failure with hyperoxaluria developed. Histology of a kidney biopsy revealed massive calcium oxalate crystal deposition as the leading aetiological cause. Conclusions. DLT using PHO organs for marginal recipients represents a possible therapeutic approach regarding graft function of the liver. However, it may negatively alter the renal outcome of the recipient in an unpredictable manner, especially with concomitant use of cyclosporin. Therefore, we suggest that, although DLT should be promoted, PHO organs are better excluded from such procedure

BIOSTIMULATION METHOD IN SHORELINE CLEAN-UP-AN APPROACH OF COASTAL ENVIRONMENT MANAGEMENT IN RESPONSE TO OIL-SPILL HAZARD-CASE STUDY GANH RAI GULF-VIET NAM

Joint Research on Environmental Science and Technology for the Eart