The Role of Physical Layer Security in Satellite-Based Networks

In the coming years, 6G will revolutionize the world with a large amount of bandwidth, high data rates, and extensive coverage in remote and rural areas. These goals can only be achieved by integrating terrestrial networks with non-terrestrial networks. On the other hand, these advancements are raising more concerns than other wireless links about malicious attacks on satellite-terrestrial links due to their openness. Over the years, physical layer security (PLS) has emerged as a good candidate to deal with security threats by exploring the randomness of wireless channels. In this direction, this paper reviews how PLS methods are implemented in satellite communications. Firstly, we discuss the ongoing research on satellite-based networks by highlighting the key points in the literature. Then, we revisit the research activities on PLS in satellite-based networks by categorizing the different system architectures. Finally, we highlight research directions and opportunities to leverage the PLS in future satellite-based networks

Increase in outbreaks of gastroenteritis linked to bathing water in Finland in summer 2014

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Germline TP53 alterations in Finnish breast cancer families are rare and occur at conserved mutation-prone sites

We have screened for germline TP53 mutations in Finnish BRCA1 and BRCA2 mutation-negative families. This study represents the largest survey of the entire protein-encoding portion of TP53, and indicates that mutations are only found at conserved domains in breast cancer families also meeting the criteria for Li-Fraumeni/Li-Fraumeni-like syndrome, explaining only a very small additional fraction of the hereditary breast cancer cases. © 2001 Cancer Research Campaign http://www.bjcancer.co

Recurrent hospitalizations are associated with increased mortality across the ejection fraction range in heart failure

Aims The proportion of patients hospitalized for heart failure (HF) with preserved left ventricular ejection fraction (LVEF) is rising, but no approved treatment exists, in part owing to incomplete characterization of this particular HF phenotype. In order to better define the characteristics of HF phenotypes in Finland, a large cohort with 12 years' follow-up time was analysed.Methods and results Patients diagnosed between 2005 and 2017 at the Hospital District of Southwest Finland were stratified according to LVEF measure and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. For this retrospective registry study, previously diagnosed HF patients were defined as follows: patients with reduced ejection fraction (HFrEF; LVEF 40-50% and NT-proBNP >= 125 pg/ml; n = 1468), and preserved ejection fraction (HFpEF; LVEF > 50% and NT-proBNP >= 125 pg/ml; n = 3122) and followed up for 15 022, 4962, and 10 097 patient-years, respectively. Cardiovascular (CV) hospitalization and mortality, influence of pre-selected covariates on hospitalization and mortality, and the proportion of HFpEF and HFmrEF patients with a drop in LVEF to HFrEF phenotype were analysed. All data were extracted from the electronic patient register. HFrEF patients were rehospitalized slightly earlier than HFpEF/HFmrEF patients, but the second, third, and fourth rehospitalization rates did not differ between the subgroups. Female gender and better kidney function were associated with reduced rehospitalizations in HFmrEF and HFrEF, with a non-significant trend in HFpEF. Each additional hospitalization was associated with a two-fold increased risk of death and 2.2- to 2.3-fold increased risk of CV death. All-cause mortality was higher in patients with HFpEF. Although CV mortality was less frequent in HFpEF patients, it was associated with increased NT-proBNP concentrations at index in all patient groups. During the 10 years following the index date, 26% of HFmrEF patients and 10% of HFpEF patients progressed to an HFrEF phenotype.Conclusions These findings suggest that disease progression, in terms of increased frequency of hospitalizations, and the relationship between increased number of hospitalizations and mortality are similar by LVEF phenotypes. These data highlight the importance of effective treatments that can reduce hospitalizations and suggest a role for monitoring NT-proBNP levels in the management of HFpEF patients in particular

Tornionjoen lohi-, meritaimen- ja vaellussiikakannat – yhteinen ruotsalais-suomalainen biologinen selvitys sopivien kalastussääntöjen arvioimiseksi vuodelle 2020

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Haplotype analysis in Icelandic and Finnish BRCA2 999del5 breast cancer families

To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldThe 999del5 mutation is the single, strong BRCA2 founder mutation in Iceland and the most common BRCA1/2 founder mutation in Finland. To evaluate the origin and time since spreading of the 999del5 mutation in Iceland and in Finland, we constructed haplotypes with polymorphic markers within and flanking the BRCA2 gene in a set of 18 Icelandic and 10 Finnish 999del5 breast cancer families. All Icelandic families analysed shared a common core haplotype of about 1.7 cM. The common ancestors for the Icelandic families studied were estimated to trace back to 340-1000 years, not excluding the possibility that the mutation was brought to Iceland during the settlement of the country. Analysis of the Finnish families revealed two distinct haplotypes. A rare one, found in three families in the old settlement region in southwestern Finland, shared a four-marker (0.5 cM) core haplotype with the Icelandic 999del5 haplotype. A distinct approximately 6 cM haplotype was shared by seven 999del5 Finnish families estimated to have a common ancestry 140-300 years ago. These families cluster in two geographical regions in Finland, in the very same area as those with the rare haplotype and also in the most eastern, late settlement region of Finland. The results may indicate a common ancient origin for the 999del5 mutation in Iceland and in Finland, but distinct mutational events cannot be ruled out. The surprising finding of the same mutation in two completely different haplotypes in a sparsely populated area in Finland may suggest gene conversion

Tornionjoen lohi-, meritaimen- ja vaellussiikakannat – yhteinen ruotsalais-suomalainen biologinen selvitys sopivien kalastussääntöjen arvioimiseksi vuodelle 2019

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