Transferencia en tiempos de pandemia

El área de Transferencia, como todas las de la FCE, asumió con enorme compromiso el desafío de continuar trabajando y desarrollando cada uno de sus proyectos, tanto los vigentes como aquellos que enfrentaban su puesta en marcha.Facultad de Ciencias Económica

Transferencia en tiempos de pandemia

El área de Transferencia, como todas las de la FCE, asumió con enorme compromiso el desafío de continuar trabajando y desarrollando cada uno de sus proyectos, tanto los vigentes como aquellos que enfrentaban su puesta en marcha

Turismo médico: revisión de la literatura con un enfoque económico

El turismo médico (TM) adquiere cada vez más relevancia a nivel mundial: el tamaño del mercado se encuentra entre 74-92 mil millones de USD. Se estima que el mercado crece a una tasa de entre del 15-25% anual, orientándose los mayores flujos de pacientes hacia México y el sudeste y sur de Asia. A partir de lo hallado en la revisión sistemática de la literatura de TM sobre metodologías de medición cuantitativas y de la búsqueda de datos sobre TM, el objetivo es contribuir a la estimación del volumen, tendencia y/o impacto económico del fenómeno, en particular para los países de América Latina y Caribe (ALyC).Facultad de Ciencias Económica

Medical Tourism: Systematized literature review and evidence

Este trabajo realiza una revisión sistematizada de la literatura sobre turismo médico con el fin de conocer sus principales características y contribuir a la evidencia cuantitativa en el ámbito internacional. El concepto turismo médico carece de una definición consensuada y las cuestiones de volumen e impacto son discutidas por la literatura de forma principalmente narrativa y teórica. Se realiza un análisis de las metodologías aplicadas en la literatura y se toma el modelo de Loh (2013) para analizar las tendencias mundiales del turismo médico. Se utilizaron las series de viajes personales relacionados con la salud del Fondo Monetario Internacional para 2008-2017, incorporando efectos fijos y variables de control al modelo de regresión lineal. No se halla evidencia concluyente de una tendencia creciente del turismo médico. Los países de mayores ingresos son los que más comercian estas actividades. Casi todas las regiones superan a América Latina y Caribe en volumen de turismo médico.This research work carries out a systematized literature review on medical tourism in order to know its main characteristics and contributes to the quantitative evidence in the international arena. The term medical tourism lacks an agreed definition and volume and impact issues are discussed in the literature mainly in a narrative and theoretical way. An analysis of the methodologies applied in the literature is conducted and Loh (2013) is taken as a basis to analyze medical tourism world trends using health-related personal travel series from the International Monetary Fund for 2008-2017 and incorporating fixed effects and control variables to the linear regression model. There is no conclusive evidence of a growing trend in medical tourism imports and exports. Higher-income countries are the ones that trade these activities the most. Almost all regions exceed Latin America and the Caribbean's medical tourism volumes.Facultad de Ciencias Económica

Turismo médico: revisión de la literatura desde una perspectiva económica

Realizar una revisión sistemática de la literatura para identificar consensos en la definición del TM, su relevancia, potencial económico e impacto, y características de los artículos publicados, enfocando a países de América Latina. Identificar las principales líneas de avance futuras del TM en la región.Facultad de Ciencias Económica

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

Protein ubiquitination is a dynamic and reversibleprocess of adding single ubiquitin molecules orvarious ubiquitin chains to target proteins. Here,using multidimensional omic data of 9,125 tumorsamples across 33 cancer types from The CancerGenome Atlas, we perform comprehensive molecu-lar characterization of 929 ubiquitin-related genesand 95 deubiquitinase genes. Among them, we sys-tematically identify top somatic driver candidates,including mutatedFBXW7with cancer-type-specificpatterns and amplifiedMDM2showing a mutuallyexclusive pattern withBRAFmutations. Ubiquitinpathway genes tend to be upregulated in cancermediated by diverse mechanisms. By integratingpan-cancer multiomic data, we identify a group oftumor samples that exhibit worse prognosis. Thesesamples are consistently associated with the upre-gulation of cell-cycle and DNA repair pathways, char-acterized by mutatedTP53,MYC/TERTamplifica-tion, andAPC/PTENdeletion. Our analysishighlights the importance of the ubiquitin pathwayin cancer development and lays a foundation fordeveloping relevant therapeutic strategies