The electioneering methods of the Victorian Conservative Party and how they shaped Scotland’s political culture

Focusing on the Scottish Conservative Party’s innovative electoral registration activities in the 1830s and 1840s, as well as its use of illegitimate tactics to influence electors, Gary D. Hutchison discusses how the party shaped the underlying culture of Scottish politics

Editorial

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Origins of the Scottish Conservative Party, 1832–1868

This thesis examines the Scottish Conservative party between 1832 and 1868. It focuses on the party’s organisation, structure, leadership, and attitudes. It begins by examining the social, occupational, educational, and religious background of its MPs, candidates, and peers. This reveals that the party’s composition, while predominantly aristocratic, nevertheless boasted a range of distinctive and often competing interests. The thesis then explores the make-up, organisation and activity of the party on a local constituency level. This illustrates that the party was more inclusive and heterogeneous than might be assumed, and was very active in promoting itself through a wide variety of methods. The party thus had a notable impact on the wider social and cultural life of Scotland throughout the mid-nineteenth century. Following this, the structure and leadership of the Scottish party on a national level is examined. These could be a source of innovation and accomplishment, and their subsequent decline had a marked effect on the party’s overall performance. Above this level, the party’s role in parliament, governance, and in a British context is explored. It is demonstrated that the Scottish party maintained a modicum of distinctiveness even at Westminster. Moreover, its multifaceted role in Scottish governance gave it significant influence over Scottish society. Finally, the positions of the Scottish party on important political issues are examined, as are the underlying attitudes which determined these positions. The Scottish party contained many competing and overlapping factions, which held a hitherto unsuspected diversity of outlooks. Overall, this thesis illustrates that the Scottish Conservative party had a pronounced effect on many different facets of Scottish politics and wider society, and was itself more complex and more popular than is reflected in the existing historiography. It therefore counters the assumption that Scotland was almost hegemonically Liberal – a finding which has potential implications for scholarship spread across Scottish and British political, social, and cultural history

Proinflammatory Markers in Prediction of Posttraumatic Psychological Symptoms: A Prospective Cohort Study

Introduction. Posttraumatic psychopathology (PTP) describes the spectrum of conditions that can complicate the recovery from commonly occurring musculoskeletal trauma. There is a clear association with the activation of the hypothalamic-pituitary-adrenal axis (HPAA), and we wished to examine the predictive value of proinflammatory markers of the HPAA and of the GABA, which acts as an inhibitory regulator. Methods. Levels of proinflammatory markers and GABA were measured in 84 patients who had suffered musculoskeletal injuries requiring hospitalisation. PTP was assessed by the use of the General Health Questionnaire (GHQ) at presentation and again at two- and six-month reviews. Results. Significant psychological disturbance was noted in 39% of patients at two months and falling back to 18% by six months. There was no correlation between any of the markers tested at presentation and PTP at follow-up. Discussion. The HPAA response to trauma and the development of PTP are extremely complex. It is unlikely that a simple blood assay will provide significant predictive information, while incident specific information and patient perception are of more practical use

Engineered Nanomaterial Impact in the Liver following Exposure via an Intravenous Route–The Role of Polymorphonuclear Leukocytes and Gene Expression in the Organ

Background and methods: Following exposure via a number of routes (inhalation, ingestion or injection), someNanomaterials (NMs) translocate to secondary tissues, prominently the liver. This study investigated the effects of anarray of NMs, varying in their physicochemical characteristics, consisting of two types of Zinc Oxide (ZnO), two MultiwalledCarbon Nanotubes (MWCNT), one silver (Ag) and one titanium dioxide (TiO2) on the liver, following Intravenous(IV) exposure of C57/BL6 mice. The animals were exposed to either a single dose of NM (128 μg/ml–100 μl) or threedoses of (64 μg/ml–100 μl), every 24 hr. Animals were dissected 6, 24, 48 and 72 hr after the single IV injection, or 72hr after the triple injection regime.Results and conclusions: A Myeloperoxidase (MPO) assay was utilised to quantify neutrophil influx into thetissue. However, as MPO is also found in other granulocytes in smaller quantities, the neutrophils in the liver tissue werealso labelled, using a specific neutrophil cell surface marker (Ly-6B.2). A wide array of NMs (including ZnO, Ag, TiO2and MWCNT) induced a neutrophil influx into the liver, as early as 6 hr post IV exposure. However, the neutrophils wereonly involved in the initial phases of the immune response against the NMs, as the leukocyte numbers had returned tocontrol levels after 48 hr. Finally, analysis of mRNA expression in mice livers showed alterations in levels of C3, IL6,IL10, CXCL2 and ICAM-1

An in vitro liver model - assessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanomaterials

Background:Following exposure via inhalation, intratracheal instillation or ingestion some nanomaterials (NM) have been shown to translocate to the liver. Since oxidative stress has been implicated as a possible mechanism for NM toxicity this study aimed to investigate the effects of various materials (five titanium dioxide (TiO2), two zinc oxide (ZnO), two multi-walled carbon nanotubes (MWCNT) and one silver (Ag) NM) on oxidative responses of C3A cell line as a model for potential detrimental properties of nanomaterials on the liver.Results:We noted a dose dependant decrease in the cellular glutathione content following exposure of the C3A cells to Ag, the ZnO and the MWCNTs. Intracellular ROS levels were also measured and shown to increase significantly following exposure of the C3A to the low toxicity NMs (MWCNT and TiO2). The antioxidant Trolox in part prevented the detrimental effect of NMs on cell viability, and decreased the NM induced IL8 production after exposure to all but the Ag particulate. Following 4?hr exposure of the C3A cells to sub-lethal levels of the NMs, the largest amount of DNA damage was induced by two of the TiO2 samples (7?nm and the positively charged 10?nm particles).Conclusions:All ten NMs exhibited effects on the hepatocyte cell line that were at least in part ROS/oxidative stress mediated. These effects included mild genotoxicity and IL8 production for all NM except the Ag possibly due to its highly cytotoxic nature

Identification of the mechanisms that drive the toxicity of TiO2 particulates: the contribution of physicochemical characteristics

This review focuses on outlining the toxicity of titanium dioxide (TiO₂) particulates in vitro and in vivo, in order to understand their ability to detrimentally impact on human health. Evaluating the hazards associated with TiO₂ particles is vital as it enables risk assessments to be conducted, by combining this information with knowledge on the likely exposure levels of humans. This review has concentrated on the toxicity of TiO₂, due to the fact that the greatest number of studies by far have evaluated the toxicity of TiO₂, in comparison to other metal oxide particulates. This derives from historical reasons (whereby the size dependency of particulate toxicity was first realised for TiO₂) and due to its widespread application within consumer products (such as sunscreens). The pulmonary and dermal hazards of TiO₂ have been a particular focus of the available studies, due to the past use of TiO₂ as a (negative) control when assessing the pulmonary toxicity of particulates, and due to its incorporation within consumer products such as sunscreens. Mechanistic processes that are critical to TiO₂ particulate toxicity will also be discussed and it is apparent that, in the main, the oxidant driven inflammatory, genotoxic and cytotoxic consequences associated with TiO₂ exposure, are inherently linked, and are evident both in vivo and in vitro. The attributes of TiO₂ that have been identified as being most likely to drive the observed toxicity include particle size (and therefore surface area), crystallinity (and photocatalytic activity), surface chemistry, and particle aggregation/agglomeration tendency. The experimental set up also influences toxicological outcomes, so that the species (or model) used, route of exposure, experiment duration, particle concentration and light conditions are all able to influence the findings of investigations. In addition, the applicability of the observed findings for particular TiO₂ forms, to TiO₂ particulates in general, requires consideration. At this time it is inappropriate to consider the findings for one TiO₂ form as being representative for TiO₂ particulates as a whole, due to the vast number of available TiO₂ particulate forms and large variety of potential tissue and cell targets that may be affected by exposure. Thus emphasising that the physicochemical characteristics are fundamental to their toxicity

Key actions for a sustainable chemicals policy

Chemicals policies have spawned a wide range of regulations aimed at limiting damage to the environment and human health. Most instruments are reactive and fragmented. We propose a simple underpinning philosophy, “Do no harm”, to ensure a more sustainable, safe “chemical environment” for the future

Maternal Vitamin D Status and the Relationship with Neonatal Anthropometric and Childhood Neurodevelopmental Outcomes: Results from the Seychelles Child Development Nutrition Study

Vitamin D has an important role in early life; however, the optimal vitamin D status during pregnancy is currently unclear. There have been recent calls for pregnant women to maintain circulating 25-hydroxyvitamin D (25(OH)D) concentrations >100 nmol/L for health, yet little is known about the long-term potential benefits or safety of achieving such high maternal 25(OH)D concentrations for infant or child health outcomes. We examined maternal vitamin D status and its associations with infant anthropometric and later childhood neurocognitive outcomes in a mother-child cohort in a sun-rich country near the equator (4.6° S). This study was conducted in pregnant mothers originally recruited to the Seychelles Child Development Nutrition Study. Blood samples (n = 202) taken at delivery were analysed for serum 25-hydroxyvitamin D (25(OH)D) concentrations. Multiple linear regression models assessed associations between maternal 25(OH)D and birth weight, infant head circumference, and neurocognitive outcomes in the children at age 5 years. Mothers were, on average, 27 years of age, and the children’s average gestational age was 39 weeks. None of the women reported any intake of vitamin D supplements. Maternal 25(OH)D concentrations had a mean of 101 (range 34–218 nmol/L) and none were deficient (<30 nmol/L). Maternal 25(OH)D concentrations were not associated with child anthropometric or neurodevelopmental outcomes. These findings appear to indicate that a higher vitamin D status is not a limiting factor for neonatal growth or neurocognitive development in the first 5 years of life. Larger studies with greater variability in vitamin D status are needed to further explore optimal cut-offs or non-linear associations (including for maternal health) that might exist among populations with sub-optimal exposure