Concurrent TNFRSF1A R92Q and pyrin E230K mutations in a child with multiple sclerosis

We report a 16-year-old female patient with a severe course of multiple sclerosis and concomitant symptoms suggestive of a hereditary autoinflammatory disease. Genetic analyses revealed that she inherited a TNFRSF1A R92Q mutation from her mother and a pyrin E230K mutation from her father. To our knowledge, this is the first report of a patient with severe childhood multiple sclerosis and mutations in two genes which predispose to hereditary autoinflammatory disorders. We speculate that these mutations contribute to early multiple sclerosis manifestation and enhance the inflammatory damage inflicted by the autoimmune response

The Legal Foundation–Defining the Legislative Format

Current and pending mediation legislative programs in the United States, Canada, and other countries were examined by speakers and panelists who are living under these new systems or were authors of their design. Topics included court annexed programs, mandatory programs, voluntary programs, private institutional programs, the Uniform Mediation Act, state and federal initiatives, and the impact each has, or will have, on the mediation practice

Fiducial cross sections for the lepton-pair-plus-photon decay mode in Higgs production up to NNLO QCD

The rare three-body decay of a Higgs boson to a lepton-antilepton pair and a photon is starting to become experimentally accessible at the LHC. We investigate how higher-order QCD corrections to the dominant gluon-fusion production process impact on the fiducial cross sections in this specific Higgs decay mode for electrons and muons. Corrections up to NNLO QCD are found to be sizeable. They are generally uniform in kinematical variables related to the Higgs boson, but display several distinctive features in the kinematics of its individual decay products

Phase correlation of laser waves with arbitrary frequency spacing

The theoretically predicted correlation of laser phase fluctuations in Lambda-type interaction schemes is experimentally demonstrated. We show, that the mechanism of correlation in a Lambda scheme is restricted to high frequency noise components, whereas in a double-$\Lambda$ scheme, due to the laser phase locking in closed-loop interaction, it extends to all noise frequencies. In this case the correlation is weakly sensitive to coherence losses. Thus the double-Lambda scheme can be used to correlate e.m. fields with carrier frequency differences beyond the GHz regime.Comment: 4 pages, 4 figure

Automation of antenna subtraction in colour space: gluonic processes

We present the colourful antenna subtraction method, a reformulation of the antenna subtraction scheme for next-to-next-to-leading order (NNLO) calculations in QCD. The aim of this new approach is to achieve a general and process-independent construction of the subtraction infrastructure at NNLO. We rely on the predictability of the infrared singularity structure of one- and two-loop amplitudes in colour space to generate virtual subtraction terms and, subsequently, we define an automatable procedure to systematically infer the expression of the real subtraction terms, guided by the correspondence between unintegrated and integrated antenna functions. To demonstrate the applicability of the described approach, we compute the full colour NNLO correction to gluonic three-jet production pp(gg) → ggg, in the gluons-only assumption

Automation of antenna subtraction in colour space: gluonic processes

We present the colourful antenna subtraction method, a reformulation of the antenna subtraction scheme for next-to-next-to-leading order (NNLO) calculations in QCD. The aim of this new approach is to achieve a general and process-independent construction of the subtraction infrastructure at NNLO. We rely on the predictability of the infrared singularity structure of one- and two-loop amplitudes in colour space to generate virtual subtraction terms and, subsequently, we define an automatable procedure to systematically infer the expression of the real subtraction terms, guided by the correspondence between unintegrated and integrated antenna functions. To demonstrate the applicability of the described approach, we compute the full colour NNLO correction to gluonic three-jet production pp(gg)→ggg, in the gluons-only assumption