No Evidence for Gamma-Ray Burst/Abell Cluster or Gamma- Ray Burst/Radio-Quiet Quasar Correlations

We examine the recent claims that cosmic gamma-ray bursts are associated with either radio-quiet quasars or Abell clusters. These associations were based on positional coincidences between cataloged quasars or Abell clusters, and selected events from the BATSE 3B catalog of gamma-ray bursts. We use a larger sample of gamma-ray bursts with more accurate positions, obtained by the 3rd Interplanetary Network, to re-evaluate these possible associations. We find no evidence for either.Comment: Accepted for publication in the Astrophysical Journa

The Interplanetary Network Supplement to the BeppoSAX Gamma-Ray Burst Catalogs

Between 1996 July and 2002 April, one or more spacecraft of the interplanetary network detected 787 cosmic gamma-ray bursts that were also detected by the Gamma-Ray Burst Monitor and/or Wide-Field X-Ray Camera experiments aboard the BeppoSAX spacecraft. During this period, the network consisted of up to six spacecraft, and using triangulation, the localizations of 475 bursts were obtained. We present the localization data for these events.Comment: 89 pages, 3 figures. Submitted to the Astrophysical Journal Supplement Serie

Are Abell Clusters Correlated with Gamma-Ray Bursts?

A recent study has presented marginal statistical evidence that gamma-ray burst sources are correlated with Abell clusters, based on analyses of bursts in the BATSE 3B catalog. Using precise localization information from the 3rd Interplanetary Network, we have reanalyzed this possible correlation. We find that most of the Abell clusters which are in the relatively large 3B error circles are not in the much smaller IPN/BATSE error regions. We believe that this argues strongly against an Abell cluster-gamma-ray burst correlation.Comment: accepted for publication in Astrophysical Journal Letter

Where is SGR1806-20?

We apply a statistical method to derive very precise locations for soft gamma repeaters using data from the interplanetary network. We demonstrate the validity of the method by deriving a 600 arcsec^2 error ellipse for SGR1900+14 whose center agrees well with the VLA source position. We then apply it to SGR1806-20, for which we obtain a 230 arcsec^2 error ellipse, the smallest burst error box to date. We find that the most likely position of the source has a small but significant displacement from that of the non-thermal core of the radio supernova remnant G10.0-0.3, which was previously thought to be the position of the repeater. We propose a different model to explain the changing supernova remnant morphology and the positions of the luminous blue variable and the bursting source.Comment: 12 pages and 2 color figures, accepted for publication in Astrophysical Journal Letter

Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors

In humans, the aldehyde dehydrogenase superfamily consists of 19 isoenzymes which mostly catalyze the NAD(P)(+)-dependent oxidation of aldehydes. Many of these isoenzymes have overlapping substrate specificities and therefore their potential physiological functions may overlap. Thus the development of new isoenzyme-selective probes would be able to better delineate the function of a single isoenzyme and its individual contribution to the metabolism of a particular substrate. This specific study was designed to find a novel modulator of ALDH2, a mitochondrial ALDH isoenzyme most well-known for its role in acetaldehyde oxidation. 53 compounds were initially identified to modulate the activity of ALDH2 by a high-throughput esterase screen from a library of 63,000 compounds. Of these initial 53 compounds, 12 were found to also modulate the oxidation of propionaldehyde by ALDH2. Single concentration measurements at 10μM compound were performed using ALDH1A1, ALDH1A2, ALDH1A3, ALDH2, ALDH1B1, ALDH3A1, ALDH4A1, and/or ALDH5A1 to determine the selectivity of these 12 compounds toward ALDH2. Four of the twelve compounds shared an aromatic lactone structure and were found to be potent inhibitors of the ALDH1/2 isoenzymes, but have no inhibitory effect on ALDH3A1, ALDH4A1 or ALDH5A1. Two of the aromatic lactones show selectivity within the ALDH1/2 class, and one appears to be selective for ALDH2 compared to all other isoenzymes tested

INTEGRAL discovery of persistent hard X-ray emission from the Soft Gamma Ray Repeater SGR 1806-20

We report the discovery of persistent hard X-ray emission extending up to 150 keV from the soft gamma-ray repeater SGR 1806-20 using data obtained with the INTEGRAL satellite in 2003-2004. Previous observations of hard X-rays from objects of this class were limited to short duration bursts and rare transient episodes of strongly enhanced luminosity (``flares''). The emission observed with the IBIS instrument above 20 keV has a power law spectrum with photon index in the range 1.5-1.9 and a flux of 3 milliCrabs, corresponding to a 20-100 keV luminosity of ~10^36 erg s^-1 (for a distance of 15 kpc). The spectral hardness and the luminosity correlate with the level of source activity as measured from the number of emitted bursts.Comment: 5 pages, 3 figures, Revised version accepted for publication in Astronomy and Astrophysics Letter

Previously Claimed(/Unclaimed) X-ray Emission Lines in High Resolution Afterglow Spectra

We review the significance determination for emission lines in the Chandra HETGS spectrum for GRB020813, and we report on a search for additional lines in high resolution Chandra spectra. No previously unclaimed features are found. We also discuss the significance of lines sets reportedly discovered using XMM data for GRB011211 and GRB030227. We find that these features are likely of modest, though not negligible, significance.Comment: 4 pages, 1 figures, to appear in Santa Fe GRB Conference Proceedings, 200

Chandra Observations of the Optically Dark GRB030528

The X-ray-rich GRB030528 was detected by the HETE satellite and its localization was rapidly disseminated. However, early optical observations failed to detect a counterpart source. In a 2-epoch ToO observation with Chandra, we discovered a fading X-ray source likely counterpart to GRB030528. The source brightness was typical of X-ray afterglows observed at similar epochs. Other observers detected an IR source at a location consistent with the X-ray source. The X-ray spectrum is not consistent with a large absorbing column.Comment: 4 pages, 1 figures, to appear in Santa Fe GRB Conference Proceedings, 200