11 research outputs found
<b>The Anti-inflammatory Potential of a Strain of Probiotic</b> Bifidobacterium pseudocatenulatum <b>G7:</b> <i><b>In Vitro</b></i> <b>and</b> <i><b>In Vivo</b></i> <b>Evidence</b>
The genus Bifidobacterium has been
widely used in functional foods for health promotion due to its beneficial
effects on human health, especially in the gastrointestinal tract
(GIT). In this study, we characterize the anti-inflammatory potential
of the probiotic strain Bifidobacterium pseudocatenulatum G7, isolated from a healthy male adult. G7 secretion inhibited inflammatory
response in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.
Moreover, oral administration of bacteria G7 alleviated the severity
of colonic inflammation in dextran sulfate sodium (DSS)-treated colitis
mice, which was evidenced by a decreased disease activity index (DAI)
and enhanced structural integrity of the colon. The 16S rRNA gene
sequencing result illustrated that the G7 alleviated DSS-induced gut
microbiota dysbiosis, accompanied by the modulated bile acids and
short-chain fatty acid (SCFA) levels. Overall, our results demonstrated
the potential anti-inflammatory effects of Bifidobacterium
pseudocatenulatum G7 on both in vitro and in vivo models, which provided a solid foundation
for further development of a novel anti-inflammatory probiotic