Effect of automated red cell exchanges on oxygen saturation on-air, blood parameters and length of hospitalization in sickle cell disease patients with acute chest syndrome

BACKGROUND: Red cell exchanges (RCEs) lead to improvement in tissue oxygenation and reduction in inflammatory markers in sickle cell disease (SCD) patients who present with acute chest syndrome (ACS). The aim of this study is to evaluate the effects of automated-RCE (auto-RCE) on oxygen saturation (SpO2) on-air, blood counts, the time to correct the parameters and length of hospitalization after the exchange in SCD patients presenting with ACS. SUBJECTS AND METHODS: This was 2 years study involving five SCD patients; the time for SpO2 on air to increase to ≥95% and chest symptoms to resolve, postprocedure, as well as the length of in-patient hospitalization was recorded. All data were entered into Statistical Package for Social Sciences Version 20.0 (SPSS Inc., Chicago, IL, USA) computer software for analyses. RESULTS: The study involved 4 (80%) hemoglobin (Hb) SS and 1 (20%) HbSC patients. The median time of SpO2 recovery was 24 h, ranging from 6 to 96 h. About 60% (3/5) of patients achieved optimal SpO2 within 24 h post-RCE, while discharge from intensive care unit was 24 h after auto-RCE in one patient. The Hb concentration was significantly higher, while the total white cell and absolute neutrophil counts were significantly lower at the time of resolution of symptoms, compared to before auto-RCE (P < 0.05). The average post auto-red cell transfusion symptoms duration was 105.6 (24-240) h while mean inpatient stay was 244.8 (144-456) h. CONCLUSION: Auto-RCE could reverse hypoxia in ACS within 24 h

Smoothing effect and delocalization of interacting Bose-Einstein condensates in random potentials

We theoretically investigate the physics of interacting Bose-Einstein condensates at equilibrium in a weak (possibly random) potential. We develop a perturbation approach to derive the condensate wavefunction for an amplitude of the potential smaller than the chemical potential of the condensate and for an arbitrary spatial variation scale of the potential. Applying this theory to disordered potentials, we find in particular that, if the healing length is smaller than the correlation length of the disorder, the condensate assumes a delocalized Thomas-Fermi profile. In the opposite situation where the correlation length is smaller than the healing length, we show that the random potential can be significantly smoothed and, in the meanfield regime, the condensate wavefunction can remain delocalized, even for very small correlation lengths of the disorder.Comment: The word "screening" has been changed to "smoothing" to avoid confusions with other effects discussed in the literature. This does not affect the content of paper, nor the results, nor the physical discussio

Orbitally excited and hybrid mesons from the lattice

We discuss in general the construction of gauge-invariant non-local meson operators on the lattice. We use such operators to study the $P$- and $D$-wave mesons as well as hybrid mesons in quenched QCD, with quark masses near the strange quark mass. The resulting spectra are compared with experiment for the orbital excitations. For the states produced by gluonic excitations (hybrid mesons) we find evidence of mixing for non-exotic quantum numbers. We give predictions for masses of the spin-exotic hybrid mesons with $J^{PC}=1^{-+},\ 0^{+-}$, and$2^{+-}$.Comment: 31 pages, LATEX, 8 postscript figures. Reference adde

Atom cooling and trapping by disorder

We demonstrate the possibility of three-dimensional cooling of neutral atoms by illuminating them with two counterpropagating laser beams of mutually orthogonal linear polarization, where one of the lasers is a speckle field, i.e. a highly disordered but stationary coherent light field. This configuration gives rise to atom cooling in the transverse plane via a Sisyphus cooling mechanism similar to the one known in standard two-dimensional optical lattices formed by several plane laser waves. However, striking differences occur in the spatial diffusion coefficients as well as in local properties of the trapped atoms.Comment: 11 figures (postscript

Potential Aboriginal-Occupation-Induced Dune Activity, Elbow Sand Hills, Northern Great Plains, Canada

Geomorphological and archeological evidence indicates potential linkages between Plains aboriginal occupation and dune activity in the Elbow Sand Hills of southern Saskatchewan, Canada. Vegetation encroachment has rapidly outpaced migration of an active dune complex over the last 65 years. Optical ages of stabilized dune remnants indicate that dune activity predates Euro-Canadian settlement (ca. AD 1900). Early Euro-Canadian explorers observed local occupation and exploitation of the sand hills by aboriginal groups for herding and impounding bison. Mapping of archeological sites in relation to physiography reveals that sand dunes, in close proximity to permanent water resources, were preferred areas of occupation. Collectively, these results support the hypothesis that aboriginal occupation disturbance may have perpetuated dune activity in the Elbow Sand Hills until the late 19th century, and that Euro-Canadian settlement and land use emphasizing conservation may have encouraged recent stabilization. We propose that similar aboriginal occupation disturbances may have been responsible for perpetuating dune activity in other dune fields in the Great Plains. To this end, climatic variability should not be considered exclusive of other drivers of dune activity in semivegetated inland dune fields of the Great Plains

Temperature scaling in a dense vibro-fluidised granular material

The leading order "temperature" of a dense two dimensional granular material fluidised by external vibrations is determined. An asymptotic solution is obtained where the particles are considered to be elastic in the leading approximation. The velocity distribution is a Maxwell-Boltzmann distribution in the leading approximation. The density profile is determined by solving the momentum balance equation in the vertical direction, where the relation between the pressure and density is provided by the virial equation of state. The predictions of the present analysis show good agreement with simulation results at higher densities where theories for a dilute vibrated granular material, with the pressure-density relation provided by the ideal gas law, are in error. The theory also predicts the scaling relations of the total dissipation in the bed reported by McNamara and Luding (PRE v 58, p 813).Comment: ReVTeX (psfrag), 5 pages, 5 figures, Submitted to PR

Awareness in severe Alzheimer’s disease: a systematic review

OBJECTIVE: There is limited understanding about how people in the severe stages of Alzheimer’s disease (AD) experience and demonstrate awareness. We synthesised all available evidence with the aim of understanding how awareness is preserved or impaired in severe AD and what evidence there is for different levels of awareness according to the levels of awareness framework. METHOD: A systematic search of the following databases: Embase, PsycINFO, MEDLINE and Web of Science was carried out. A narrative synthesis and analysis was conducted of all included studies. All studies were assessed for quality using the AXIS and CASP tools. RESULTS: Our findings suggest that lower level sensory awareness is relatively maintained in severe AD. Findings for higher level awareness are variable and this may be related to the diversity of methods that have been used to explore awareness in these circumstances. CONCLUSION: Awareness is complex, heterogeneous and varies significantly between individuals. Environmental and contextual factors have a significant impact on whether awareness is observed in people with severe AD. Adaptation of the environment has the potential to facilitate the expression of awareness while education of caregivers may increase understanding of people with severe AD and potentially improve the quality of care that is received

A Study of Degenerate Four-quark states in SU(2) Lattice Monte Carlo

The energies of four-quark states are calculated for geometries in which the quarks are situated on the corners of a series of tetrahedra and also for geometries that correspond to gradually distorting these tetrahedra into a plane. The interest in tetrahedra arises because they are composed of {\bf three } degenerate partitions of the four quarks into two two-quark colour singlets. This is an extension of earlier work showing that geometries with {\bf two} degenerate partitions (e.g.\ squares) experience a large binding energy. It is now found that even larger binding energies do not result, but that for the tetrahedra the ground and first excited states become degenerate in energy. The calculation is carried out using SU(2) for static quarks in the quenched approximation with $\beta=2.4$ on a $16^3\times 32$ lattice. The results are analysed using the correlation matrix between different euclidean times and the implications of these results are discussed for a model based on two-quark potentials.Comment: Original Raw PS file replace by a tarred, compressed and uuencoded PS fil