Fish Landings at the World’s Commercial Fishing Ports

In 2009, the United Nations Food and Agriculture Organization (FAO) adopted the Agreement on Port State Measures to Prevent, Deter and Eliminate Illegal, Unreported and Unregulated (IUU) fishing (PSMA). Countries that ratify the treaty commit to exert greater control at ports over foreign-flagged vessels to detect IUU catch before it is offloaded from vessels, and prevent the ill-gotten catch from entering the world’s markets. The PSMA, when effectively implemented globally, will be a major deterrent to IUU fishing. A major challenge to selecting ports for enhanced controls has been the lack of data on which ports are the world’s largest or busiest. There is no global ranking of major fishing ports of any kind, so the goal of this work was to identify, rank and characterize the world’s ports for the purpose of assessing what the impact the PSMA could have at the country level. This list of the top 100 ports by landed tonnage is one of the first of its kind to be published as a single consolidated dataset, and it is intended as a starting point in the further assessment of activity in the world’s fishing ports

Any Port in a Storm: Vessel Activity and the Risk of IUU-Caught Fish Passing through the World’s Most Important Fishing Ports

This study assesses the risk of fish from illegal, unregulated and unreported (IUU) sources passing through the world’s most important fishing ports and explores the drivers of this risk. Like previous studies it has attempted to rank ports and States based on landings and vessel visits reported by governments by using Automatic Identification System (AIS) positional data transmitted by fishing and fish carrier vessels to identify the locations of ports and rank them based on the frequency of visits by foreign-flagged and domestic-flagged vessels. It advances our thinking in that (i) the analysis includes an estimation of the hold capacity of fishing vessels and is therefore able to rank ports based on the total hold capacity of vessels visiting them and (ii) the profile and the frequency of vessel visits inform an assessment of the relative risks between different ports, and the implications for the implementation of the Port State Measures Agreement (PSMA). The study also assesses the accuracy and utility of AIS-derived data for determining IUU risk globally for all ports, notably by cross-referencing its findings with those of other studies. The study develops a broad suite of indicators that quantify and aggregate the AIS-derived port visit information in conjunction with published and publicly available policy and regulatory information drawn from other sources, such as the compliance record with binding port State measures of regional fisheries management organizations, to raise a global port State IUU Risk Index. The comparison of achieved risk scores with national income, levels of corruption, and geography provides insights into factors driving (aggravating) or modulating (mitigating) risks of IUU-caught seafood passing through a Nation’s fishing ports, and supports a view that States with weaker governance also face higher odds of visits by vessels likely to have engaged in IUU fishing (i.e. higher external risks). Based on an in-depth assessment of 14 individual ports globally, appended as a supplement to this paper, the study finds that overall, and with the possible exception of mandatory advance request procedures for entering ports, the implementation of key provisions of the 2009 PSMA remains severely lacking. The two main areas for improvement are the posting of publicly available PSM-related information on national and/or FAO portals, and the formal designation of ports

Generation of Human Antigen-Specific Monoclonal IgM Antibodies Using Vaccinated “Human Immune System” Mice

Passive transfer of antibodies not only provides immediate short-term protection against disease, but also can be exploited as a therapeutic tool. However, the 'humanization' of murine monoclonal antibodies (mAbs) is a time-consuming and expensive process that has the inherent drawback of potentially altering antigenic specificity and/or affinity. The immortalization of human B cells represents an alternative for obtaining human mAbs, but relies on the availability of biological samples from vaccinated individuals or convalescent patients. In this work we describe a novel approach to generate fully human mAbs by combining a humanized mouse model with a new B cell immortalization technique. After transplantation with CD34+CD38⁻ human hematopoietic progenitor cells, BALB/c Rag2⁻/⁻IL-2Rγc⁻/⁻ mice acquire a human immune system and harbor B cells with a diverse IgM repertoire. "Human Immune System" mice were then immunized with two commercial vaccine antigens, tetanus toxoid and hepatitis B surface antigen. Sorted human CD19+CD27+ B cells were retrovirally transduced with the human B cell lymphoma (BCL)-6 and BCL-XL genes, and subsequently cultured in the presence of CD40-ligand and IL-21. This procedure allows generating stable B cell receptor-positive B cells that secrete immunoglobulins. We recovered stable B cell clones that produced IgM specific for tetanus toxoid and the hepatitis B surface antigen, respectively. This work provides the proof-of-concept for the usefulness of this novel method based on the immunization of humanized mice for the rapid generation of human mAbs against a wide range of antigen

NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development

The activation of natural killer (NK) cells depends on a change in the balance of signals from inhibitory and activating receptors. The activation threshold values of NK cells are thought to be set by engagement of inhibitory receptors during development. Here, we found that the activating receptor NKG2D specifically set the activation threshold for the activating receptor NCR1 through a process that required the adaptor DAP12. As a result, NKGD2-deficient (Klrk1-/-) mice controlled tumors and cytomegalovirus infection better than wild-type controls through the NCR1-induced production of the cytokine IFN-γ. Expression of NKG2D before the immature NK cell stage increased expression of the adaptor CD3ζ. Reduced expression of CD3ζ in Klrk1-/- mice was associated with enhanced signal transduction through NCR1, and CD3ζ deficiency resulted in hyper-responsiveness to stimulation via NCR1. Thus, an activating receptor developmentally set the activity of another activating receptor on NK cells and determined NK cell reactivity to cellular threats

New Labour: New Christian Democracy?

The rise of New Labour and its associated politics of the 'third way' is undoubtedly one of the most talked about political phenomena of the past decade. Few, though, can agree on just what it is they are talking about. Some argue it represents a truly novel and distinctive centre-left approach - a form of social democracy designed to cope with the 'realities' of modern politics. Others see it as a largely rhetorical construct: a set of soundbites designed to disguise either a return to traditional social democratic eclecticism or, more commonly, a historic capitulation to neo-liberalism and globalisation. There seems little hope for a conclusive end to this debate in the near future. Certainly, anyone hoping that Labour's second term will serve to settle the question once and for all would be well advised not to hold their breath

Any Port in a Storm: Vessel Activity and the Risk of IUU-Caught Fish Passing through the Worlds Most Important Fishing Ports

This study assesses the risk of fish from illegal, unregulated and unreported (IUU) sources passing through the world's most important fishing ports and explores the drivers of this risk.Like previous studies it has attempted to rank ports and States based on landings and vessel visits reported by governments by using Automatic Identification System (AIS) positional data transmitted by fishing and fish carrier vessels to identify the locations of ports and rank them based on the frequency of visits by foreignflagged and domestic-flagged vessels. It advances our thinking in that (i) the analysis includes an estimation of the hold capacity of fishing vessels and is therefore able to rank ports based on the total hold capacity of vessels visiting them and (ii) the profile and the frequency of vessel visits inform an assessment of the relative risks between different ports, and the implications for the implementation of the Port State Measures Agreement (PSMA). The study also assesses the accuracy and utility of AIS-derived data for determining IUU risk globally for all ports, notably by cross-referencing its findings with those of other studies.The study develops a broad suite of indicators that quantify and aggregate the AIS-derived port visit information in conjunction with published and publicly available policy and regulatory information drawn from other sources, such as the compliance record with binding port State measures of regional fisheries management organizations, to raise a global port State IUU Risk Index. The comparison of achieved risk scores with national income, levels of corruption, and geography provides insights into factors driving (aggravating) or modulating (mitigating) risks of IUU-caught seafood passing through a Nation's fishing ports, and supports a view that States with weaker governance also face higher odds of visits by vessels likely to have engaged in IUU fishing (i.e. higher external risks).Based on an in-depth assessment of 14 individual ports globally, appended as a supplement to this paper, the study finds that overall, and with the possible exception of mandatory advance request procedures for entering ports, the implementation of key provisions of the 2009 PSMA remains severely lacking. The two main areas for improvement are the posting of publicly available PSM-related information on national and/or FAO portals, and the formal designation of ports

A third assessment of global marine fisheries discards

201