The Ursinus Weekly, April 30, 1962

Feldstein, Shinnick and Kelly elected new class presidents • Young Democrats foresee active year under Ryan • Coeds elect reps to WSGA council • ZX & KDK winners in Pi Nu songfest • 2-part art seminar of Y successfully completed • UC mile relayers place 3rd Friday in Penn relays • Haeussner elected president of MSGA • Women voters tap new dorm officers • Y officers reveal new appointments to \u2762-63 cabinet • Myers voted veep of statewide PSEA • IFS weekend features Saylor, Hawkins rock & roll group • Debaters place in New York tourney • Spring blooms to enliven campus • Meistersingers in fine voice finish season on campus • Editorial: Right to review • Letters to the editor • Germany revisited, then to Amsterdam • Carp\u27s Washington of capitol\u27s past • Greek gleanings • Netwomen defeat Penn Varsity, JV\u27s • Lacrossers smash Penn, Swarthmore, deadlock Shipley • Cindercrew downs F&M, sets records in Swarthmore tilt • Siebmen cripple W. Maryland, lose in Hopkins upset • Tennismen suffer • Openings in Africa teaching program • Ursinus coed to enter county beauty pageanthttps://digitalcommons.ursinus.edu/weekly/1318/thumbnail.jp

Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice

Peer reviewedPublisher PD

The Ursinus Weekly, October 22, 1962

Queen & football victory highlight Saturday\u27s Homecoming festivities • Students enjoy Winterthur visit • Pre-medicals hear student talks • Gould, Moser, Harris and Miller elected as freshman officers • Recent Spike convocation provocative, analytic • Tim Cope elected as MSGA soph rep. • Sororities take in 54 women • Weekly meeting for new members • Dawson and King chosen for cheerleading squad • PSEA meeting opens season • Innkeepers tour from G-B to UC • Young GOPers outline voting procedure • Ruby sales begin • Cole family concert slated for Norristown • Millers join koffee klatch opener • Editorial: A broken back • UC coed writes of Summer experiences at reform school • A report on the customs program • The Weekly interviews 3 of our 9 foreign students • Dr. Eugene Miller reports on India in recent Forum • UC downs Swarthmore 14-8 • Players of the week: Sermarini & Ritz real hustlers • Next week\u27s opponent: Wagner • Soccermen defeat East Baptist, Delaware to remain undefeated • Hockeyettes down WC & Swarthmore • Berlinger asset on soccer field • Greek gleanings • Dean\u27s listhttps://digitalcommons.ursinus.edu/weekly/1278/thumbnail.jp

Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension

The nonreceptor tyrosine kinase encoded by the c-Abl gene has the unique feature of an F-actin binding domain (FABD). Purified c-Abl tyrosine kinase is inhibited by F-actin, and this inhibition can be relieved through mutation of its FABD. The c-Abl kinase is activated by physiological signals that also regulate the actin cytoskeleton. We show here that c-Abl stimulated the formation of actin microspikes in fibroblasts spreading on fibronectin. This function of c-Abl is dependent on kinase activity and is not shared by c-Src tyrosine kinase. The Abl-dependent F-actin microspikes occurred under conditions where the Rho-family GTPases were inhibited. The FABD-mutated c-Abl, which is active in detached fibroblasts, stimulated F-actin microspikes independent of cell attachment. Moreover, FABD-mutated c-Abl stimulated the formation of F-actin branches in neurites of rat embryonic cortical neurons. The reciprocal regulation between F-actin and the c-Abl tyrosine kinase may provide a self-limiting mechanism in the control of actin cytoskeleton dynamics

The Ursinus Weekly, February 11, 1963

President Emeritus McClure dies following recent illness: Dr. Yost pays tribute to his late colleague • Dr. Donald Baker discusses US at Koffee Klatch • Coed foursome discusses Summer with Indians • President Helfferich quizzed in Controversy at midnight chat: Topics discussed include fraternities, government aid, college isolation, library • Annual Lorelei dance scheduled for Friday evening at Sunnybrook • Legal counselor slated to address PSEA • Tennis coach displays art exhibit in Library • Living under communism topic of Wednesday\u27s Forum speaker • Bible Study film examines nature • Powers & Fuges leave UC to enlist in Peace Corps • Kachel, Berlinger elected 1964 Ruby business managers • Chi Alpha hears talk on research • Spring rushing periods begin for fraternities and sororities • Editorial: End of an era; As youth should be spent • Letters to the editor • Silver scholarships offered to coeds • Greek gleanings • Spring Mountain ski slope offers fun for both beginners and experts • Netmen downed by Haverford 80-66, eke out 65-63 win over Hopkins • Tenacious play marks Hofmann • Kratz versatile, solid, dependable • Matmen stunned by E\u27towners in 17-11 upset • Jayvee netwomen claim 46-38 win over Phila. Bible • Intramural storyhttps://digitalcommons.ursinus.edu/weekly/1286/thumbnail.jp

Timing of Invasive Mechanical Ventilation and Death in Critically Ill Adults With Covid-19: A Multicenter Cohort Study

PURPOSE: To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with mortality. MATERIALS AND METHODS: The data for this study were derived from a multicenter cohort study of critically ill adults with COVID-19 admitted to ICUs at 68 hospitals across the US from March 1 to July 1, 2020. We examined the association between early (ICU days 1-2) versus late (ICU days 3-7) initiation of IMV and time-to-death. Patients were followed until the first of hospital discharge, death, or 90 days. We adjusted for confounding using a multivariable Cox model. RESULTS: Among the 1879 patients included in this analysis (1199 male [63.8%]; median age, 63 [IQR, 53-72] years), 1526 (81.2%) initiated IMV early and 353 (18.8%) initiated IMV late. A total of 644 of the 1526 patients (42.2%) in the early IMV group died, and 180 of the 353 (51.0%) in the late IMV group died (adjusted HR 0.77 [95% CI, 0.65-0.93]). CONCLUSIONS: In critically ill adults with respiratory failure from COVID-19, early compared to late initiation of IMV is associated with reduced mortality

1965 Ruby Yearbook

A digitized copy of the 1965 Ruby, the Ursinus College yearbook.https://digitalcommons.ursinus.edu/ruby/1068/thumbnail.jp

Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis

Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites <i>Trypanosoma brucei</i> (<i>T.b.</i>) <i>gambiense</i> or <i>T.b.rhodesiense</i> and is invariably fatal if untreated. There are 60 million people at risk from the disease throughout sub-Saharan Africa. The infection progresses from the haemolymphatic stage where parasites invade the blood, lymphatics and peripheral organs, to the late encephalitic stage where they enter the central nervous system (CNS) to cause serious neurological disease. The trivalent arsenical drug melarsoprol (Arsobal) is the only currently available treatment for CNS-stage <i>T.b.rhodesiense</i> infection. However, it must be administered intravenously due to the presence of propylene glycol solvent and is associated with numerous adverse reactions. A severe post-treatment reactive encephalopathy occurs in about 10% of treated patients, half of whom die. Thus melarsoprol kills 5% of all patients receiving it. Cyclodextrins have been used to improve the solubility and reduce the toxicity of a wide variety of drugs. We therefore investigated two melarsoprol cyclodextrin inclusion complexes; melarsoprol hydroxypropyl-͎-cyclodextrin and melarsoprol randomly-methylated-β-cyclodextrin. We found that these compounds retain trypanocidal properties <i>in vitro</i> and cure CNS-stage murine infections when delivered orally, once per day for 7-days, at a dosage of 0.05 mmol/kg. No overt signs of toxicity were detected. Parasite load within the brain was rapidly reduced following treatment onset and magnetic resonance imaging showed restoration of normal blood-brain barrier integrity on completion of chemotherapy. These findings strongly suggest that complexed melarsoprol could be employed as an oral treatment for CNS-stage HAT, delivering considerable improvements over current parenteral chemotherapy

All clinically-relevant blood components transmit prion disease following a single blood transfusion: a sheep model of vCJD

Variant CJD (vCJD) is an incurable, infectious human disease, likely arising from the consumption of BSE-contaminated meat products. Whilst the epidemic appears to be waning, there is much concern that vCJD infection may be perpetuated in humans by the transfusion of contaminated blood products. Since 2004, several cases of transfusion-associated vCJD transmission have been reported and linked to blood collected from pre-clinically affected donors. Using an animal model in which the disease manifested resembles that of humans affected with vCJD, we examined which blood components used in human medicine are likely to pose the greatest risk of transmitting vCJD via transfusion. We collected two full units of blood from BSE-infected donor animals during the pre-clinical phase of infection. Using methods employed by transfusion services we prepared red cell concentrates, plasma and platelets units (including leucoreduced equivalents). Following transfusion, we showed that all components contain sufficient levels of infectivity to cause disease following only a single transfusion and also that leucoreduction did not prevent disease transmission. These data suggest that all blood components are vectors for prion disease transmission, and highlight the importance of multiple control measures to minimise the risk of human to human transmission of vCJD by blood transfusion