Speed and Surface Speed and Magnitude of Knee Adduction

Frontal plane knee biomechanics, in particular speed and magnitude of knee adduction motion, are implicated in knee osteoarthritis development. Although individuals are between 50% to 90% more likely to develop knee osteoarthritis after anterior cruciate ligament reconstruction (ACL-R), it is unknown if ACL-R individuals exhibit knee adduction biomechanics related to OA development. This study sought to quantify speed and magnitude of knee adduction for knee OA and ACL-R individuals. We hypothesize that OA will exhibit larger, faster knee adduction biomechanics than ACL-R, which will increase at great walk speed and over a challenging surface. Six individuals with ACL-R and 8 individuals with knee OA had knee adduction quantified as they walked 1.3 m/s and at a self-selected speed over a flat and an uneven surface. Peak of stance, and average and maximum velocity of knee adduction joint angle and moment between heel strike and peak of stance were submitted to repeated measures ANOVA to compare main and interaction effects between group, speed and surface. There was a walk speed by group interaction for peak knee adduction moment (p = 0.048). Walk speed impacted maximum knee adduction joint angle (p=0.004) and moment velocity (p=0.041), while surface impacted peak knee adduction joint angle (p=0.035) and maximum knee adduction joint moment velocity (p=0.007). In partial agreement with our hypothesis, speed and magnitude knee adduction biomechanics increased with walk speed and surface, but OA did not consistently exhibit larger knee adduction biomechanics than ACL-R

Impact of Knee Injury and Disease on Frontal Plane Knee Biomechanics During Walk on Uneven Surfaces

Frontal plane knee biomechanics, in particular speed and magnitude of knee adduction motion, are implicated in knee osteoarthritis development. Although individuals are between 50% to 90% more likely to develop knee osteoarthritis after anterior cruciate ligament reconstruction (ACL-R), it is unknown if ACL-R individuals exhibit knee adduction biomechanics related to OA development. This study sought to quantify speed and magnitude of knee adduction for knee OA and ACL-R individuals. We hypothesize that OA will exhibit larger, faster knee adduction biomechanics than ACL-R, which will increase at great walk speed and over a challenging surface. Six individuals with ACL-R and 8 individuals with knee OA had knee adduction quantified as they walked 1.3 m/s and at a self-selected speed over a flat and an uneven surface. Peak of stance, and average and maximum velocity of knee adduction joint angle and moment between heel strike and peak of stance were submitted to repeated measures ANOVA to compare main and interaction effects between group, speed and surface. There was a walk speed by group interaction for peak knee adduction moment (p = 0.048). Walk speed impacted maximum knee adduction joint angle (p=0.004) and moment velocity (p=0.041), while surface impacted peak knee adduction joint angle (p=0.035) and maximum knee adduction joint moment velocity (p=0.007). In partial agreement with our hypothesis, speed and magnitude knee adduction biomechanics increased with walk speed and surface, but OA did not consistently exhibit larger knee adduction biomechanics than ACL-R

Surface, but Not Age, Impacts Lower Limb Joint Work during Walking and Stair Ascent

Older adults often suffer an accidental fall when navigating challenging surfaces during common locomotor tasks, such as walking and ascending stairs. This study examined the effect of slick and uneven surfaces on lower limb joint work in older and younger adults while walking and ascending stairs. Fifteen young (18–25 years) and 12 older (\u3e65 years) adults had stance phase positive limb and joint work quantified during walking and stair ascent tasks on a normal, slick, and uneven surface, which was then submitted to a two-way mixed model ANOVA for analysis. The stair ascent required greater limb, and hip, knee, and ankle work than walking (all p \u3c 0.001), with participants producing greater hip and knee work during both the walk and stair ascent (both p \u3c 0.001). Surface, but not age, impacted positive limb work. Participants increased limb (p \u3c 0.001), hip (p = 0.010), and knee (p \u3c 0.001) positive work when walking over the challenging surfaces, and increased hip (p = 0.015), knee (p \u3c 0.001), and ankle (p = 0.010) work when ascending stairs with challenging surfaces. Traversing a challenging surface during both walking and stair ascent tasks required greater work production from the large proximal hip and knee musculature, which may increase the likelihood of an accidental fall in older adults

Surface, but Not Age Impact Lower Limb Joint Work During Walk and Stair Ascent

During common locomotor activates, such as walk or stair negotiation, older adults exhibit unfavorable lower limb biomechanical changes, including diminished joint torque and power, and proximal mechanical work redistribution that may increase their fall risk. Twelve young (18 to 25 years) and 12 older (\u3e 65 years) adults performed a walk and stair ascent task on a normal, slick, and uneven surface. For each walk and stair ascent trial, synchronous 3D marker trajectories and GRF data were collected. Stance phase positive limb and joint work, and relative joint work were submitted to statistical analysis. Ascending stairs required more positive work than the walk, particularly from the knee, which may increase fall risk. Yet, both walking and ascending stairs over a challenging surface required more, proximally distributed work

Surface, but Not Age Impacts Lower Limb Joint Work During Stair Ascent

Introduction: Age-related loss in lower limb strength, particularly at the ankle, may impair older adults (over 65 years of age) mobility, and result in biomechanical deficits compared to their younger counterparts. Older adults tend to walk slower with shorter steps and exhibit diminished ankle joint kinetics (i.e., moment, power and work). Although the compromised ankle function leads older adults to produce smaller ankle joint torques and power output, reducing forces to propel the center of mass forward, it is unclear if they redistributed, or increase hip or knee work to safely walk, particularly when challenged with an uneven or slick surface. Objective: To compare positive lower limb work for young and older adults when walking over challenging surfaces, and determine whether redistributed power output. Methods: Twenty-eight (16 young, 18 to 25 years and 12 older, over 65 years) adults had positive work in the lower limb quantified when walking a self-selected speed over three surfaces (normal, uneven, and slick). Total limb, hip, knee and ankle positive work, and relative effort (% of total) at each joint were submitted to RM ANOVA to test main effect and interaction between surface (normal, uneven, and slick) and age (young and older adults). Results: Surface, but not age impact positive lower limb work. Surface impacted total limb (p=0.000), hip (p=0.007) and knee (p=0.001) positive work. The limb and knee produced more positive work on the uneven compared normal (

MOST Observations of the Flare Star AD Leo

We present continuous, high-precision photometric monitoring data with 1 minute cadence of the dM3e flare star AD Leo with the {\it MOST} satellite. We observed 19 flares in 5.8 days, and find a flare frequency distribution that is similar to previous studies. The light curve reveals a sinusoidal modulation with period of $2.23^{+0.36}_{-0.27}$ days that we attribute to the rotation of a stellar spot rotating into and out of view. We see no correlation between the occurrence of flares and rotational phase, indicating that there may be many spots distributed at different longitudes, or possibly that the modulation is caused by varying surface coverage of a large polar spot that is viewed nearly pole-on. The data show no correlation between flare energy and the time since the previous flare. We use these results to reject a simple model in which all magnetic energy is stored in one active region and released only during flares.Comment: 20 Pages, 8 Figures, PASP Accepte

Electrostatic Coupling between Two Surfaces of a Topological Insulator Nanodevice

We report on electronic transport measurements of dual-gated nano-devices of the low-carrier density topological insulator Bi1.5Sb0.5Te1.7Se1.3. In all devices the upper and lower surface states are independently tunable to the Dirac point by the top and bottom gate electrodes. In thin devices, electric fields are found to penetrate through the bulk, indicating finite capacitive coupling between the surface states. A charging model allows us to use the penetrating electric field as a measurement of the inter-surface capacitance $C_{TI}$ and the surface state energy-density relationship $\mu$(n), which is found to be consistent with independent ARPES measurements. At high magnetic fields, increased field penetration through the surface states is observed, strongly suggestive of the opening of a surface state band gap due to broken time-reversal symmetry.Comment: 5 pages, 4 figures, accepted to Physical Review Letter

Rapid West Nile Virus Antigen Detection

We compared the VecTest WNV antigen assay with standard methods of West Nile virus (WNV) detection in swabs from American Crows (Corvus brachyrhynchos) and House Sparrows (Passer domesticus). The VecTest detected WNV more frequently than the plaque assay and was comparable to a TaqMan reverse transcription–polymerase chain reaction

Visual pigments, ocular filters and the evolution of snake vision

Much of what is known about the molecular evolution of vertebrate vision comes from studies of mammals, birds and fish. Reptiles (especially snakes) have barely been sampled in previous studies despite their exceptional diversity of retinal photoreceptor complements. Here we analyse opsin gene sequences and ocular media transmission for up to 69 species to investigate snake visual evolution. Most snakes express three visual opsin genes (rh1, sws1, lws). These opsin genes (especially rh1 and sws1) have undergone much evolutionary change, including modifications of amino acid residues at sites of known importance for spectral tuning, with several tuning site combinations unknown elsewhere among vertebrates. These changes are particularly common among dipsadine and colubrine ‘higher’ snakes. All three opsin genes are inferred to be under purifying selection, though dN/dS varies with respect to some lineages, ecologies, and retinal anatomy. Positive selection was inferred at multiple sites in all three opsins, these being concentrated in transmembrane domains and thus likely to have a substantial effect on spectral tuning and other aspects of opsin function. Snake lenses vary substantially in their spectral transmission. Snakes active at night and some of those active by day have very transmissive lenses, while some primarily diurnal species cut out shorter wavelengths (including UVA). In terms of retinal anatomy, lens transmission, visual pigment spectral tuning and opsin gene evolution the visual system of snakes is exceptionally diverse compared to all other extant tetrapod orders

Hormesis results in trade-offs with immunity

Many have argued that we may be able to extend life and improve human health through hormesis, the beneficial effects of low-level toxins and other stressors. But, studies of hormesis in model systems have not yet established whether stress-induced benefits are cost free, artifacts of inbreeding, or come with deleterious side effects. Here, we provide evidence that hormesis results in trade-offs with immunity. We find that a single topical dose of dead spores of the entomopathogenic fungus, Metarhizium robertsii, increases the longevity of the fruit fly, Drosophila melanogaster, without significant decreases in fecundity. We find that hormetic benefits of pathogen challenge are greater in lines that lack key components of antifungal immunity (Dif and Turandot M). And, in outbred fly lines, we find that topical pathogen challenge enhances both survival and fecundity, but reduces ability to fight off live infections. The results provide evidence that hormesis is manifested by stress-induced trade-offs with immunity, not cost-free benefits or artifacts of inbreeding. Our findings illuminate mechanisms underlying pathogen-induced life-history trade-offs, and indicate that reduced immune function may be an ironic side effect of the “elixirs of life.