Beyond population engagement: understanding counterinsurgency

The US military has made considerable progress in developing counterinsurgency (COIN) strategy and doctrine, including the publication of Army Field Manual 3-24 and the military's successes in working with the population to stem the insurgency in Iraq. The short-term goals of COIN are now fairly well understood: engage the population and win their support. Whichever side wins the support of the population--either the host nation (and US forces that support it) or the insurgents--wins the battle. The battle is not the war, however. the long-term goal of a counterinsurgency campaign requires the creation of a functioning state, a government that can stand on its own, provide for its citizens, and promote regional and international stability; this achievement is victory in a counterinsurgency. Transitioning from the short-term success of population engagement to long-term viability of the host nation is far more difficult and less understood

A randomised controlled trial to compare immunogenicity between intramuscular and intradermal trivalent influenza vaccination in nursing home older adults

BACKGROUND: Immunosenescence in older adults contributes to unsatisfactory immunogenicity towards influenza vaccine. Intradermal (ID) administration of influenza vaccine has been suggested to improve immunogenicity but there is no study regarding the immunogenicity of ID influenza vaccination in nursing home older adults ...postprin

Local adverse effect of intradermal administration of influenza vaccination is an indicator of satisfactory immunogenicity

BACKGROUND: There are few studies concerning the association between immunogenicity of intradermal (ID) administration of influenza vaccination and adverse effect of vaccination ...postprin

Dose sparing intradermal trivalent influenza (2010/2011) vaccination overcome reduced immunogenicity of the 2009 H1N1 strain

This journal suppl. entitled: 18th Medical Research Conference; Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong KongOral PresentationBACKGROUND: We hypothesised that low-dose intradermal (ID) vaccination of the trivalent influenza vaccine (TIV) delivered by the MicronJet600TM (NanoPass Technologies, Israel) would be non-inferior to the full-dose intramuscular (IM) and mid-dose IntanzaR vaccination in ...postprin

Immunogenicity of intradermal trivalent influenza vaccine with topical imiquimod: a doubleblind randomised controlled trial

BACKGROUND: Imiquimod, a synthetic toll-like receptor 7-agonist enhanced immunogenicity of influenza vaccine in a mouse model. We hypothesised that topical imiquimod before intradermal trivalent influenza vaccination (TIV) will produce similar effect in human ...postprin

The Role of Imported Cases and Favorable Meteorological Conditions in the Onset of Dengue Epidemics

Dengue/dengue hemorrhagic fever is the world's most widely spread mosquito-borne arboviral disease and threatens more than two-thirds of the world's population. Cases are mainly distributed in tropical and subtropical areas in accordance with vector habitats for Aedes aegypti and Ae. albopictus. However, the role of imported cases and favorable meteorological conditions has not yet been quantitatively assessed. This study verified the correlation between the occurrence of indigenous dengue and imported cases in the context of weather variables (temperature, rainfall, relative humidity, etc.) for different time lags in southern Taiwan. Our findings imply that imported cases have a role in igniting indigenous outbreaks, in non-endemics areas, when favorable weather conditions are present. This relationship becomes insignificant in the late phase of local dengue epidemics. Therefore, early detection and case management of imported cases through timely surveillance and rapid laboratory-diagnosis may avert large scale epidemics of dengue/dengue hemorrhagic fever. An early-warning surveillance system integrating meteorological data will be an invaluable tool for successful prevention and control of dengue, particularly in non-endemic countries

Recruitment in the sea: bacterial genes required for inducing larval settlement in a polychaete worm

Metamorphically competent larvae of the marine tubeworm Hydroides elegans can be induced to metamorphose by biofilms of the bacterium Pseudoalteromonas luteoviolacea strain HI1. Mutational analysis was used to identify four genes that are necessary for metamorphic induction and encode functions that may be related to cell adhesion and bacterial secretion systems. No major differences in biofilm characteristics, such as biofilm cell density, thickness, biomass and EPS biomass, were seen between biofilms composed of P. luteoviolacea (HI1) and mutants lacking one of the four genes. The analysis indicates that factors other than those relating to physical characteristics of biofilms are critical to the inductive capacity of P. luteoviolacea (HI1), and that essential inductive molecular components are missing in the non-inductive deletion-mutant strains

Effects of NFKB1 and NFKBIA Gene Polymorphisms on Susceptibility to Environmental Factors and the Clinicopathologic Development of Oral Cancer

encoding IkappaBalpha (IκBα) with both the susceptibility to develop OSCC and the clinicopathological characteristics of the tumors.<.05), compared with those patients CC homozygotes. 519 might be a predictive factor for the distal metastasis of OSCC in Taiwanese