O OR RI IG GI IN NA AL L A AR RT TI IC CL LE E Effect of Green Manure and some Chemical Fertilizers on the Wheat Yield and some of its Components in Iran-North of Khuzestan

ABSTRACT In farm year of 2010-2011, a

Unerine fibrosis in young patients: clinical and pathogenetic

Detailed clinical and morphological study was undertaken on 101 young patients (age 20-30) diagnosed with Uterine fibrosis (the average patient age was 24,7±1,5 years). From the medical history, integrated clinical and morphological study, immunological analysis it was proved to exist two seldom forms of myomatous nodes at a young age: simplefibroid and invasive fibroid, that prevails. The growth originates in a vessel wall from the progenerating muscle cells with relatively high Ki-67 expression, high expression of growth factors and formation of new micro vessels (СD-34). These muscle cells have a very low apoptosis activity that determines the fast proliferation of cells (invasive fibroid)

SCIENTIFIC COOPERATION BETWEEN ARMENIAN AND THE EAEU: REALITY AND DEVELOPMENT TRENDS

The aim of this article is to analyze and assess the scientific collaboration between the Republic of Armenia (RA) and the Eurasian Economic Union (EAEU) member-states.In the Introduction, the article dwells into the integration processes that started right after the collapse of the Soviet Union with a main emphasis on the EAEU. The situation in the scientific sphere in Armenia is presented briefly, followed by highlighting the role of international scientific collaboration as a way to overcome a crisis in the science field.The role of the Committee of Sciences of the RA in the development of international collaboration is emphasized. The first steps in the framework of EAEU to activate scientific-technical cooperation are stressed.The Materials and Methods Section outlines the databases on which the study is based, that are the Web of Science Core Collection (WOS CC) and the Russian Science Citation Index (RSCI). The timeframe for the data retrieved from the WOS CC is 1991–2016, while for the RSCI — 2005–2016. The types of collaborations, as well as five stages of research — data retrieval from the WOS CC and the RSCI, data cleaning, quantitative analysis of citation, quantitative analysis of co-authored papers of the RA with each EAEU member-state and the distribution of the co-authored papers by the scientific fields — are mentioned.The Results Section presents the results of the study by the five mentioned stages and the relevant analysis.The Discussion and Conclusion Section presents the main conclusions of the study. It mainly stresses that Russia is the main scientific partner of Armenia, followed by Belarus. Scientific collaboration of Armenia with Kazakhstan and Kirgizia are on a very low level. Physics was recognized to be the leading field of collaboration. Generally, the article concludes that it is too early to speak about the role of the EAEU in the development of scientific collaboration between the member-states. In order to assure a stable growth of collaboration among the EAEU member-states a huge work should be done

Cleavage of Na+ channels by calpain increases persistent Na+ current and promotes spasticity after spinal cord injury

International audienceUpregulation of the persistent sodium current (INaP) in motoneurons contributes to spasticity following spinal cord injury (SCI). We investigated the mechanisms that regulate INaP and observed elevated expression of Nav1.6 channels in spinal lumbar motoneurons of adult rats with SCI. Furthermore, immunoblot revealed a proteolysis of Nav channels and biochemical assays identified calpain as the main proteolytic factor. Calpain-dependent cleavage of Nav channels following neonatal SCI was associated with an upregulation of INaP in motoneurons. Likewise, calpain-dependent cleavage of Nav1.6 channels expressed in HEK-293 cells caused elevation of INaP. Pharmacological inhibition of calpain by MDL28170 reduced the cleavage of Nav channels, INaP in motoneurons and spasticity in rats with SCI. Similarly, blockade of INaP by riluzole alleviated spasticity. This study demonstrates that Nav channel expression in lumbar motoneurons is altered after SCI and shows a tight relationship between the calpain-dependent proteolysis of Nav1.6 channels, the upregulation of INaP and spasticity

Cardiac phenotype in ATP1A3-related syndromes: A multicentre cohort study.

OBJECTIVE: To define the risks and consequences of cardiac abnormalities in ATP1A3-related syndromes. METHODS: Patients meeting clinical diagnostic criteria for Rapid-onset Dystonia-Parkinsonism (RDP), Alternating Hemiplegia of Childhood (AHC), and Cerebellar ataxia, Areflexia, Pes cavus, Optic atrophy, and Sensorineural hearing loss (CAPOS), with ATP1A3 genetic analysis, and had at least one cardiac assessment, were included. We evaluated the cardiac phenotype in an Atp1a3 knock-in mouse (Mashl+/-) to determine the sequence of events in seizure-related cardiac death. RESULTS: 98 AHC, nine RDP, and three CAPOS patients (63 females, mean age 17 years) were included. Resting EKG abnormalities were found in 52/87 (60%) AHC, 2/3 (67%) CAPOS, and 6/9 (67%) RDP patients. Serial EKGs showed dynamic changes in 10/18 AHC patients. The first Holter EKG was abnormal in 24/65 (37%) AHC and RDP cases, with either repolarization or conduction abnormalities. Echocardiography was normal. Cardiac intervention was required in 3/98 (∼3%) AHC patients. In the mouse model, resting EKGs showed intra-cardiac conduction delay; during induced seizures, heart block or complete sinus arrest led to death. CONCLUSIONS: We found increased prevalence of EKG dynamic abnormalities in all ATP1A3-related syndromes, with a risk of life-threatening cardiac rhythm abnormalities equivalent to that in established cardiac channelopathies (∼3%). Sudden cardiac death due to conduction abnormality emerged as a seizure-related outcome in murine Atp1a3-related disease. ATP1A3-related syndromes are cardiac diseases as well as neurological diseases. We provide guidance to identify patients potentially at higher risk of sudden cardiac death who may benefit from insertion of a pacemaker or implantable cardioverter-defibrillator