A Controlled Experiment to Evaluate Maintainability of Object-Oriented Software

New software tools and methodologies make claims that managers often believe intuitively without evidence. Many unsupported claims have been made about object-oriented programming. However, without scientific evidence, it is impossible to accept these claims as valid. Although experimentation has been done in the past, most of the research is very recent and the most relevant research has serious drawbacks. This paper describes an experiment which compares the maintainability of two functionally equivalent systems, in order to explore the claim that systems developed with object-oriented languages are more easily maintained than those programmed with procedural languages. We found supporting evidence that programmers produce more maintainable code with an object-oriented language than with a standard procedural language

Efficient Computation of Voronoi Diagrams

Voronoi diagrams have advantages of representing geometric information in a compact form which makes them well suited for robot path planning. However, researchers have often found them too complex and inefficient. In this paper, two alternate views of Voronoi diagrams, the Standard [SHAMM75a] and the generalized [KIRKD79] are reviewed. A new method to approximate the Voronoi diagram is developed while showing how all three can be effectively used in applications. Finally, the three methods are compared showing their relative strengths and weaknesses for robot path planning

Comparison of an Object-Oriented Programming Language to a Procedural Programming Language for Effectiveness in Program Maintenance

New software tools and methodologies make claims that managers often believe intuitively, without evidence. Many unsupported claims have been made about object-oriented programming. However, without scientific evidence, it is impossible to accept these claims as valid. Although experimentation has been done in the past, most of the research is very recent and the most relevant research has serious drawbacks. This paper describes an experiment which compares the maintainability of two functionally equivalent systems in order to explore the claim that systems developed with object-oriented languages are more easily maintained than those programmed with procedural languages. We found supporting evidence that programmers produce more maintainable code with an object oriented language than a standard procedural language

An evaluation framework for input variable selection algorithms for environmental data-driven models

Abstract not availableStefano Galelli, Greer B. Humphrey, Holger R. Maier, Andrea Castelletti, Graeme C. Dandy, Matthew S. Gibb

Evaluation of the Maintainability of Object-Oriented Software

Empirical research is one way of testing software engineering methodologies. Many claims of the advantages of the object oriented paradigm have been made by research. Our work involves empirical projects in an attempt to validate these claims. This paper describes an experiment which compares the maintainability of the two functionally equivalent systems in order to explore the claim that systems developed with object-oriented languages are more easily maintained than those programmed with procedural languages. We found supporting evidence that programmers produce more maintainable code with an object-oriented language than with a standard procedural language. Another on-going research effort attempts to measure the reusability of objects (written in C++) versus the reusability of procedures (written in Pascal). These experiments involve students, but unlike other published reports, deal with large systems

Signals for Lorentz Violation in Electrodynamics

An investigation is performed of the Lorentz-violating electrodynamics extracted from the renormalizable sector of the general Lorentz- and CPT-violating standard-model extension. Among the unconventional properties of radiation arising from Lorentz violation is birefringence of the vacuum. Limits on the dispersion of light produced by galactic and extragalactic objects provide bounds of 3 x 10^{-16} on certain coefficients for Lorentz violation in the photon sector. The comparative spectral polarimetry of light from cosmologically distant sources yields stringent constraints of 2 x 10^{-32}. All remaining coefficients in the photon sector are measurable in high-sensitivity tests involving cavity-stabilized oscillators. Experimental configurations in Earth- and space-based laboratories are considered that involve optical or microwave cavities and that could be implemented using existing technology.Comment: 23 pages REVTe

US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report

This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017.Comment: 102 pages + reference

The implications of three major new trials for the effect of water, sanitation and hygiene on childhood diarrhea and stunting: a consensus statement

BACKGROUND: Three large new trials of unprecedented scale and cost, which included novel factorial designs, have found no effect of basic water, sanitation and hygiene (WASH) interventions on childhood stunting, and only mixed effects on childhood diarrhea. Arriving at the inception of the United Nations' Sustainable Development Goals, and the bold new target of safely managed water, sanitation and hygiene for all by 2030, these results warrant the attention of researchers, policy-makers and practitioners. MAIN BODY: Here we report the conclusions of an expert meeting convened by the World Health Organization and the Bill and Melinda Gates Foundation to discuss these findings, and present five key consensus messages as a basis for wider discussion and debate in the WASH and nutrition sectors. We judge these trials to have high internal validity, constituting good evidence that these specific interventions had no effect on childhood linear growth, and mixed effects on childhood diarrhea. These results suggest that, in settings such as these, more comprehensive or ambitious WASH interventions may be needed to achieve a major impact on child health. CONCLUSION: These results are important because such basic interventions are often deployed in low-income rural settings with the expectation of improving child health, although this is rarely the sole justification. Our view is that these three new trials do not show that WASH in general cannot influence child linear growth, but they do demonstrate that these specific interventions had no influence in settings where stunting remains an important public health challenge. We support a call for transformative WASH, in so much as it encapsulates the guiding principle that - in any context - a comprehensive package of WASH interventions is needed that is tailored to address the local exposure landscape and enteric disease burden

DNA Vaccine-Generated Duck Polyclonal Antibodies as a Postexposure Prophylactic to Prevent Hantavirus Pulmonary Syndrome (HPS)

Andes virus (ANDV) is the predominant cause of hantavirus pulmonary syndrome (HPS) in South America and the only hantavirus known to be transmitted person-to-person. There are no vaccines, prophylactics, or therapeutics to prevent or treat this highly pathogenic disease (case-fatality 35–40%). Infection of Syrian hamsters with ANDV results in a disease that closely mimics human HPS in incubation time, symptoms of respiratory distress, and disease pathology. Here, we evaluated the feasibility of two postexposure prophylaxis strategies in the ANDV/hamster lethal disease model. First, we evaluated a natural product, human polyclonal antibody, obtained as fresh frozen plasma (FFP) from a HPS survivor. Second, we used DNA vaccine technology to manufacture a polyclonal immunoglobulin-based product that could be purified from the eggs of vaccinated ducks (Anas platyrhynchos). The natural “despeciation" of the duck IgY (i.e., Fc removed) results in an immunoglobulin predicted to be minimally reactogenic in humans. Administration of ≥5,000 neutralizing antibody units (NAU)/kg of FFP-protected hamsters from lethal disease when given up to 8 days after intranasal ANDV challenge. IgY/IgYΔFc antibodies purified from the eggs of DNA-vaccinated ducks effectively neutralized ANDV in vitro as measured by plaque reduction neutralization tests (PRNT). Administration of 12,000 NAU/kg of duck egg-derived IgY/IgYΔFc protected hamsters when administered up to 8 days after intranasal challenge and 5 days after intramuscular challenge. These experiments demonstrate that convalescent FFP shows promise as a postexposure HPS prophylactic. Moreover, these data demonstrate the feasibility of using DNA vaccine technology coupled with the duck/egg system to manufacture a product that could supplement or replace FFP. The DNA vaccine-duck/egg system can be scaled as needed and obviates the necessity of using limited blood products obtained from a small number of HPS survivors. This is the first report demonstrating the in vivo efficacy of any antiviral product produced using DNA vaccine-duck/egg system