3 research outputs found
A One-Pot Direct Iodination of the Fischer–Borsche Ring Using Molecular Iodine and Its Utility in the Synthesis of 6‑Oxygenated Carbazole Alkaloids
An
efficient regioselective iodination of the Fischer–Borsche
ring has been achieved using molecular iodine, in a one-pot synthesis.
The acid-, metal-, and oxidant-free conditions of the present method
are highly convenient and practical. Furthermore, the one-pot direct
iodination process is extended to the concise synthesis of glycozoline,
3-formyl-6-methoxy-carbazole, and 6-methoxy-carbazole-3-methylÂcarboxylate
natural alkaloids. This method has been proven to be tolerant to a
broad range of functional groups, with good to excellent yields
Copper (II) chloride: A regioselective catalyst for oxidative aromatization of pyrazoline, isoxazoline and 3-methyl flavanones
1091-1097A new protocol has
been reported in which a series of pyrazoline, isoxazoline and 3-methyl
flavanone has been conveniently aromatized by using CuCl2.2H2O
in DMSO within a short reaction time in excellent yields. The attraction of
this new protocol is regioselective aromatization of substrate 3i-j and <b style="mso-bidi-font-weight:
normal">5a-e which has been carried out to afford the aromatized product
with O-allyl group intact in excellent yield
Radical Beckmann Rearrangement and Its Application in the Formal Total Synthesis of Antimalarial Natural Product Isocryptolepine via C–H Activation
The
Beckmann rearrangement of ketoximes, mediated by ammonium persulfate-dimethyl
sulfoxide as a reagent, has been achieved under neutral conditions.
Based on the radical trapping and <sup>18</sup>O-labeling experiments,
the transformation follows a mechanism involving a radical pathway.
The scope and generality of the developed protocol has been demonstrated
by 19 examples. The developed protocol and Pd-catalyzed intramolecular
double C–H activation were used as key steps in the formal
total synthesis of antimalarial natural product isocryptolepine