A One-Pot Direct Iodination
of the Fischer–Borsche
Ring Using Molecular Iodine and Its Utility in the Synthesis of 6‑Oxygenated
Carbazole Alkaloids
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Abstract
An
efficient regioselective iodination of the Fischer–Borsche
ring has been achieved using molecular iodine, in a one-pot synthesis.
The acid-, metal-, and oxidant-free conditions of the present method
are highly convenient and practical. Furthermore, the one-pot direct
iodination process is extended to the concise synthesis of glycozoline,
3-formyl-6-methoxy-carbazole, and 6-methoxy-carbazole-3-methylcarboxylate
natural alkaloids. This method has been proven to be tolerant to a
broad range of functional groups, with good to excellent yields