Galactic-Scale Outflow and Supersonic Ram-Pressure Stripping in the Virgo Cluster Galaxy NGC 4388

The Hawaii Imaging Fabry-Perot Interferometer (HIFI) on the University of Hawaii 2.2m telescope was used to map the Halpha and [O III] 5007 A emission-line profiles across the entire disk of the edge-on Sb galaxy NGC 4388. We confirm a rich complex of highly ionized gas that extends ~4 kpc above the disk of this galaxy. Low-ionization gas associated with star formation is also present in the disk. Evidence for bar streaming is detected in the disk component and is discussed in a companion paper (Veilleux, Bland-Hawthorn, & Cecil 1999; hereafter VBC). Non-rotational blueshifted velocities of 50 - 250 km/s are measured in the extraplanar gas north-east of the nucleus. The brighter features in this complex tend to have more blueshifted velocities. A redshifted cloud is also detected 2 kpc south-west of the nucleus. The velocity field of the extraplanar gas of NGC 4388 appears to be unaffected by the inferred supersonic (Mach number M ~ 3) motion of this galaxy through the ICM of the Virgo cluster. We argue that this is because the galaxy and the high-|z| gas lie behind a Mach cone with opening angle ~ 80 degrees. The shocked ICM that flows near the galaxy has a velocity of ~ 500 km/s and exerts insufficient ram pressure on the extraplanar gas to perturb its kinematics. We consider several explanations of the velocity field of the extraplanar gas. Velocities, especially blueshifted velocities on the N side of the galaxy, are best explained as a bipolar outflow which is tilted by > 12 degrees from the normal to the disk. The observed offset between the extraplanar gas and the radio structure may be due to buoyancy or refractive bending by density gradients in the halo gas. Velocity substructure in the outflowing gas also suggests an interaction with ambient halo gas.Comment: 29 pages including 5 figures, Latex, requires aaspp4.sty, to appear in ApJ, 520 (July 20, 1999 issue

The Glucuronyltransferase GlcAT-P Is Required for Stretch Growth of Peripheral Nerves in Drosophila

During development, the growth of the animal body is accompanied by a concomitant elongation of the peripheral nerves, which requires the elongation of integrated nerve fibers and the axons projecting therein. Although this process is of fundamental importance to almost all organisms of the animal kingdom, very little is known about the mechanisms regulating this process. Here, we describe the identification and characterization of novel mutant alleles of GlcAT-P, the Drosophila ortholog of the mammalian glucuronyltransferase b3gat1. GlcAT-P mutants reveal shorter larval peripheral nerves and an elongated ventral nerve cord (VNC). We show that GlcAT-P is expressed in a subset of neurons in the central brain hemispheres, in some motoneurons of the ventral nerve cord as well as in central and peripheral nerve glia. We demonstrate that in GlcAT-P mutants the VNC is under tension of shorter peripheral nerves suggesting that the VNC elongates as a consequence of tension imparted by retarded peripheral nerve growth during larval development. We also provide evidence that for growth of peripheral nerve fibers GlcAT-P is critically required in hemocytes; however, glial cells are also important in this process. The glial specific repo gene acts as a modifier of GlcAT-P and loss or reduction of repo function in a GlcAT-P mutant background enhances VNC elongation. We propose a model in which hemocytes are required for aspects of glial cell biology which in turn affects the elongation of peripheral nerves during larval development. Our data also identifies GlcAT-P as a first candidate gene involved in growth of integrated peripheral nerves and therefore establishes Drosophila as an amenable in-vivo model system to study this process at the cellular and molecular level in more detail

New Physicians Setting Up a Rural Practice: It Isn't Easy

New physicians encounter more problems in setting up a rural practice than an urban one, according to a recent study of Georgia physicians. The problems for rural doctors range from inadequate hospital facilities to a sense of isolation from colleagues to unmet needs of other family members. Some of the problems can be mitigated by physician groups and community groups working together

Genome Sequence of the Brown Norway Rat Yields Insights Into Mammalian Evolution

The laboratory rat (Rattus norvegicus) is an indispensable tool in experimental medicine and drug development, having made inestimable contributions to human health. We report here the genome sequence of the Brown Norway (BN) rat strain. The sequence represents a high-quality 'draft' covering over 90% of the genome. The BN rat sequence is the third complete mammalian genome to be deciphered, and three-way comparisons with the human and mouse genomes resolve details of mammalian evolution. This first comprehensive analysis includes genes and proteins and their relation to human disease, repeated sequences, comparative genome-wide studies of mammalian orthologous chromosomal regions and rearrangement breakpoints, reconstruction of ancestral karyotypes and the events leading to existing species, rates of variation, and lineage-specific and lineage-independent evolutionary events such as expansion of gene families, orthology relations and protein evolution