42 research outputs found
Hypoglycemia mediated by paraneoplastic production of Insulin like growth factor–2 from a malignant renal solitary fibrous tumor – clinical case and literature review
Full text linkThe short-time structural plasticity of dendritic spines is altered in a model of Rett syndrome
Get PDFThe maturation of excitatory transmission comes about through a developmental period in which dendritic spines are highly motile and their number, form and size are rapidly changing. Surprisingly, although these processes are crucial for the formation of cortical circuitry, little is known about possible alterations of these processes in brain disease. By means of acute in vivo 2-photon imaging we show that the dynamic properties of dendritic spines of layer V cortical neurons are deeply affected in a mouse model of Rett syndrome (RTT) at a time around P25 when the neuronal phenotype of the disease is still mild. Then, we show that 24h after a subcutaneous injection of IGF-1 spine dynamics is restored. Our study demonstrates that spine dynamics in RTT mice is severely impaired early during development and suggest that treatments for RTT should be started very early in order to reestablish a normal period of spine plasticity
Insulin-Like Growth Factor-I in Kombination mit Insulin-Like Growth Factor Binding Protein-3 wirkt antiapoptotisch auf Hepatozyten
No full textCharacterization of insulin-like growth factor I receptors and growth effects in human lung cancer cell lines
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The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences
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Poly(ADP-Ribose)-Polymerase-Catalyzed Hydrolysis of NAD+: QM/MM Simulation of the Enzyme Reaction
No full textImmunohistochemical localization of insulin-like growth factor 1 and 2 in the endocrine pancreas of rat, dog, and man, and their coexistence with classical islet hormones
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